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IL-12 cytokine factory demonstrates success in targeting hard-to-treat cancers

A team of researchers from the Rice Biotech Launch Pad at Rice University has developed an implantable "cytokine factory" that safely triggers potent immune responses against hard-to-treat cancers, including metastatic melanoma, pancreatic and colorectal tumors.

8 Apr 2025

New drug compound prevents long COVID symptoms in mice

Researchers have shown a new drug compound can prevent long COVID symptoms in mice – a landmark finding that could lead to a future treatment for the debilitating condition.

8 Apr 2025

Single dose of osanetant reduces fear response in female mice after trauma

A new Brevia (peer-reviewed research report) published in Brain Medicine reveals that a single dose of the drug Osanetant, administered shortly after a traumatic event, significantly dampens fear expression in female mice.

8 Apr 2025

New drug shows neuroprotective and anti-inflammatory effects in murine models of Alzheimer's

Alzheimer's disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease.

2 Apr 2025

Assessing the impact of the particle drift effect on oral drug absorption using flux tools

Discover how particle drift analysis using flux tools improves oral drug absorption in pharmaceutical research.

From Pion Inc 31 Mar 2025

Study uncovers how resistance to chemotherapies may occur in some cancers

Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells.

28 Mar 2025

Study finds 24-hour fasting cycles enhance libido in male mice

Long-term fasting in 24-hour cycles increases the sex drive of male mice by lowering the concentration of the neurotransmitter serotonin in the brain.

28 Mar 2025

New peptide antibiotic stops bacteria by binding where no drug has before

Researchers discovered lariocidin, a lasso peptide antibiotic that kills multidrug-resistant bacteria by binding a novel ribosomal site.

27 Mar 2025

Microneedles accelerate diabetic wound healing in preclinical models

Diabetic wounds often lead to severe complications that can result in amputations. These chronic and non-healing wounds are marked by persistent inflammation, affecting more than six per cent of the global population.

26 Mar 2025

Scientists uncover role of m6A in prostate cancer progression

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center and the University of Toronto have revealed how a tiny chemical modification in RNA, known as m6A, plays a critical role in the progression of prostate cancer, including driving some of its most dangerous forms of the disease.

24 Mar 2025

Novel long-acting contraceptive implant can be delivered through tiny needles

Mass General Brigham and MIT investigators have developed a long-acting contraceptive implant that can be delivered through tiny needles to minimize patient discomfort and increase the likelihood of medication use.

24 Mar 2025

New MIT method promises less painful drug injections with tiny crystals

MIT engineers have devised a new way to deliver certain drugs in higher doses with less pain, by injecting them as a suspension of tiny crystals.

24 Mar 2025

Nanotechnology innovation aims to improve breast cancer treatment

University of Queensland researchers are designing nanotechnology they believe could improve how we treat the most aggressive form of breast cancer.

24 Mar 2025

A versatile toolbox sets gold standard for characterizing IRES activity in cells

Only recently has the ribosome - one of the oldest molecular machines in evolutionary terms - been recognized as an active regulator of gene expression at the level of protein biosynthesis.

20 Mar 2025

Researchers discover neutrophils that strengthen skin barrier

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Dr. Andrés Hidalgo has discovered a specialized population of neutrophils in the skin that produce extracellular matrix, helping to maintain the skin's resistance and integrity.

19 Mar 2025

AI-based neural network revolutionizes cancer treatment predictions

A first-of-its-kind artificial intelligence (AI)-based neural network can rapidly analyze and interpret millions of cells from a patient sample, predicting molecular changes in the tissue.

18 Mar 2025

Autonomic dysfunction linked to impaired gastric activity in stroke patients

Gastrointestinal complications are common in patients after ischemic stroke. Gastric motility is regulated by gastric pace-making activity (also called gastric myoelectrical activity (GMA)) and autonomic function.

18 Mar 2025

New AI tool revolutionizes sleep analysis with comprehensive sleep data

Researchers at the Icahn School of Medicine have developed a powerful AI tool, built on the same transformer architecture used by large language models like ChatGPT, to process an entire night's sleep.

17 Mar 2025

Impact of excessive alcohol consumption on digestive health

Excessive alcohol consumption is a significant public health concern, responsible for approximately 6% of all deaths and contributing to 5.1% of the global disease burden.

12 Mar 2025

Four new institutions join BD² Integrated Network to improve bipolar disorder care

Today, Breakthrough Discoveries for thriving with Bipolar Disorder (BD²) announced four new national institutions to receive $2.3 million each to join the BD² Integrated Network, a collaborative research and clinical care model that will improve care, interventions, and outcomes for people living with bipolar disorder.

12 Mar 2025