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Role of uric acid in heart disease

In this month's premier open access medical journal PLoS Medicine, John Danesh and colleagues from the University of Cambridge, along with investigators from the Icelandic Heart Association, report the single largest prospective study addressing the role of uric acid in heart disease.

29 Mar 2005

Pcsk9 gene - new target for cholesterol-lowering drugs

Mice lacking a key protein involved in cholesterol regulation have low-density lipoprotein, or "bad" cholesterol, levels more than 50 percent lower than normal mice, and researchers suggest that inhibiting the same protein in humans could lead to new cholesterol-lowering drugs.

29 Mar 2005

Left-right brain mystery - trail is hot and cold

Australian National University (ANU) researchers have developed a new device that could potentially unravel the mysteries of the left and right brain by measuring ear temperature.

29 Mar 2005

New prostate cancer test

Tessera, Inc., a Seattle-based biomedical company, has released its first product, ProstaMark EPCA (Early Prostate Cancer Antigen), as an Analyte Specific Reagent (ASR) for commercial use in pathology laboratories to assist pathologists in their efforts to determine if cancer is present in the prostate.

28 Mar 2005

Discovery of gene STAT6(B) may lead to new treatments for inflammatory diseases

In a paper featured in Proceedings of the National Academy of Science (PNAS), researchers from Boston University School of Dental Medicine report the discovery of a new gene, STAT6(B), that helps regulate production of the potentially deadly tumor necrosis factor alpha (TNF-alpha) cytokine.

28 Mar 2005

KCP protein protects kidneys from damage caused by chronic renal disease and injury

University of Michigan scientists have identified a new and unusual protein that reduces, in laboratory mice, kidney damage caused by chronic renal disease and acute toxic injuries.

28 Mar 2005

Body fat may promote inflammation

Why does extra fat around the waist increase the risk of heart disease? A new study by Wake Forest University Baptist Medical Center researchers and colleagues suggests that inflammation may be the key.

28 Mar 2005

Social and cultural factors play a significant role in the treatment decisions of patients with prostate cancer

Marital status, high school education, and race/ethnicity may play a far greater role in patients' treatment decisions than previously believed.

28 Mar 2005

Variation in the gene ENPP1 may predict risk for diabetes

A particular gene variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwestern Medical Center.

28 Mar 2005

New color-coded test for protein folding

Every protein--from albumin to testosterone--is folded into a unique, three-dimensional shape that allows it to function properly. Now Stanford University scientists have developed a simple test that instantly changes color when a protein molecule attached to a gold nanoparticle folds or unfolds.

28 Mar 2005

Gene/yeast finding links processes in heart disease and cancer

By studying a little-known yeast too primitive to get diseases, Johns Hopkins researchers have uncovered a surprising link between two processes at play in heart disease and cancer in people.

28 Mar 2005

Molecule that causes secondary stroke

Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm.

28 Mar 2005

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

Identifying the genetic malfunction that causes these disorders raises the hope that researchers may be able to devise a targeted therapy, just as they have done for chronic myelogenous leukemia (CML), which is presently treated with Gleevec. The three leukemias that share a common genetic cause are polycythemia vera (PV), essential thrombocythemia (ET) and myeloid metaplasia with myelofibrosis (MMM).

28 Mar 2005

New therapy for treating cat allergies looks promising

Andrew Saxon, M.D., and a team of researchers at University of California, Los Angeles (UCLA) have found that a molecule designed to block cat allergies can prevent allergic reactions in laboratory mice and was also successful when tested on human cells in a test tube.

28 Mar 2005

Primary care office strategies may increase colon cancer screening

Patients are more likely to receive colorectal cancer screening when primary care practices use an office systems approach, according to an article in the March 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

28 Mar 2005

Acupuncture treatments using low levels of electrical stimulation can lower blood pressure

Acupuncture treatments using low levels of electrical stimulation can lower elevations in blood pressure by as much as 50 percent, researchers at the Susan Samueli Center for Integrative Medicine at UC Irvine have found.

28 Mar 2005

Most accurate estimates of the causes of child deaths to date

The most accurate estimates of the causes of child deaths to date, published in this week’s issue of The Lancet, reveal that worldwide more than 70% of the 10·6 million child deaths that occur annually are attributable to six causes: pneumonia (19%), diarrhoea (18%), malaria (8%), neonatal sepsis or pneumonia (10%), preterm delivery (10%), and asphyxia at birth (8%).

28 Mar 2005

Bacteria found in the mouth may predict pregnancy outcomes

Researchers from New York University found that certain bacteria from the mouth may be related to preterm delivery and low birthweight according to a study in the Journal of Periodontology (JOP).

23 Mar 2005

Evidence of cross-activation in brain regions of people who see letters and numbers in colors

Synesthesia, a condition characterized by one sensory experience generating another – so that shapes have tastes, for instance – is estimated to affect between 1 in 200 to 1 in 2,000 people. The most common form involves seeing specific letters or numbers (graphemes) in specific colors.

23 Mar 2005

First patient to test new treatment for peripheral arterial disease

For several years, crippling leg pain has prevented Joan Erickson from walking more than a block. If she paused to rest, she could walk a little more, but not enough to continue playing golf, her favorite pastime.

23 Mar 2005

Blood News and Research

Role of uric acid in heart disease

Pcsk9 gene - new target for cholesterol-lowering drugs

Left-right brain mystery - trail is hot and cold

New prostate cancer test

Discovery of gene STAT6(B) may lead to new treatments for inflammatory diseases

KCP protein protects kidneys from damage caused by chronic renal disease and injury

Body fat may promote inflammation

Social and cultural factors play a significant role in the treatment decisions of patients with prostate cancer

Variation in the gene ENPP1 may predict risk for diabetes

New color-coded test for protein folding

Gene/yeast finding links processes in heart disease and cancer

Molecule that causes secondary stroke

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

New therapy for treating cat allergies looks promising

Primary care office strategies may increase colon cancer screening

Acupuncture treatments using low levels of electrical stimulation can lower blood pressure

Most accurate estimates of the causes of child deaths to date

Bacteria found in the mouth may predict pregnancy outcomes

Evidence of cross-activation in brain regions of people who see letters and numbers in colors

First patient to test new treatment for peripheral arterial disease

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