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New study lays foundation for future gene replacement therapies to treat ALS patients

Scientists have demonstrated for the first time that it is possible to specifically modify gene expression in diseased upper motor neurons, brain cells that break down in ALS.

1 Feb 2016

Rochester scientists identify stem cells capable of skull formation, craniofacial bone repair in mice

A team of Rochester scientists has, for the first time, identified and isolated a stem cell population capable of skull formation and craniofacial bone repair in mice--achieving an important step toward using stem cells for bone reconstruction of the face and head in the future, according to a new paper in Nature Communications.

1 Feb 2016

MGH study may lead to first nonsurgical treatment for seborrheic keratoses

An investigation into the molecular mechanisms responsible for the most common type of benign skin lesion may lead to the first nonsurgical treatment for the growths called seborrheic keratoses (SKs), which in addition to being cosmetically unattractive are often worrisome to patients.

30 Jan 2016

TSRI scientists reveal workings of key 'relief-valve' in cells

A team led by scientists at The Scripps Research Institute has solved a long-standing mystery in cell biology by showing essentially how a key "relief-valve" in cells does its job.

30 Jan 2016

Researchers discover previously unknown mechanism that regulates neurogenesis

Bassem Hassan's team at VIB/KU Leuven has discovered a previously unknown mechanism that is highly conserved between species and which regulates neurogenesis through precise temporal control of the activity of a family of proteins essential for brain development: the proneural proteins.

30 Jan 2016

New patient-friendly website launched for people diagnosed with KRAS-mutant lung cancer

LUNGevity President Andrea Ferris, a member of the Stand Up to Cancer Lung Cancer Dream Team, presented the team's newly launched website, a patient-centric resource that enables users to be active, informed participants in their diagnosis and treatment, at a poster session at the 2016 Stand Up to Cancer (SU2C) Scientific Summit.

30 Jan 2016

Multinational study suggests new way to classify gliomas

A comprehensive analysis of the molecular characteristics of gliomas—the most common malignant brain tumor—explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.

29 Jan 2016

Access for new melanoma treatment remains uncertain for patients despite UK launch

Novartis announced today that Tafinlar (dabrafenib) + Mekinist (trametinib), the first oral combination therapy to be licensed for advanced melanoma, is now available in the UK for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.

29 Jan 2016

New treatment could stop progression of ALS

Researchers at Oregon State University announced today that they have essentially stopped the progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, for nearly two years in one type of mouse model used to study the disease - allowing the mice to approach their normal lifespan.

29 Jan 2016

New NYUCD study explores how gene expression initiated in notochord

A new study by basic science researchers in the Department of Basic Science and Craniofacial Biology at New York University College of Dentistry sought to understand how gene expression is initiated in the notochord, the evolutionary and developmental precursor of the backbone.

29 Jan 2016

Genetic mutations could help explain cause of cancer in pediatric patients

Combined whole exome tumor and blood sequencing in pediatric cancer patients revealed mutations that could help explain the cause of cancer or have the potential to impact clinical cancer care in 40 percent of patients in a study led by researchers from Baylor College of Medicine and Texas Children's Cancer Center.

29 Jan 2016

VARI-SU2C Epigenetics Dream Team supports new clinical trial that targets metastatic colorectal cancer

The first clinical trial to move forward as part of the Van Andel Research Institute-Stand Up To Cancer (VARI-SU2C) Epigenetics Dream Team will target metastatic colorectal cancer, the second leading cause of cancer deaths among men and women combined in the U.S.

29 Jan 2016

Mutation or amplification of HER2 gene may lead to lung cancer

A joint study by University of Colorado Cancer Center and Memorial Sloan Kettering Cancer Center published in the Journal of Thoracic Oncology shows two distinct causes of HER2 activation in lung cancer: mutation of the gene and amplification of the gene.

29 Jan 2016

HIV persists in the body despite effective antiretroviral therapy

A team of international scientists led by Northwestern University found that HIV is still replicating in lymphoid tissue, even when it is undetectable in the blood of patients on antiretroviral drugs.

28 Jan 2016

CUMC, Iowa scientists use CRISPR to repair genetic mutation responsible for retinitis pigmentosa

Columbia University Medical Center and University of Iowa scientists have used a new gene-editing technology called CRISPR, to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at least 1.5 million cases worldwide.

28 Jan 2016

Stopping disruptions in cellular 'trash removal' may guard against neurodegenerative diseases

Stopping disruptions in cellular "trash removal" brought on by errors in molecular marks on DNA may guard against neurodegenerative diseases like Parkinson's.

27 Jan 2016

DNA imprinting defect may affect children diagnosed with osteosarcoma

Children diagnosed with osteosarcoma may be impacted by a DNA imprinting defect also found in parents, according to new research from the Masonic Cancer Center, University of Minnesota. DNA imprinting is a phenomenon in which just one of the two inherited genes is active while the other is present but inactive.

27 Jan 2016

FDA expands use of Opdivo + Yervoy Regimen for BRAF V600 mutant and wild-type advanced melanoma

Bristol-Myers Squibb Company today announced that the U.S. Food and Drug Administration has approved Opdivo in combination with Yervoy for the treatment of patients with BRAF V600 wild-type and BRAF V600 mutation-positive unresectable or metastatic melanoma.

27 Jan 2016

Quest Diagnostics to offer in vitro diagnostic test for use in detection of PD-L1 expression for melanoma

Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced it will offer clinical laboratory testing using the PD-L1 IHC 28-8 pharmDx qualitative test from Dako, an Agilent Technologies company.

From Quest Diagnostics 27 Jan 2016

Carbapenem-resistant Enterobacteriaceae: an interview with Dr. Michael Dudley

Enterobacteriaceae refer to the family of bacteria such as E. coli and Klebsiella that are bacterial pathogens most frequently associated with hospital-acquired infections

25 Jan 2016

Mutation News and Research

New study lays foundation for future gene replacement therapies to treat ALS patients

Rochester scientists identify stem cells capable of skull formation, craniofacial bone repair in mice

MGH study may lead to first nonsurgical treatment for seborrheic keratoses

TSRI scientists reveal workings of key 'relief-valve' in cells

Researchers discover previously unknown mechanism that regulates neurogenesis

New patient-friendly website launched for people diagnosed with KRAS-mutant lung cancer

Multinational study suggests new way to classify gliomas

Access for new melanoma treatment remains uncertain for patients despite UK launch

New treatment could stop progression of ALS

New NYUCD study explores how gene expression initiated in notochord

Genetic mutations could help explain cause of cancer in pediatric patients

VARI-SU2C Epigenetics Dream Team supports new clinical trial that targets metastatic colorectal cancer

Mutation or amplification of HER2 gene may lead to lung cancer

HIV persists in the body despite effective antiretroviral therapy

CUMC, Iowa scientists use CRISPR to repair genetic mutation responsible for retinitis pigmentosa

Stopping disruptions in cellular 'trash removal' may guard against neurodegenerative diseases

DNA imprinting defect may affect children diagnosed with osteosarcoma

FDA expands use of Opdivo + Yervoy Regimen for BRAF V600 mutant and wild-type advanced melanoma

Quest Diagnostics to offer in vitro diagnostic test for use in detection of PD-L1 expression for melanoma

Carbapenem-resistant Enterobacteriaceae: an interview with Dr. Michael Dudley

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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