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Researchers focus on uncoupling obesity from diabetes

About 422 million people around the world, including more than 30 million Americans, have diabetes. Approximately ninety percent of them have type 2 diabetes. People with this condition cannot effectively use insulin, a hormone made by the pancreas that helps the body turn blood sugar into energy.

15 Aug 2018

New strategy accelerates, automates process of prototype molecule optimization

The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology.

14 Aug 2018

Neural stem cells are the key to tail regeneration

Cut off a salamander's tail and, in a few weeks, a near-perfect replacement grows. Do the same to a lizard and a new tail will regrow, but it won't be the same as the original. By comparing tail regeneration between the two animals, researchers at the University of Pittsburgh School of Medicine found that stem cells in the spinal cord are the ultimate limiting factor.

14 Aug 2018

Scientists discover biomarker for kidney cancer

Scientists have discovered a new blood biomarker that could help predict the risk of kidney cancer.

13 Aug 2018

New marker in the blood could help predict person's risk of developing kidney cancer

Scientists have discovered that a marker in the blood could help predict the risk that a person will develop kidney cancer, according to research published in the journal Clinical Cancer Research.

13 Aug 2018

Novel blood-based marker may help predict kidney cancer years before clinical diagnosis

A critical biomarker of kidney disease may help predict clear cell kidney cancer - the most common form of kidney cancer - years before clinical diagnosis. Kidney-injury-molecule-1 can be detected in the urine and blood and is generally present at low levels in healthy individuals.

10 Aug 2018

Scientists uncover mechanisms responsible for development of fibrosis

Idiopathic pulmonary fibrosis is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process.

10 Aug 2018

Researchers uncover new details in how the olfactory epithelium develops

Dogs, known for their extraordinarily keen senses of smell, can be trained to use their sensitive sniffers to find drugs, bombs, bed bugs, missing hikers and even cancer. Among dogs and other animals that rely on smell, at least one factor that may give them an advantage is a sheet of tissue in the nasal cavity.

10 Aug 2018

PARP inhibitors show promise for treating and preventing brain disorders

A class of cancer drugs called PARP inhibitors could be useful for treating and preventing brain disorders, including amyotrophic lateral sclerosis, also called Lou Gehrig's disease, and some forms of frontotemporal degeneration, by halting the misplacement of specific proteins that affect nerve cells, according to a study published in Molecular Cell by researchers in the the School of Arts and Sciences and the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2018

New laboratory-synthesized molecule appears to fight malaria effectively

A novel laboratory-synthesized molecule based in natural compounds found in marine gliding bacteria - known as marinoquinolines - is a strong candidate for the development of a new antimalarial drug.

10 Aug 2018

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

HIV-1 replicates in ninja-like ways. The virus slips through the membrane of vital white blood cells. Inside, HIV-1 copies its genes and scavenges parts to build a protective bubble for its copies.

10 Aug 2018

Biomarkers responsible for exhaustion in cancer linked to fatigue in Parkinson's disease

Biological markers responsible for extreme exhaustion in patients with cancer have now been linked to fatigue in those with Parkinson's disease, according to new research from Rice University.

10 Aug 2018

Study: Rare lymphoid cells play key role in development of inflammatory arthritis

Immunologists at Friedrich-Alexander-Universität Erlangen-Nürnberg have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis.

10 Aug 2018

Collaboration between Merck and InnoCore could improve biologic drug delivery

Following today’s (Friday 3 August) announcement of Merck and InnoCore’s collaboration, Rahael Maladwala, Pharma Analyst at GlobalData, a leading data and analytics company, offers his view on what this might mean for biologic drug delivery:

10 Aug 2018

Researchers discover genetic mutation underlying debilitating childhood brain disorder

Ashleigh Schaffer, PhD, assistant professor of genetics at Case Western Reserve University School of Medicine, and a team of global genetics experts have discovered a genetic mutation and the faulty development process it triggers, causing a debilitating brain-based disorder in children.

9 Aug 2018

Researchers describe new class of potent inhibitors against amyloid plaques

Effective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available.

9 Aug 2018

Scientists identify key neurobiological mechanisms that control aggression

A number of psychiatric disorders present with aggression and violence, which, needless to say, are destructive to both individuals and societies worldwide: death, disease, disability, and numerous socioeconomic problems can often be traced back to aggressive behavior.

9 Aug 2018