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State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions and is damaged through neurodegenerative diseases or conditions like sepsis.

7 Oct 2025

Innovative approaches target PAR2 receptor to alleviate gut pain

Abdominal pain is a hallmark of many digestive disorders, including inflammatory bowel disease and irritable bowel syndrome.

7 Oct 2025

Unraveling the brain mechanisms behind social hierarchies in mice

Social hierarchies are everywhere-think of high school dramas, where the athletes are portrayed as most popular, or large companies, where the CEO makes the important decisions.

7 Oct 2025

New experimental methods show selective attention effect is exclusively cortical in humans

Research led by the University of Michigan's Kresge Hearing Research Institute and the University of Rochester illuminates the mechanisms through which humans can pick out and focus on single sounds in noisy environments.

6 Oct 2025

Nanotechnology breakthrough reverses Alzheimer’s disease in mice

A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer's disease in mice.

6 Oct 2025

Live retinal imaging uncovers early signs of diabetic eye disease

A new method of taking microscopic images of a live mouse's retina through the eye allows to record the reaction of brain cells to disease and treatment.

6 Oct 2025

Investigating cannabidiol's role in combating Alzheimer's-related neuroinflammation

Neuroinflammation damages neurons and can contribute to diseases like Alzheimer's. Cannabidiol (CBD) has anti-inflammatory properties, which suggests that it could combat neuroinflammation in Alzheimer's.

6 Oct 2025

Researchers identify a central controller of mitochondrial dynamics in disease

A key switch for cellular energy balance has been discovered in cells: it could potentially become the target of new therapies for diseases ranging from Parkinson's to rare disorders caused by defects in the cell's powerhouses, the mitochondria.

6 Oct 2025

New ultrasound technique used to stimulate multiple locations in the brain simultaneously

For the first time, a new ultrasound technique allows researchers to stimulate multiple locations in the brain simultaneously.

3 Oct 2025

Study suggests spatial memory decline may be preventable and not universal

In the realm of memories, "where" holds special importance. Where did I leave my keys? Where did I eat dinner last night? Where did I first meet that friend? Recalling locations is necessary for daily life, yet spatial memory - which keeps track of "where" - is one of the first cognitive abilities to fade in old age. And deficits earlier in life can be a telltale sign of dementia.

3 Oct 2025

Study links high neuroinflammation in young people with Down Syndrome to Alzheimer's risk

Down syndrome is associated with accelerated aging. It is estimated that up to 90% of individuals with the condition develop Alzheimer's disease before the age of 70. A study by researchers at the University of São Paulo (USP) in Brazil identified high levels of neuroinflammation in young individuals with Down syndrome, an additional factor explaining the high prevalence of Alzheimer's disease in older people with the condition. The discovery paves the way for strategies to prevent and monitor the disease.

3 Oct 2025

New tool enables and enhances protein investigations

A new tool greatly improves scientists' ability to identify and study proteins that regulate gene activity in cells, according to research led by Weill Cornell Medicine investigators. The technology should enable and enhance investigations in both fundamental biology and disease research.

3 Oct 2025

Study uncovers cerebellar involvement and social impairment

Spinal muscular atrophy is a rare genetic disease of the nerve cells in the spinal cord that can appear as early as infancy. The disease leads to a progressive loss of muscle strength. Those affected often suffer from muscle weakness early on, as well as difficulties with movement, breathing, and swallowing.

3 Oct 2025

Penn Medicine study maps brain circuits impacted by psilocybin

Researchers at Penn Medicine have identified specific brain circuits that are impacted by psilocybin-the active compound found in some psychedelic mushrooms-which could lead to new paths forward for pain and mental health management options.

2 Oct 2025

Targeting the cerebellum to ease alcohol withdrawal symptoms

By targeting a specific area of the brain, researchers at Washington State University may now hold the key to curbing the debilitating symptoms of alcohol withdrawal that push many people back to drinking.

30 Sep 2025

Telestroke expands care access but prolongs critical treatment time

Stroke patients evaluated using telemedicine (telestroke) have higher odds of receiving essential treatment, yet it takes them significantly longer to be treated - potentially limiting the benefits, a Michigan Medicine-led study finds.

26 Sep 2025

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson's disease. The disease presents a complex set of motor symptoms, including tremors, rigidity, bradykinesia, and postural instability.

26 Sep 2025

Scientists explore how dopamine shapes myelin in social isolation

Scientists know that social isolation can alter brain structure and lead to the breakdown of myelin, the fatty coating that insulates nerve fibers in the brain. But they don't yet know exactly how or why it happens.

25 Sep 2025

Calcium-induced release identified as key driver of dangerous muscle disorders

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

25 Sep 2025

Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis

A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer's disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.

25 Sep 2025