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New findings may help widen therapeutic interventions for B-cell acute lymphoblastic leukemia

A retrospective study led by Northwestern Medicine investigators found that the chimeric antigen receptor (CAR) T-cell immunotherapy drug tisagenlecleucel demonstrated safety and efficacy in pediatric patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-cell ALL), even when the drug doesn't meet the FDA's strict manufacturing standards.

19 Oct 2021

Lactoferrin supplements could be used as adjunct for COVID-19 and other respiratory tract infections

The antiviral properties of lactoferrin makes it a great natural supplement that could also be used as an adjunct for COVID-19 and for various other Respiratory Tract Infections (RTIs) according to a team of researchers led by the University of Huddersfield.

19 Oct 2021

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

A new preprint suggests a fruitful approach to develop such drugs based on biochemical and molecular modeling studies of the drug remdesivir.

19 Oct 2021

COVID-19 vaccine breakthrough infections among immunocompromised individuals

A study of breakthrough infections in immunocompromised people following two doses of the Pfizer/BioNTech vaccine against SARS-CoV-2 concluded that immunocompromised people would be best served with a third dose of the vaccine for better protection.

19 Oct 2021

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Researchers performed a large-scale, double-blind, placebo-controlled phase two trial to assess the efficacy, safety, and immune response elicited from vaccination with MVC-COV1901.

19 Oct 2021

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

Waning COVID vaccine efficacy especially against reinfection

A new study in American veterans posted to the medRxiv* preprint server suggests severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are less effective in preventing infection after six months. The decline was most significant with the Johnson & Johnson vaccine, with vaccine effectiveness plummeting from 88% to 3%.

19 Oct 2021

Study: Funny memes may help people cope with COVID-19 stress

Funny memes may help people cope with the stress of the COVID-19 pandemic, making viewers feel calmer and more content, according to research published by the American Psychological Association.

18 Oct 2021

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

A new study discusses risk factors for the failure of seroconversion following full vaccination with the COVID-19 Pfizer vaccine.

18 Oct 2021

High levels of cancer-fighting immune cells could indicate a better chance of survival

Cancerous tumors are made up of many more components than just malignant cells from the tissue of origin. Immune cells can be recruited to the tumor site and form what is known as the tumor microenvironment.

18 Oct 2021

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia.

18 Oct 2021

Novel combination therapy identified for the brain metastases of breast cancer

A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy.

18 Oct 2021

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

Researchers from Singapore conducted a study to assess the spike protein-specific humoral and cellular immunity in Ad26.COV2.S vaccinated individuals either primed with Ad26.COV2.S only, or boosted with a homologous or heterologous second dose.

18 Oct 2021

What will it take to boost vaccinations? The scene from Kentucky’s back roads

In the end it was the delta variant that drove Rose Mitchell, 89, down the winding mountain road to the Full Gospel Church of Jesus Christ to get the shot. Her pastor, Billy Joe Lewis, had told his congregation that, No, ma'am, a covid vaccine would not leave the "mark of the beast" nor rewrite their genetic codes.

18 Oct 2021

Use of wearable and wireless inertial sensor systems for treating movement disorders

In their new book, Applied Software Development with Python & Machine Learning by Wearable & Wireless Systems for Movement Disorder Treatment via Deep Brain Stimulation, Dr. Robert LeMoyne and Timothy Mastroianni present the confluence of wearable and wireless inertial sensor systems, such as a smartphone, and machine learning, for deep brain stimulation for treating movement disorders, such as essential tremor.

18 Oct 2021

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

To address the gaps in the knowledge, a team of researchers from the University of California and the Gladstone Institute of Virology conducted 39-parameter phenotyping by cytometry by time of flight (CyTOF) on 33 longitudinal specimens from 11 mRNA-vaccinated individuals, of which six had previously been infected and recovered from COVID-19.

18 Oct 2021

New class of CXCR4 antagonists could prevent airway inflammation and atopic dermatitis

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been identified as endogenous peptide antagonist andinverse agonistof CXCR4 and is a promising compound for the development of improved analogues for the therapy of CXCR4-associated diseases.

18 Oct 2021

Engineered 3D scaffolds of human brown adipose tissue as a new therapeutic strategy for obesity and diabetes

A group of researchers from various institutes in the USA addressed the limitations of BAT therapy by transplanting a low dose of brown adipocytes (BAs) without Matrigel to determine if this could alleviate high-fat diet-induced OB, metabolic symptoms, and T2DM in mice.

18 Oct 2021

Pandemic-related grief associated with lower levels of mother-infant bonding

The emotional connection between a mother and her newborn baby can lay the foundation for the child's development and the family's outcomes.

15 Oct 2021

Zinc oxide in sunscreens destroys UVA protection during sun exposure

During use some sunscreens offer very limited protection against dangerous sunrays and may even be harmful.

15 Oct 2021

Efficacy News and Research

New findings may help widen therapeutic interventions for B-cell acute lymphoblastic leukemia

Lactoferrin supplements could be used as adjunct for COVID-19 and other respiratory tract infections

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

COVID-19 vaccine breakthrough infections among immunocompromised individuals

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

Waning COVID vaccine efficacy especially against reinfection

Study: Funny memes may help people cope with COVID-19 stress

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

High levels of cancer-fighting immune cells could indicate a better chance of survival

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

Novel combination therapy identified for the brain metastases of breast cancer

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

What will it take to boost vaccinations? The scene from Kentucky’s back roads

Use of wearable and wireless inertial sensor systems for treating movement disorders

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

New class of CXCR4 antagonists could prevent airway inflammation and atopic dermatitis

Engineered 3D scaffolds of human brown adipose tissue as a new therapeutic strategy for obesity and diabetes

Pandemic-related grief associated with lower levels of mother-infant bonding

Zinc oxide in sunscreens destroys UVA protection during sun exposure

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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