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Negligible ACE2 expression in human beta-cells

Now, a new study published on the preprint server bioRxiv reports that even though the fatality rate is significantly higher in diabetics, there is no evidence that this is due to direct viral infection of pancreatic beta cells, which produce the key hormone in glucose homeostasis, namely insulin.

1 Sep 2020

Excessive immune response plays an important role in severe Covid-19

The team from Marien Hospital and the department of Virology of Ruhr-Universität Bochum (RUB) as well as the Clinic for Infectious Diseases, the Clinic of Anesthesiology and the Institute for Virology of University Medicine Essen studied specific antibodies and T cells occurring in recovered, seriously ill and deceased Covid-19 patients.

1 Sep 2020

Promising new candidate 'virus-like particle' vaccine for COVID-19

Researchers in the UK and Taiwan have demonstrated the potential of a new candidate vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the virus responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

1 Sep 2020

Human antibody response to SARS-CoV-2

A new study published on the preprint server medRxiv* in August 2020 reports on the human antibody response in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which is key to developing vaccines and managing the pandemic, as well as designing and executing serologic testing and interpreting their results.

1 Sep 2020

Spike ferritin nanoparticles show potential as SARS-CoV-2 vaccine

Now, a new study published on the preprint server bioRxiv* in August 2020 reports the induction of neutralizing antibodies in mice by a single dose of a ferritin nanoparticle-based vaccine containing the spike protein.

1 Sep 2020

Unique antibody profile differentiates people with non-celiac gluten sensitivity

A new study of the antibodies produced by people with gluten sensitivity may lead to a better way to detect the condition and treat it.

31 Aug 2020

A nanoscaffolding approach for rapid design of highly immunogenic SARS-CoV-2 vaccines

A research group from Slovenia, Switzerland, and Germany shows how nanoscaffolded assemblies may neutralize interaction between the SARS-CoV-2 spike protein and cell receptor, providing adequate protection in a surrogate infection assay and warranting the advance of such platforms in the pursuit for the effective vaccine.

31 Aug 2020

T cell epitopes from recovered COVID-19 patients identified for vaccine

A new study by researchers at The Hong Kong University of Science and Technology and published on the preprint server bioRxiv in August 2020 collates the available database of SARS-CoV-2 T cell epitopes gathered from 8 studies of COVID-19 patients who recovered. This could serve as a launchpad to fill in knowledge gaps regarding the immunological aspects of this disease, and drive towards an effective T cell vaccine.

31 Aug 2020

Rabbits susceptible to SARS-CoV-2: Red flag for potential virus reservoir

A new study by scientists in the Netherlands and published on the preprint server bioRxiv* in August 2020 shows that the severe acute respiratory coronavirus-2 (SARS-CoV-2) can infect rabbits, which opens the door for possible circulation in rabbit farms and another potential source of animal to human SARS-CoV-2 infection. This finding calls for urgent research on the prevalence of the virus in farmed rabbits.

30 Aug 2020

Using SARS-CoV-2 epitope to construct a vaccine

A new study published on the preprint server bioRxiv* in August 2020 reports the use of prediction and advanced simulation techniques to identify a novel T cell epitope on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could serve as the basis for a customized vaccine with broad-based efficacy.

30 Aug 2020

Scientists describe known approaches for treatment of SARS-CoV-2 infection

Researchers from Sechenov University together with Russian and Iranian colleagues described currently known approaches to the treatment of SARS-CoV-2 infection.

29 Aug 2020

Thomas Jefferson University receives grant for the development of CoraVax

The Commonwealth of Pennsylvania has announced grants totaling $10M to 23 entities to develop effective COVID-19 vaccines, treatments and therapies.

28 Aug 2020

Study shows the need to refine COVID-19 testing criteria to include children with GI symptoms

Over 1,000 children from Northern Ireland, Scotland, England and Wales, known as 'COVID Warriors' have had their antibodies measured in the UK-wide trial called 'Seroprevalence of SARS-Cov-2 infection in healthy children'.

28 Aug 2020

COVID + influenza: This is a good year to get a flu shot, experts advise

Flu season will look different this year, as the country grapples with a coronavirus pandemic that has killed more than 172,000 people. Many Americans are reluctant to visit a doctor's office and public health officials worry people will shy away from being immunized.

28 Aug 2020

Researchers develop advanced imaging technique to visualize effects of valencies on B cell responses

Designing a vaccine starts with finding the right ingredients. Every infectious agent has molecules, called antigens, that the immune system could potentially recognize and attack. So scientists must carefully consider which antigens should go into a vaccine.

28 Aug 2020

Mouse-adapted SARS-CoV-2 model helps advance the development of COVID-19 vaccines

A new COVID-19 mouse model developed at the University of North Carolina at Chapel Hill captures many of the features of human disease and has helped advance a COVID-19 vaccine candidate to clinical trial.

27 Aug 2020

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

In a recent bioRxiv* preprint paper, researchers from the United States demonstrate the pivotal role the furin cleavage site insertion in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein plays in viral replication and pathogenesis – highlighting, in turn, the need for mutation monitoring when developing therapeutics and vaccines.

27 Aug 2020

5 things to know about convalescent blood plasma

President Donald Trump told the American people this week that convalescent plasma is a potential new treatment for COVID-19.

27 Aug 2020

New diagnostic tool can predict cancer patients' response to immunotherapy

A new diagnostic tool that can predict whether a cancer patient would respond to immunotherapy treatment has been developed by scientists at the University of Bath.

27 Aug 2020

Dotmatics announces the launch of Bioregister 2020.1

Dotmatics Ltd, a scientific informatics software and services company that is driving the automation of laboratory data workflows for scientific discovery and innovation research, today announced the introduction of Bioregister 2020.1, the latest version of its web-based application for registering sequence-based, chemically modified and structure-less biological entities.

27 Aug 2020