Clinical Trial News and Research

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Clinical trial: Oral drug improves exercise capacity in teens with congenital heart defects

The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects.

17 Nov 2019

Researchers evaluate potential of FMT, pre- and probiotics to treat Parkinson's patients

Constipation is a common complaint in patients with Parkinson's disease. Fecal microbiome transplantation and pre- and probiotics are potential options for treating constipation and restoring the microbiome of patients with Parkinson's disease, but scientists warn that clinical data are scarce, and more research is needed before supporting their use.

15 Nov 2019

Study shows importance of targeted antibody treatment for patients with wet macular degeneration

Wet age-related macular degeneration is one of the leading causes of blindness in the U.S. Breakthrough treatments come with a steep price tag and treatment burden for the patient, but a new study suggests their benefits to patient health and society top billions of dollars, or more, if adherence could be improved.

15 Nov 2019

Broccoli's effects on kidney health may depend on individual's genetics

New research indicates that the benefits of a dietary compound on kidney health may depend on an individual's genetics. The findings, which appear in an upcoming issue of JASN, may be helpful for tailoring interventions to prevent or treat kidney disease.

15 Nov 2019

Shared care model for early follow-up of breast cancer survivors

Survivors of early breast cancer will take part in a new nationwide study trialing a shared care model between cancer specialists and GPs for the follow-up care when they have completed their initial treatment.

15 Nov 2019

New study aims to optimize brain development in babies with congenital heart disease

An upcoming clinical trial at Children's National Hospital will harness cardiopulmonary bypass as a delivery mechanism for a novel intervention designed to stimulate brain growth and repair in children who undergo cardiac surgery for congenital heart disease.

14 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

New type of bionic pacemaker

A new study published in the Journal of Physiology on November 14, 2019, reports the development of a radically different type of cardiac pacemaker which could change the prognosis of patients with heart failure.

14 Nov 2019

FDA grants acceptance to application for selumetinib as treatment for neurofibromatosis

AstraZeneca and MSD (Merck) announced today that the U.S. Food and Drug Administration (FDA) has granted acceptance to file status of its application for the MEK inhibitor selumetinib, for use in patients with plexiform neurofibromas, a common manifestation in the disease neurofibromatosis type one (NF1).

14 Nov 2019

Researchers develop, test new blood assay that predicts patients at risk of death from sepsis

After decades of little or no progress, biomedical researchers are finally making some headway at detecting and treating sepsis, a deadly medical complication that sends a surge of pathogenic infection through the body and remains a major public health problem.

14 Nov 2019

Simple 'nudges' help improve heart patients' adherence to statins

Statins are an effective medication for treating patients with heart disease - they cut the risk of a second major adverse cardiac event by almost 50 percent. But only about six percent of patients take statins as prescribed. One way to solve that? Nudge them. Literally.

14 Nov 2019

First Ebola vaccine prequalified by WHO for use in high-risk countries

The world's first Ebola vaccine has been prequalified by the World Health Organization (WHO).

14 Nov 2019

Secondary surgery for recurrent ovarian cancer patients does not result in longer survival

Researchers from The University of Texas MD Anderson Cancer Center reported that secondary tumor-reduction, or cytoreduction, surgery followed by chemotherapy did not result in longer survival than chemotherapy alone in patients with platinum-sensitive recurrent ovarian cancer.

13 Nov 2019

Inhaled immunosuppressant could improve prognosis of lung transplant patients

University of Maryland School of Medicine researchers found that lung transplant recipients who had early signs of organ rejection could increase their chances of survival by using an inhaled form of the immunosuppression drug cyclosporine.

13 Nov 2019

Study shows potential of phage therapy to treat alcoholic liver disease

Bacteriophages (phages) are viruses that specifically destroy bacteria. In the early 20th century, researchers experimented with phages as a potential method for treating bacterial infections.

13 Nov 2019

Study offers significant contribution for recovery of motor functions

Delivering a diversified electric message to the different fibres of the injured spinal cord through a new technology able to deliver it in a targeted and independent manner. What is the result? Greater efficiency in recovering the control of voluntary limb movements in the event of serious damage to the spinal cord.

13 Nov 2019

Novartis announces strategy to broaden patient reach and availability of medicines in sub-Saharan Africa

Novartis announced today a new strategy to broaden patient reach and availability of its portfolio of medicines in sub-Saharan Africa, which is home to the largest underserved patient population in the world.

13 Nov 2019

Certain brain regions must be intact in stroke survivors with aphasia for successful speech entrainment

In an article in Brain, researchers at the Medical University of South Carolina (MUSC) and elsewhere report which brain regions must be intact in stroke survivors with aphasia if they are to perform well in a speech entrainment session, successfully following along with another speaker.

12 Nov 2019

Cardiac resynchronization therapy improves heart function in cancer survivors

A pacemaker-like device restored heart function in a group of cancer survivors -- mostly women with breast cancer -- who had suffered from heart failure as a result of chemotherapy treatment, a study in the Journal of the American Medical Association reports.

12 Nov 2019

New clinical trial aims to reduce malnutrition among patients with lung cancer

A new clinical trial at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute aims to reduce malnutrition among patients with lung cancer by offering nutritional counseling and medically tailored meals to at-risk patients.

12 Nov 2019

Clinical Trial News and Research

Clinical trial: Oral drug improves exercise capacity in teens with congenital heart defects

Researchers evaluate potential of FMT, pre- and probiotics to treat Parkinson's patients

Study shows importance of targeted antibody treatment for patients with wet macular degeneration

Broccoli's effects on kidney health may depend on individual's genetics

Shared care model for early follow-up of breast cancer survivors

New study aims to optimize brain development in babies with congenital heart disease

Research explains why immunotherapy fails against prostate cancer bone metastases

New type of bionic pacemaker

FDA grants acceptance to application for selumetinib as treatment for neurofibromatosis

Researchers develop, test new blood assay that predicts patients at risk of death from sepsis

Simple 'nudges' help improve heart patients' adherence to statins

First Ebola vaccine prequalified by WHO for use in high-risk countries

Secondary surgery for recurrent ovarian cancer patients does not result in longer survival

Inhaled immunosuppressant could improve prognosis of lung transplant patients

Study shows potential of phage therapy to treat alcoholic liver disease

Study offers significant contribution for recovery of motor functions

Novartis announces strategy to broaden patient reach and availability of medicines in sub-Saharan Africa

Certain brain regions must be intact in stroke survivors with aphasia for successful speech entrainment

Cardiac resynchronization therapy improves heart function in cancer survivors

New clinical trial aims to reduce malnutrition among patients with lung cancer

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