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Researchers develop nanoparticles delivering STING agonists for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors––those that respond to immunotherapy––by awakening and enlisting the body's own immune system.

30 Sep 2021

Moderna vaccine reduced viral load and protected against SARS-CoV-2 variants in new phase 3 trial

Coronavirus research has shown that higher viral loads are associated with severe COVID-19 infection. But new results from the phase III Coronavirus Efficacy (COVE) clinical trial find the Moderna vaccine reduces severe acute respiratory coronavirus 2 (SARS-CoV-2) viral load and viral shedding.

30 Sep 2021

Scientists use new technique to study the effects of reactive electrophilic drugs

In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple sclerosis, inflammation damages the protective myelin insulation around nerves, and the nerves themselves.

30 Sep 2021

Direct-to-consumer machine learning model incorrectly classifies rare, aggressive skin cancers

A new study has found that a direct-to-consumer machine learning model for detecting skin cancers incorrectly classified rare and aggressive cancers as low-risk.

30 Sep 2021

New drug combination effectively suppresses SARS-CoV-2 infection

More countries with greater resources are opening up for a more normal life. But COVID-19 and the SARS-CoV-2 virus are still a significant threat in large parts of the world.

30 Sep 2021

Researchers develop novel antibacterial material for wound dressing

Researchers at the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) and the Technical University of Liberec in collaboration with researchers from the Institute of Microbiology of the CAS, the Department of Burns Medicine of the Third Faculty of Medicine at Charles University (Czech Republic), and P. J. Šafárik University in Košice (Slovakia) have developed a novel antibacterial material combining nonwoven nanotextile and unique compounds with antibacterial properties.

30 Sep 2021

The applications of nanomaterials against viral disease

The application of nanomaterials in the diagnosis, prevention, and treatment of viral diseases is reviewed in detail, highlighting areas of significant progress or stagnation from the past few decades.

30 Sep 2021

Diverse vaccine attitudes amongst UK healthcare workers suggest hesitancy may remain after vaccine acceptance

In a recent paper, the phenomenon of vaccine hesitancy is further explored amongst UK healthcare workers.

30 Sep 2021

ACTG to present data highlighting a new therapeutic for COVID-19 at the virtual IDWeek 2021

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that Teresa H. Evering, M.D., M.S., a co-lead investigator (with Eric S. Daar, M.D.) for BRII-196/BRII-198 in the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies, will present data for the monoclonal antibody combination at the virtual IDWeek 2021 conference, taking place September 29 – October 3, 2021.

30 Sep 2021

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Now, in a new news study posted to the bioRxiv* preprint server, researchers have successfully induced similar chronicity associated with SARS-CoV-2 infection in MISTRG6-hACE2 humanized mice.

29 Sep 2021

New 'priming' approach may improve the efficacy of chemotherapy for pancreatic cancer

A new approach to 'prime' the tumor environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer.

29 Sep 2021

Columbia University and partners launch and operate New York City's first Pandemic Response Institute

Through a groundbreaking new award from New York City Economic Development Corporation (NYCEDC), Columbia University – through its Mailman School of Public Health – and a consortium of academic, community, government, and corporate partners will launch and operate New York City's first Pandemic Response Institute (PRI).

29 Sep 2021

A review of COVID-19 vaccine effectiveness

A new study systematically reviews vaccine efficacy and vaccine effectiveness (VE) of COVID-19 vaccines.

29 Sep 2021

Ketamine use on patients with excited delirium and cocaine intoxication increases intubation rate

Patients with excited delirium who are combative, aggressive or agitated before being transported to the hospital or in an emergency department setting require immediate treatment for their safety and others.

29 Sep 2021

Large-scale SARS-CoV-2 spike protein mutants analysis identifies subclonal variants indicative of within-host viral diversity

Researchers have investigated a vast SARS-CoV-2 assembly and NGS data set to detect non-synonymous S protein mutations.

29 Sep 2021

Study finds correlation between neutralizing antibody titer and reported vaccine efficacy

An observational study compares immune responses against three vaccines.

29 Sep 2021

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

How effective are COVID-19 vaccines against SARS-CoV-2 variants of concern?

The authors from this paper performed a systematic review and meta-analysis evaluating vaccine effectiveness from RCTs and observational studies.

29 Sep 2021

Greater viral load of SARS-CoV-2 variants of concern increases transmission potential

By quantifying the probability of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in accordance with its viral load after a high-risk contact, researchers from France, Spain, and the United Kingdom show a substantial correlation of transmission probability and viral load increase in variants of concern.

28 Sep 2021

Quantification of antibody titers against SARS-CoV-2 variants elicited by BNT162b2 vaccine

A new study discusses the development of dedicated reagents against the SARS-CoV-2 spike protein through the use of an automated CLEIA system.

28 Sep 2021

Efficacy News and Research

Researchers develop nanoparticles delivering STING agonists for intravenous cancer immunotherapy

Moderna vaccine reduced viral load and protected against SARS-CoV-2 variants in new phase 3 trial

Scientists use new technique to study the effects of reactive electrophilic drugs

Direct-to-consumer machine learning model incorrectly classifies rare, aggressive skin cancers

New drug combination effectively suppresses SARS-CoV-2 infection

Researchers develop novel antibacterial material for wound dressing

The applications of nanomaterials against viral disease

Diverse vaccine attitudes amongst UK healthcare workers suggest hesitancy may remain after vaccine acceptance

ACTG to present data highlighting a new therapeutic for COVID-19 at the virtual IDWeek 2021

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

New 'priming' approach may improve the efficacy of chemotherapy for pancreatic cancer

Columbia University and partners launch and operate New York City's first Pandemic Response Institute

A review of COVID-19 vaccine effectiveness

Ketamine use on patients with excited delirium and cocaine intoxication increases intubation rate

Large-scale SARS-CoV-2 spike protein mutants analysis identifies subclonal variants indicative of within-host viral diversity

Study finds correlation between neutralizing antibody titer and reported vaccine efficacy

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

How effective are COVID-19 vaccines against SARS-CoV-2 variants of concern?

Greater viral load of SARS-CoV-2 variants of concern increases transmission potential

Quantification of antibody titers against SARS-CoV-2 variants elicited by BNT162b2 vaccine

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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