Therapeutics News and Research

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PARP inhibitors show promise for treating and preventing brain disorders

A class of cancer drugs called PARP inhibitors could be useful for treating and preventing brain disorders, including amyotrophic lateral sclerosis, also called Lou Gehrig's disease, and some forms of frontotemporal degeneration, by halting the misplacement of specific proteins that affect nerve cells, according to a study published in Molecular Cell by researchers in the the School of Arts and Sciences and the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2018

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

HIV-1 replicates in ninja-like ways. The virus slips through the membrane of vital white blood cells. Inside, HIV-1 copies its genes and scavenges parts to build a protective bubble for its copies.

10 Aug 2018

One-two punch of powerful antibodies may be best way to stop Ebola virus

A one-two punch of powerful antibodies may be the best way to stop Ebola virus, reports an international team of scientists in the journal Cell.

10 Aug 2018

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier.

10 Aug 2018

RCSI and Bayer collaborate to improve treatments for people with hemophilia

RCSI and Bayer have today announced a research collaboration that aims to improve treatments for people with severe haemophilia.

9 Aug 2018

Researchers describe new class of potent inhibitors against amyloid plaques

Effective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available.

9 Aug 2018

Study reveals cellular pathway used by Ebola virus to enter cells

A new study at Texas Biomedical Research Institute is shedding light on the role of specific proteins that trigger a mechanism allowing Ebola virus to enter cells to establish replication.

9 Aug 2018

New findings pave way for novel, improved drugs to treat psychiatric disorders

Researchers at Columbia University Irving Medical Center have found new evidence of how certain transport proteins are working at the molecular level, paving the way for new, improved drugs to treat psychiatric disorders.

9 Aug 2018

Study: Exercise can help prevent relapses into cocaine addiction

Exercise can help prevent relapses into cocaine addiction, according to new research led by the University at Buffalo's Panayotis (Peter) Thanos, PhD.

9 Aug 2018

Beat Childhood Cancer consortium's clinical trial offers new hope to children in Canada

Children in Canada who are battling neuroblastoma, a form of cancer, have been granted new hope toward a better prognosis and long-term survival.

8 Aug 2018

Scientists create new tool to precisely control 3D architecture of linkages in drugs

When it comes to certain molecules, shape makes all the difference. The shape of limonene, for instance, a compound produced by citrus fruits, determines whether it tastes like orange juice or turpentine.

7 Aug 2018

Study: Potential new class of drugs may lower heart disease risk by targeting gut microbes

Cleveland Clinic researchers have designed a potential new class of drugs that may reduce cardiovascular risk by targeting a specific microbial pathway in the gut.

7 Aug 2018

Researchers develop drug-delivery system that allows rapid response to heart attacks

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a drug-delivery system that allows rapid response to heart attacks without surgical intervention.

7 Aug 2018

Scientists develop novel peptide drug that could potentially stop development of liver cancer

A research team led by scientists from the Cancer Institute of Singapore at the National University of Singapore has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer.

2 Aug 2018

Innovative 'EvolvR' system lets scientists shuffle genes until they get right variation

Scientists at the Innovative Genomics Institute have concocted a transformative new way to harness the power of evolution.

2 Aug 2018

RBC-hitchhiking method increases concentration of drugs ferried to selected organs

A new drug-delivery technology which uses red blood cells to shuttle nano-scale drug carriers, called RBC-hitchhiking, has been found in animal models to dramatically increase the concentration of drugs ferried precisely to selected organs, according to a study published in Nature Communications this month by researchers from the Perelman School of Medicine at the University of Pennsylvania.

2 Aug 2018

UH researchers awarded $2 million grant to unravel link between women and lupus

The chronic inflammatory disease systemic lupus erythematosus, is about nine times more common in women than men, and a University of Houston researcher now has the money to find out why.

1 Aug 2018

Researchers characterize production process for standardized monoclonal antibody

Researchers have taken the first step towards developing a method for the production of a standardized monoclonal antibody (mAb).

1 Aug 2018

Researchers engineer three cell lines to produce nonproprietary versions of NISTmAb

When the National Institute of Standards and Technology issued the world's first standardized monoclonal antibody in July 2016, the exhaustively analyzed protein known as NISTmAb was intended as a valuable tool for biopharmaceutical companies.

1 Aug 2018

Study projects global lung cancer mortality rates among women to increase by 43% by 2030

The global age-standardized lung cancer mortality rate among women is projected to increase by 43 percent from 2015 to 2030, according to an analysis of data from 52 countries. The global age-standardized breast cancer mortality rate is projected to decrease by 9 percent in the same time frame.

1 Aug 2018

Therapeutics News and Research

PARP inhibitors show promise for treating and preventing brain disorders

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

One-two punch of powerful antibodies may be best way to stop Ebola virus

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

RCSI and Bayer collaborate to improve treatments for people with hemophilia

Researchers describe new class of potent inhibitors against amyloid plaques

Study reveals cellular pathway used by Ebola virus to enter cells

New findings pave way for novel, improved drugs to treat psychiatric disorders

Study: Exercise can help prevent relapses into cocaine addiction

Beat Childhood Cancer consortium's clinical trial offers new hope to children in Canada

Scientists create new tool to precisely control 3D architecture of linkages in drugs

Study: Potential new class of drugs may lower heart disease risk by targeting gut microbes

Researchers develop drug-delivery system that allows rapid response to heart attacks

Scientists develop novel peptide drug that could potentially stop development of liver cancer

Innovative 'EvolvR' system lets scientists shuffle genes until they get right variation

RBC-hitchhiking method increases concentration of drugs ferried to selected organs

UH researchers awarded $2 million grant to unravel link between women and lupus

Researchers characterize production process for standardized monoclonal antibody

Researchers engineer three cell lines to produce nonproprietary versions of NISTmAb

Study projects global lung cancer mortality rates among women to increase by 43% by 2030

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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