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Newly-discovered mutation highlights complex genetic network that underpins blood disorder

Porphyrias, a group of eight known blood disorders, affect the body's molecular machinery for making heme, which is a component of the oxygen-transporting protein, hemoglobin. When heme binds with iron, it gives blood its hallmark red color.

7 Sep 2017

Effects of obesity on U.S. population health may be more pervasive than previously understood

Considering weight across the life course, the prevalence of obesity among adults in the US rises considerably, suggesting that the effects on population health may be even more pervasive than previously understood, according to a new study led by a Boston University School of Public Health researcher.

6 Sep 2017

Reduced dose of chemotherapy has no effect on overall survival of liver cancer patients

Patients with the most common type of liver cancer who are taking the chemotherapy drug sorafenib can begin their treatment with a lower dose than is currently considered standard, and it will not affect how long they live when compared to patients who start on the full dose.

6 Sep 2017

Collaborative care model can expand access to treatment for opioid or alcohol addiction

Combining substance abuse treatment with regular medical care can successfully treat people with opioid or alcohol addiction, providing an option that might expand treatment and lower the cost of caring for people caught up in the nation's opioid epidemic, according to a new RAND Corporation study.

6 Sep 2017

Ketogenic diet prolongs life and improves memory and physical functions in aged mice find researchers

A pair of new studies find that diets termed ketogenic that are classically low in carbohydrates can prolong life in adult male laboratory mice. In addition this ketogenic diet also preserves the memory functions as well as muscle masses of the aged mice that were fed on it. The mechanism behind this could be the fact that ketogenic diet induces protein acetylation in the mice liver and muscles.

5 Sep 2017

Unfolded protein response could be cause of metabolic disorders, say researchers

The cell's response to unfolded or misfolded proteins could be a cause, rather than a consequence, of metabolic disorders, report researchers at the Medical University of South Carolina in an article published online ahead of print on September 4, 2017 by Nature Structural & Molecular Biology.

4 Sep 2017

Loyola Medicine reaches another major milestone with successful first pancreas transplant

Loyola Medicine's solid organ transplant program has reached another major milestone with the successful performance of its first pancreas transplant.

4 Sep 2017

Hepatitis A outbreak among population of San Diego

The San Diego population is facing one of the worst outbreaks of infective viral disease Hepatitis A. the outbreak began last November and is still going strong with no signs of reduction in the infection rates. The homeless are one of the worst hit.

3 Sep 2017

FDA approves drug to treat patients with newly diagnosed CD33-positive AML

The U.S. Food and Drug Administration today approved Mylotarg (gemtuzumab ozogamicin) for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors express the CD33 antigen (CD33-positive AML).

1 Sep 2017

Pfizer receives FDA approval for new therapy to treat adults and children with AML

Pfizer Inc. today announced that the U.S. Food and Drug Administration approved MYLOTARG (gemtuzumab ozogamicin) for adults with newly diagnosed CD33-positive acute myeloid leukemia (AML), and adults and children 2 years and older with relapsed or refractory CD33-positive AML.

1 Sep 2017

New study offers insights on mechanisms behind development of kidney damage due to obesity

A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to a potential target for protecting the kidney health of individuals with obesity.

1 Sep 2017

Some thyroid cancer patients can safely delay surgery

Most people diagnosed with cancer want to start treatment as soon as possible, for fear that delaying care will allow their tumor to grow out of control.

31 Aug 2017

New drug shows promise to treat women with estrogen positive metastatic breast cancer

Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease.

31 Aug 2017

Researchers use biochemical validation to verify claims of smoking cessation

According to a recent study led by The University of Kansas Cancer Center researchers, a high proportion of smokers enrolled in bedside tobacco cessation programs who said they had quit were misreporting their smoking status.

29 Aug 2017

Placenta-on-a-chip device mimics microenvironment of malaria in the womb to develop treatments

Malaria, one of the most severe public health problems, affected 212 million people worldwide in 2015. This life-threatening disease is caused by parasites that are transmitted to humans through the bites of infected female Anopheles mosquitoes.

29 Aug 2017

First-in-class investigational drug lowers LDL cholesterol for up to one year, study finds

Inclisiran lowers low-density lipoprotein (LDL; "bad") cholesterol for up to one year in patients with high cardiovascular risk and elevated LDL cholesterol, according to late-breaking results from the ORION 1 trial presented today in a Hot Line LBCT Session at ESC Congress.

29 Aug 2017

Coffee consumption connected to a longer life

At the European Society of Cardiology, ESC Congress 1 last weekend, Spanish researchers working as part of the long term project Seguimiento Universidad de Navarra (SUN) Project, presented their new study that suggests coffee intake might be tied to a longer life. The study included around 20,000 Spanish participants.

28 Aug 2017

SLU-led project receives NIH funding for clinical trial on potential treatment for MDR-TB

Saint Louis University is leading a multi-national clinical trial of what could become a regimen for drug resistant tuberculosis (TB) that does not require injectable medications. The project is funded by a $6.4 million task order from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

26 Aug 2017

Junk genes could one day offer framework for treating people with familial hypercholesterolemia

Scientists from UCLA and the Howard Hughes Medical Institute successfully used a gene that suppresses cholesterol levels as part of a treatment to reduce plaque in mice with a disorder called familial hypercholesterolemia.

26 Aug 2017

LSU Health New Orleans receives $10 million grant to support research on virus-induced cancers

The National Institute of General Medical Sciences has awarded LSU Health New Orleans a $10 million grant over five years to support new basic research studies advancing the development new diagnostic and therapeutic approaches for virus-induced cancers.

26 Aug 2017

Liver News and Research

Newly-discovered mutation highlights complex genetic network that underpins blood disorder

Effects of obesity on U.S. population health may be more pervasive than previously understood

Reduced dose of chemotherapy has no effect on overall survival of liver cancer patients

Collaborative care model can expand access to treatment for opioid or alcohol addiction

Ketogenic diet prolongs life and improves memory and physical functions in aged mice find researchers

Unfolded protein response could be cause of metabolic disorders, say researchers

Loyola Medicine reaches another major milestone with successful first pancreas transplant

Hepatitis A outbreak among population of San Diego

FDA approves drug to treat patients with newly diagnosed CD33-positive AML

Pfizer receives FDA approval for new therapy to treat adults and children with AML

New study offers insights on mechanisms behind development of kidney damage due to obesity

Some thyroid cancer patients can safely delay surgery

New drug shows promise to treat women with estrogen positive metastatic breast cancer

Researchers use biochemical validation to verify claims of smoking cessation

Placenta-on-a-chip device mimics microenvironment of malaria in the womb to develop treatments

First-in-class investigational drug lowers LDL cholesterol for up to one year, study finds

Coffee consumption connected to a longer life

SLU-led project receives NIH funding for clinical trial on potential treatment for MDR-TB

Junk genes could one day offer framework for treating people with familial hypercholesterolemia

LSU Health New Orleans receives $10 million grant to support research on virus-induced cancers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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