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Research may help advance search for more effective drugs to treat Alzheimer's disease

Two new studies published by investigators from Brigham and Women's Hospital illustrate that not all forms of amyloid-beta protein - the protein thought to initiate Alzheimer's disease - play an equally menacing role in the progress of the disease.

31 Jul 2018

Researchers investigate new treatment that is effective against recurrent breast cancers

What do one in five breast cancers have in common? Large amounts of a protein called HER2 (or human epidermal growth factor receptor 2).

30 Jul 2018

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the Committee for Medicinal Products for Human Use has adopted a Positive Opinion recommending marketing authorization of patisiran for the treatment of hereditary transthyretin-mediated amyloidosis in adults with stage 1 or stage 2 polyneuropathy.

27 Jul 2018

Researchers discover new protein that controls level of inflammation-inducing molecule

One of the major therapeutic targets for inflammatory diseases is the inflammation-inducing molecule TNF. However, excess levels of TNF cause side effects and can lead to diseases.

27 Jul 2018

Researchers develop nano-carriers to specifically target senescent cells

Senescent cells are damaged cells that do not perform their normal roles anymore but that are not dead -hence they are commonly known as zombi cells.

27 Jul 2018

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Certara, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, announced today that Clinical Pharmacology & Therapeutics has published its "Letter to the Editor" describing the important role that quantitative systems pharmacology can play in defining dosing criteria for first-in-human clinical trials, together with the European Medicines Agency's response.

26 Jul 2018

Cutting-edge laboratory technique recapitulates brain development more accurately than ever

A cutting-edge laboratory technique that turns human stem cells into brain-like tissue now recapitulates human brain development more accurately than ever, according to a new study from Case Western Reserve University School of Medicine.

26 Jul 2018

Study reveals key role of actin cytoskeletal dynamics in supporting immune cell function

In order to move, a body needs a strong scaffold. This is not only true on a macroscopic level, where animals rely on skeletons to support their muscles.

26 Jul 2018

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

New research gives insights into how the design of clinical trials can improve to address the "critically low" research pipeline and improve the chances of finding effective dementia therapies.

26 Jul 2018

Research provides new roadmap for repairing damaged brain cells in multiple sclerosis

Research published today in the journal Nature provides new understanding about how drugs can repair damaged brain cells that cause disability in patients with multiple sclerosis.

26 Jul 2018

Omeros’ OMS721 receives positive opinion from EMA's COMP for treating hematopoietic stem cell transplant

Omeros Corporation announced today that the European Medicines Agency's Committee for Orphan Medicinal Products issued a positive opinion recommending orphan drug designation of OMS721 for treatment in hematopoietic stem cell transplantation.

25 Jul 2018

Kaia app reduces low back pain by 40%, could save billions for the UK economy

Low back pain is an increasingly widespread and expensive condition worldwide, and the World Health Organization has identified back pain as being the global number one reason for disability.

25 Jul 2018

AVITA Medical expands management team to support launch of RECELL device to treat burns

AVITA Medical today announced that it expanded its management team in the commercial, legal and medical affairs functions to support the planned U.S. launch of the RECELL® Autologous Cell Harvesting Device in the treatment of burns

20 Jul 2018

Using miniature drug-filled nanocarriers to target headaches and tumors

Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors.

20 Jul 2018

Top AI companies join hands to discover novel drugs for DMD

Insilico Medicine a leader in artificial intelligence for drug discovery, biomarker development and aging research, announced a research collaboration agreement with A2A Pharmaceuticals, Inc. A2A is a biotechnology company headquartered in New York and focused on development of novel drugs for unmet needs in oncology, drug resistant bacterial infections, and other life threatening diseases.

20 Jul 2018

Kite collaborates with Gadeta to develop novel gamma delta TCR therapies for various cancers

Kite, a Gilead Company, and Gadeta B.V., a privately-held company focused on the discovery and development of novel cancer immunotherapies based on gamma delta T cell receptors, have entered into a strategic collaboration to develop novel gamma delta TCR therapies in various cancers.

19 Jul 2018

Study finds link between DNA methylation and non-alcoholic fatty liver disease

DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But sometimes this process goes awry.

19 Jul 2018

Inflection Biosciences' dual mechanism inhibitor shows promise as treatment for CLL

Inflection Biosciences Ltd, a private company developing innovative therapeutics for cancer, today announced the publication of preclinical data showing the company's dual mechanism PIM/PI3 kinase inhibitor IBL-202 has promise as a treatment for chronic lymphocytic leukemia.

17 Jul 2018

Study highlights potential of fetal gene therapy to prevent lethal neurodegenerative disease

A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System in Singapore.

16 Jul 2018

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

16 Jul 2018

Therapeutics News and Research

Research may help advance search for more effective drugs to treat Alzheimer's disease

Researchers investigate new treatment that is effective against recurrent breast cancers

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Researchers discover new protein that controls level of inflammation-inducing molecule

Researchers develop nano-carriers to specifically target senescent cells

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Cutting-edge laboratory technique recapitulates brain development more accurately than ever

Study reveals key role of actin cytoskeletal dynamics in supporting immune cell function

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

Research provides new roadmap for repairing damaged brain cells in multiple sclerosis

Omeros’ OMS721 receives positive opinion from EMA's COMP for treating hematopoietic stem cell transplant

Kaia app reduces low back pain by 40%, could save billions for the UK economy

AVITA Medical expands management team to support launch of RECELL device to treat burns

Using miniature drug-filled nanocarriers to target headaches and tumors

Top AI companies join hands to discover novel drugs for DMD

Kite collaborates with Gadeta to develop novel gamma delta TCR therapies for various cancers

Study finds link between DNA methylation and non-alcoholic fatty liver disease

Inflection Biosciences' dual mechanism inhibitor shows promise as treatment for CLL

Study highlights potential of fetal gene therapy to prevent lethal neurodegenerative disease

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Next-generation therapeutics eBook eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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