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Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

Scientists have demonstrated a new way to investigate mechanisms at work in Alzheimer's and other neurodegenerative diseases, which also could prove useful in the search for effective drugs. For new insights, they turned to the zebrafish, which is transparent in the early stages of its life. The researchers developed a transgenic variety, the "MitoFish," that enables them to see - within individual neurons of living animals - how brain diseases disturb the transport of mitochondria, the power plants of the cell.

6 Dec 2012

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

The University of Florida (UF) has started enrolling subjects in a new study testing the oral drug developed by Sound Pharmaceuticals, Inc. (SPI-1005) to prevent hearing loss caused by loud music. Loud music or noise can induce temporary and permanent auditory threshold shifts (TTS or PTS).

6 Dec 2012

Nerve stimulation improves hand use in spinal cord injury patients

A method combining transcranial magnetic stimulation with electrical stimulation of peripheral nerves in the wrist temporarily improves hand use in spinal cord injury patients, show research findings published in Current Biology.

5 Dec 2012

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Selective targeting of the neurotransmitter that differentially affects brain cells that control the two distinct functions of the pancreas may allow for new medication therapies for conditions like diabetes, dyspepsia and gastro-esophageal reflux, according to Penn State College of Medicine researchers.

5 Dec 2012

Parasympathetic dysfunction underpins Gulf War Syndrome

Gulf War veterans with self-reported symptoms of autonomic dysfunction have objective evidence of underlying damage to central and peripheral cholinergic function, a study shows.

4 Dec 2012

Kona Medical completes Series C financing

Kona Medical, Inc. today announced it has completed its Series C financing with the addition of $10 million in equity and debt, bringing total proceeds to $40 million.

4 Dec 2012

Researchers discover first-ever mouse model of diffuse idiopathic skeletal hyperostosis

Researchers at Western University have made a breakthrough that could lead to a better understanding of a common form of arthritis that, until now, has eluded scientists.

4 Dec 2012

Obstructive sleep apnea affects women more severely than men

Women suffering from sleep apnea have, on the whole, a higher degree of brain damage than men with the disorder, according to a first-of-its-kind study conducted by researchers at the UCLA School of Nursing.

3 Dec 2012

Diabetes tests: an interview with Dr. Danielle Stowasser

Diabetes is a serious condition that causes high levels of glucose (a type of sugar) in the blood. There are three main types of diabetes: type 1 and type 2 diabetes, which are lifelong conditions, and gestational diabetes, which only occurs in women during pregnancy.

3 Dec 2012

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

The treatment of inflammatory pain can be improved by endogenous opioid peptides acting directly in injured tissue. Scientists at the Charité - Universitätsmedizin Berlin and the Université Paris Descartes showed that pain can be successfully treated by targeting immune and nerve cells outside the brain or spinal cord.

3 Dec 2012

Childhood trauma can leave permanent epigenetic marks on DNA

Abused children are at high risk of anxiety and mood disorders, as traumatic experience induces lasting changes to their gene regulation. Scientists from the Max Planck Institute of Psychiatry in Munich have now documented for the first time that genetic variants of the FKBP5 gene can influence epigenetic alterations in this gene induced by early trauma.

3 Dec 2012

Children with changes in bully genes have poor survival

In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.

3 Dec 2012

Low-level exposure to organophosphates affects neurological and cognitive function

Scientists have found that low-level exposure to organophosphates (OPs) produces lasting decrements in neurological and cognitive function. Memory and information processing speed are affected to a greater degree than other cognitive functions such as language.

2 Dec 2012

Reduced production of myelin may play role in development of mental illness: Study

Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness, according to researchers at the Graduate School of Biomedical Sciences at Mount Sinai School of Medicine.

1 Dec 2012

Pressure Right effectively reduces postdischarge nausea and vomiting

In its December 2012 issue, the Outpatient Surgery Magazine's product news section introduces Pressure Right, the longer-acting perioperative, (Rx) antiemetic prophylaxis medical device to its readers.

30 Nov 2012

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Scientists from the DZNE sites in G-ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease. The study is published in "EMBO Molecular Medicine".

30 Nov 2012

Tdap well tolerated in over-65s

Off-label use of tetanus–diptheria–acellular pertussis vaccine in senior patients results in no more adverse events than the tetanus and diphtheria vaccine, a US study shows.

30 Nov 2012

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Scientists at NYU Langone Medical Center have identified two genes involved in establishing the neuronal circuits required for breathing. They report their findings in a study published in the December issue of Nature Neuroscience.

30 Nov 2012

Stroke effects: an interview with Dr Ingvars Birznieks

Stroke often affects both our ability of our hands to feel and our ability to contract muscles. Sensory and motor functions are tightly linked.

30 Nov 2012

GM1 ganglioside effectively treats patients with Parkinson's disease

Treating Parkinson's disease patients with the experimental drug GM1 ganglioside improved symptoms and slowed their progression during a two and a half-year trial, Thomas Jefferson University researchers report in a new study published online November 28 in the Journal of the Neurological Sciences.

30 Nov 2012

Nerve News and Research

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

Nerve stimulation improves hand use in spinal cord injury patients

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Parasympathetic dysfunction underpins Gulf War Syndrome

Kona Medical completes Series C financing

Researchers discover first-ever mouse model of diffuse idiopathic skeletal hyperostosis

Obstructive sleep apnea affects women more severely than men

Diabetes tests: an interview with Dr. Danielle Stowasser

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

Childhood trauma can leave permanent epigenetic marks on DNA

Children with changes in bully genes have poor survival

Low-level exposure to organophosphates affects neurological and cognitive function

Reduced production of myelin may play role in development of mental illness: Study

Pressure Right effectively reduces postdischarge nausea and vomiting

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Tdap well tolerated in over-65s

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Stroke effects: an interview with Dr Ingvars Birznieks

GM1 ganglioside effectively treats patients with Parkinson's disease

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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