Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Protein p53 plays crucial role in coordinated growth of organ parts

In studies conducted on the fruit fly, researchers at IRB Barcelona headed by ICREA Professor Marco Milán have revealed that organs have the molecular mechanisms to control their proportions. In this process the protein p53 plays a crucial role. The study is published today in the prestigious journal PLoS Biology.

15 Dec 2010

Develogen enters license, collaboration agreement with MedImmune on insulin beta cell regeneration

Evotec AG today announced that via its subsidiary Develogen AG it has entered into a license and collaboration agreement with MedImmune (the global biologics unit of AstraZeneca), in the diabetes therapeutic area, with a particular focus on the regeneration of insulin producing beta cells. The license gives MedImmune exclusive access to a portfolio of research programs and represents the first deal executed by Evotec on beta cell regeneration assets and capabilities.

15 Dec 2010

Inhaled corticosteroids may cause diabetes

In a study published in the most recent issue of The American Journal of Medicine, researchers found that inhaled corticosteroids were associated with a 34% increase in the rate of diabetes onset and in the rate of diabetes progression. At the highest inhaled doses the risk increased by 64% in diabetes onset and 54% in diabetes progression.

15 Dec 2010

Medicaid budget challenges continue to plague states, threaten safety net

States across the country continue to face challenges related to their Medicaid budgets and their abilities to provide care to a growing population of poor and disabled people.

15 Dec 2010

Study links large waistline to increased risk of heart problems and type 2 diabetes

Researchers at Eastern Virginia Medical School’s Strelitz Diabetes Center and the school’s department of physiological sciences have published research showing a strong link between a large waistline and increased risk of Type 2 diabetes and cardiovascular disease.

14 Dec 2010

Diet linked to onset of mental illness

Changes in diet have been linked to a reduction of abnormal behaviors in mentally ill people or animals, but a Purdue University study shows that diet might also trigger the onset of mental illness in the first place.

14 Dec 2010

Reversible two-step binding mechanism to stop cancer cell growth

What makes cancer cells so dangerous is that they grow in an unregulated way and proliferate much faster than other cells. The proteasome, a large protein complex, plays a key role in this process: By breaking down used proteins for recycling, it clears the way for the next cycle.

14 Dec 2010

New positive data on Generex Oral-lyn published in Diabetes, Obesity and Metabolism

Generex Biotechnology Corporation announced today that the peer-reviewed scientific journal Diabetes, Obesity and Metabolism has published new positive data in respect of Generex Oral-lyn™, the Company's proprietary buccal insulin spray product.

13 Dec 2010

Researchers generate insulin-secreting pancreatic islet cells from human SSCs

Insulin-secreting pancreatic islet cells have been generated from human spermatogonial stem cells (SSCs) directly isolated from human testicular tissue, researchers reported today at the American Association of Cell Biology 50th Annual Meeting in Philadelphia.

13 Dec 2010

Men with type 1 diabetes could grow their own insulin-producing cells from testicular tissue, says GUMC

Men with type 1 diabetes may be able to grow their own insulin-producing cells from their testicular tissue, say Georgetown University Medical Center (GUMC) researchers who presented their findings today at the American Society of Cell Biology 50th annual meeting in Philadelphia.

13 Dec 2010

Obesity is associated with worse outcomes in patients with ER-positive/HER2-negative disease

Obesity was associated with worse overall and disease-free survival in women with operable breast cancer treated with adjuvant chemotherapy, but for the first time, researchers observed this finding in only a specific subset of patients - those with estrogen receptor (ER)-positive/HER2-negative disease.

10 Dec 2010

Silencing the TLR4 gene can prevent cardiovascular disease in diabetic patients

Silencing the TLR4 gene can stop the process which may lead to cardiovascular disease in diabetic patients. Researchers demonstrated that TLR4 plays a critical role in hyperglycaemic cardiac apoptosis, and that silencing the gene using specific small interfering RNA can prevent it.

10 Dec 2010

Insulin related calls to poison centers increase 279%

Annual calls to poison centers regarding insulin have skyrocketed by 279 percent over the past 10 years, according to a new study authored by medical professionals at four U.S. poison centers.

9 Dec 2010

New software predicts key information about nasal insulin treatment regimens in type 1 diabetes

A La Jolla Institute team, led by leading type 1 diabetes researcher Matthias von Herrath, M.D., has demonstrated the effectiveness of a recently developed computer model in predicting key information about nasal insulin treatment regimens in type 1 (juvenile) diabetes. Development of the software, the Type 1 Diabetes PhysioLab- Platform, was funded through the peer-reviewed grant program of the American Diabetes Association.

9 Dec 2010

New types of dietary fiber now under development

High-fiber foods are on the way to becoming tastier and more appealing to consumers thanks to new types of dietary fiber now under development. These consumer friendlier forms of fiber, which could be a boon to health, are the topic of an article in the current issue of Chemical & Engineering News, ACS' weekly newsmagazine.

9 Dec 2010

FDA clears Valeritas' V-Go Disposable Insulin Delivery Device

Valeritas, Inc., a medical technology company committed to the development and commercialization of innovative drug delivery solutions, announced today that the US Food and Drug Administration has cleared the company's V-Go Disposable Insulin Delivery Device for the continuous subcutaneous delivery of insulin in preset basal rates and with on-demand bolus dosing for adult patients requiring insulin.

8 Dec 2010

Roche completes enrollment in Herceptin SC Phase 3 trial for HER2-positive breast cancer

Halozyme Therapeutics, Inc. today announced that Roche has completed patient enrollment for the pivotal Phase 3 study of Herceptin SC (trastuzumab subcutaneous), a subcutaneous formulation that uses Halozyme's Enhanze™ technology (rHuPH20, recombinant human hyaluronidase).

7 Dec 2010

Study: Mixing exenatide with insulin provides better blood sugar control in type 2 diabetes patients

A new study finds that combining the newer diabetes drug exenatide with insulin provides better blood sugar control in patients with type 2 diabetes than insulin alone and helps promote weight loss.

7 Dec 2010

Merrion Pharmaceuticals announces oral drug delivery Feasibility and Option agreement

Merrion Pharmaceuticals Plc, a publicly listed product development company, today announced the commencement of an oral drug delivery Feasibility and Option agreement with one of the world's top ten biggest pharmaceutical companies. The agreement will evaluate the ability of Merrion's patented GIPET technology to boost the bioavailablity of three of the 'big pharma' company's compounds.

6 Dec 2010

Merck plans to acquire SmartCells

Today pharmaceutical company, Merck & Co., Inc. announced it will acquire SmartCells, Inc., a private biotech developing a glucose-responsive insulin whose proof-of-concept preclinical trials were partially funded by the Juvenile Diabetes Research Foundation.

4 Dec 2010

Insulin News and Research

Further Reading

Protein p53 plays crucial role in coordinated growth of organ parts

Develogen enters license, collaboration agreement with MedImmune on insulin beta cell regeneration

Inhaled corticosteroids may cause diabetes

Medicaid budget challenges continue to plague states, threaten safety net

Study links large waistline to increased risk of heart problems and type 2 diabetes

Diet linked to onset of mental illness

Reversible two-step binding mechanism to stop cancer cell growth

New positive data on Generex Oral-lyn published in Diabetes, Obesity and Metabolism

Researchers generate insulin-secreting pancreatic islet cells from human SSCs

Men with type 1 diabetes could grow their own insulin-producing cells from testicular tissue, says GUMC

Obesity is associated with worse outcomes in patients with ER-positive/HER2-negative disease

Silencing the TLR4 gene can prevent cardiovascular disease in diabetic patients

Insulin related calls to poison centers increase 279%

New software predicts key information about nasal insulin treatment regimens in type 1 diabetes

New types of dietary fiber now under development

FDA clears Valeritas' V-Go Disposable Insulin Delivery Device

Roche completes enrollment in Herceptin SC Phase 3 trial for HER2-positive breast cancer

Study: Mixing exenatide with insulin provides better blood sugar control in type 2 diabetes patients

Merrion Pharmaceuticals announces oral drug delivery Feasibility and Option agreement

Merck plans to acquire SmartCells

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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