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New discovery could lead to faster and more effective treatments for chronic health complications

A world-first discovery by researchers at Monash University and The University of Queensland could lead to faster and more effective treatments for chronic health complications, such as cardiovascular disease and cancer, with 'fluorescent' in vivo biosensors.

26 Jan 2021

Prostate cancer: Drug-resistant, metastasis-causing cells can produce exponentially growing tumors

The cover for issue 1 of Oncotarget features Figure 2, "Results in clinical trials," published in "Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer" by Blagoev, et al. which reported that most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered.

26 Jan 2021

Researchers develop method for presymptomatic COVID-19 detection

An encouraging new study by researchers at University College London, UK, reports the potential of a form of COVID-19 testing which can detect presymptomatic cases.

26 Jan 2021

G3BP proteins inhibit metabolic driver that plays a central role in cancers, neurological disorders

G3BP proteins inhibit the metabolic driver MTOR - a signaling protein that plays a central role in tumor diseases and developmental disorders of the brain. This is reported in this week´s issue of the renowned journal Cell.

26 Jan 2021

Hyperinflammatory conditions drive gender differences in COVID-19 severity and mortality

Recently researchers from India analyzed gender differences in COVID-19-related hyperinflammatory conditions resulting in mortality in Indian patients. The study is published on the preprint server, medRxiv*.

25 Jan 2021

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

Small cell lung cancer (SCLC) cells are missing a surface protein that triggers an immune response, allowing them to hide from one of the body's key cancer defenses, a new study led by UT Southwestern researchers suggests.

25 Jan 2021

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of growth of solid tumors and lung metastases in mouse models of melanoma.

25 Jan 2021

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor.

25 Jan 2021

New maintenance treatment for AML shows strong benefit for patients

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial for which Weill Cornell Medicine and NewYork-Presbyterian are trial sites.

22 Jan 2021

Combination therapy shows potential for treating lung cancer

Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment.

22 Jan 2021

A traditional Chinese medicine could help treat COVID‐19 symptoms

A team of researchers in China – at Guangzhou University of Chinese Medicine and Yunnan University of Chinese Medicine – recently explored the therapeutic properties of Yinqiao powder in treating COVID-19 symptoms. Their findings were recently published in Phytotherapy Research.

22 Jan 2021

Patient-specific model is needed to understand cancer cells and their impacts

Despite cancer being a leading cause of death worldwide, treatment options for many types of cancers remain limited. This is partly due to the in vitro tools used to model cancers, which cannot adequately predict the behavior of a cancer or its sensitivity to drugs.

22 Jan 2021

Genomic test has lower prognostic accuracy in minority patients with breast cancer

Black women have higher recurrence and mortality rates than non-Hispanic white women for certain types of breast cancer, according to a University of Illinois Chicago researcher's study published recently in JAMA Oncology.

22 Jan 2021

Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma

Chimeric Antigen Receptor T-cell therapy--CAR T--has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma.

22 Jan 2021

Researchers develop comprehensive framework to classify small-cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.

22 Jan 2021

New study helps understand molecular profile of tumors in cancer patients

Researchers from the University Hospitals in Zurich and Basel, ETH Zurich, University of Zurich and the pharmaceutical company Roche have set out to improve cancer diagnostics by developing a platform of state-of-the-art molecular biology methods.

21 Jan 2021

Dynamic, customized treatment approaches for gastroesophageal cancers may improve survival rates

A phase 2 clinical trial providing personalized treatments based on the genetic profile of metastatic tumors in gastroesophageal cancers has found that using customized treatment approaches, and adapting them over time as tumors become resistant, led to higher rates of survival compared to historical controls.

21 Jan 2021

New drug target valid for breast cancer as well as lymphoma

One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research.

21 Jan 2021

Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are rare hematologic malignancies of the bone marrow.

21 Jan 2021

AACR and MPM award three grants to support groundbreaking cancer research projects

Three grants for research that could transform cancer therapies have been awarded by the AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grants Program, an innovative partnership between the American Association for Cancer Research and the UBS Oncology Impact Fund managed by MPM Capital.

21 Jan 2021

Tumor News and Research

New discovery could lead to faster and more effective treatments for chronic health complications

Prostate cancer: Drug-resistant, metastasis-causing cells can produce exponentially growing tumors

Researchers develop method for presymptomatic COVID-19 detection

G3BP proteins inhibit metabolic driver that plays a central role in cancers, neurological disorders

Hyperinflammatory conditions drive gender differences in COVID-19 severity and mortality

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

New maintenance treatment for AML shows strong benefit for patients

Combination therapy shows potential for treating lung cancer

A traditional Chinese medicine could help treat COVID‐19 symptoms

Patient-specific model is needed to understand cancer cells and their impacts

Genomic test has lower prognostic accuracy in minority patients with breast cancer

Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma

Researchers develop comprehensive framework to classify small-cell lung cancer

New study helps understand molecular profile of tumors in cancer patients

Dynamic, customized treatment approaches for gastroesophageal cancers may improve survival rates

New drug target valid for breast cancer as well as lymphoma

Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

AACR and MPM award three grants to support groundbreaking cancer research projects

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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