Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are rare hematologic malignancies of the bone marrow. They can occur spontaneously or secondary to treatment for other cancers, so called therapy related disease, which is frequently associated with a mutation of the tumor suppressor gene TP53. Standard treatment for these patients includes hypomethylating agents such as azacitidine or decitabine but unfortunately outcomes are very poor.

Patients with TP53-mutant disease, which is roughly 10% to 20% of AML and de novo MDS cases, don't have many options for therapy with nondurable responses to standard therapy. There is clearly a need for new targeted therapies for this patient population."

David Sallman, M.D., Assistant Member, Malignant Hematology Department, Moffitt Cancer Center

Sallman is leading a national, multicenter clinical trial investigating a new therapy option for this group of patients. It builds upon the standard of care therapy, combining eprenetapopt (APR-246) with the chemotherapy azacitidine. Eprenetapopt is a first-in-class mutant p53 reactivator. It is infused in the body and induces cell death in TP53 mutant cancer cells. It also has a synergistic effect when combined with azacitidine, meaning not only do the drugs work well on their own but also together they provide an amplified response.

Results of the phase 1b/2 trial to determine the safety, recommended dose and efficacy of the combination therapy were published in the Journal of Clinical Oncology.

Fifty-five patients (40 MDS, 11 AML, 4 MDS/myeloproliferative neoplasms) with at least one TP53 mutation were treated. The overall response rate was 71% with 44% having a complete response (50% for MDS patients), meaning no sign of disease with return of normal blood cell production. The median overall survival for patients was 10.8 months. Patients who responded to treatment had significantly improved overall survival at 14.7 months. Additionally, 35% of patients were able to proceed with allogeneic stem cell transplantation with favorable outcomes versus historical outcomes in this patient population.

"The data is promising and supports the current phase 3, multicenter trial, which we hope will lead to FDA approval and a new much-needed treatment option for this patient population," said Sallman.

Source:
Journal reference:

Sallman, D.A., et al. (2021) Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes. Journal of Clinical Oncology. doi.org/10.1200/JCO.20.02341.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
You might also like... ×
COVID-19 outbreak in Mauritius dominated by new SARS-CoV-2 variant B.1.1.318