Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Study finds clear association between hemoglobin levels and key cardiovascular traits

A new study led by the University of Oulu in Finland refutes the belief that high hemoglobin levels are always desirable for health.

15 Jul 2021

Mice study identifies pathways that link high-fat diet to atherosclerosis

It's long been known that a high-fat diet can lead to clogged arteries, but we have only recently begun to learn in detail how the process works. A new study in experimental mice could go a long way to finding treatments to keep arteries open and flowing.

9 Jul 2021

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

A new article has been published in Cellular and Molecular Lifesciences, which focuses on the connection between host factors and the worsening of the COVID-19. Further, the impact of the virus on the host’s microbiome and secondary infection has also been studied.

8 Jul 2021

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

New research evaluating the drugs commonly used by rheumatoid arthritis patients suggests two combinations could reduce the risk of heart attack and strokes.

6 Jul 2021

EULAR Patient Research Partners join in new research project to advance treatment of psoriatic arthritis

Eleven Patient Research Partners (PRPs) from three organizations (EULAR, GRAPPA-EU, and EUROPSO) participate in the new research project HIPPOCRATES, ensuring the patients' perspective is preserved and prioritized in all research activities to maximize the project's impact.

2 Jul 2021

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.

25 Jun 2021

Bruker’s molecular phenomics research tools enable new insights into ‘long COVID’ and post-acute metabolic abnormalities

A clinical research collaboration on COVID-19 pheno-conversion and subsequent pheno-reversion has discovered transient and persistent systemic changes of the molecular signatures in patient blood samples three months after the acute COVID-19 disease phase.

From Bruker BioSpin Group 22 Jun 2021

New research identifies a link between the gut microbiome and strokes

A recent study demonstrates the impact of diets that are high in choline and trimethylamine on increasing stroke severity and functional deficits.

21 Jun 2021

New technique can measure metabolic process at the single-cell level

Understanding cellular metabolism - how a cell uses energy- could be key to treating a wide array of diseases, including vascular diseases and cancer.

18 Jun 2021

Gut microbiome impacts stroke severity and post-stroke functional impairment

New findings from Cleveland Clinic researchers show for the first time that the gut microbiome impacts stroke severity and functional impairment following stroke.

16 Jun 2021

Bone density scan can detect calcium build-up linked to higher risk of serious falls

The build-up of calcium in a major blood vessel is linked with a 39 per cent higher risk of serious falls in older women, new Edith Cowan University (ECU) research has found.

14 Jun 2021

Weight loss drug Wegovy approved by FDA

The U.S. Food and Drug Administration (FDA) has approved Wegovy (semaglutide) injection (2.4 mg once weekly) as a chronic weight management treatment in obese or overweight adults with a weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), when used along with calorie restriction and physical activity. Wegovy, is a more potent version of Novo Nordisk's diabetes drug semaglutide.

4 Jun 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner.

2 Jun 2021

Glycosylated hemoglobin can provide a useful estimate of atherosclerosis and cardiovascular events

The routine use of the glycosylated hemoglobin test to track blood sugar levels in the general population can identify individuals with more advanced atherosclerotic disease.

1 Jun 2021

Tsimane's brains experience less brain atrophy than Westerners as they age, indicates study

A team of international researchers has found that the Tsimane indigenous people of the Bolivian Amazon experience less brain atrophy than their American and European peers.

26 May 2021

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

Researchers use base editing to sustainably lower high LDL cholesterol levels

Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence.

19 May 2021

Abnormal blood levels of proteins linked to dementia, Alzheimer's disease

The development of dementia, often from Alzheimer's disease, late in life is associated with abnormal blood levels of dozens of proteins up to five years earlier, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health

18 May 2021

Study provides a better understanding of the complex interplay of ncRNAs with gene regulation

Researchers at the University of Eastern Finland have discovered previously unknown non-coding RNAs (ncRNAs) involved in regulating the gene expression of vascular endothelial growth factors (VEGF), the master regulators of angiogenesis.

6 May 2021