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Computer model could streamline design of protein degraders

A team of Weill Cornell Medicine investigators has developed a computer model that will help scientists more efficiently develop protein-destroying therapies, a newer type of treatment that is particularly promising for cancer.

27 Aug 2026

Study reveals why diffuse midline glioma develops in brain midline regions

Scientists at St. Jude Children's Research Hospital have shown that specific brain cells respond differently to the H3.3 K27M, a mutation in the histone H3.3 protein that drives many cases of diffuse midline glioma (DMG), depending on the cell's location in the developing brain.

27 Aug 2026

Faulty myelin-making brain cells may help drive cognitive decline with age

Researchers found that greater age-related cognitive decline was associated with more dysfunctional oligodendrocytes, reduced NRF2 expression, smaller myelinated axons, and abnormally thicker myelin in human white matter. Experiments in mice showed that deleting NRF2 specifically from oligodendrocytes reproduced key white matter abnormalities and reduced cognitive improvement over time, implicating this pathway in cognitive aging.

26 Aug 2026

New retina model reveals how CLN3-Batten disease damages vision

Researchers have developed a new way to study CLN3-Batten disease, a rare, inherited condition that causes early vision loss in children followed by progressive neurological decline.

26 Aug 2026

Maternal immune response to urinary tract infection may drive preterm birth risk

A new study published in Science Translational Medicine shows that the increased risk of preterm pregnancies associated with urinary tract infection (UTI), is linked to the body's immune response to the infection rather than to the bacteria themselves.

26 Aug 2026

Nanoparticles regenerate neurons and improve cognition in Alzheimer’s mice

The adult human brain has limited capacity to repair or regenerate neurons lost to Alzheimer's disease, the most common type of dementia.

26 Aug 2026

Tea, berries and dark chocolate featured in a diet linked to lower Parkinson’s risk

A prospective UK Biobank study of 123,655 adults found that a dietary pattern richer in flavonoid-containing foods was modestly associated with a lower incidence of hospital-recorded Parkinson’s disease. The association was strongest among those with the highest flavonoid diet scores, while exploratory proteomic and transcriptomic analyses pointed to possible neuroimmune and cell-adhesion pathways but did not establish causality or mechanism.

26 Aug 2026

Specific brain regions found more vulnerable to dementia with Lewy bodies

Dementia with Lewy bodies is one of the most common forms of dementia in older adults, after Alzheimer's disease.

26 Aug 2026

Molecular switch ERBB4 linked to broad range of Alzheimer's pathologies

What if amyloid plaques are not the whole story of Alzheimer's disease? New research suggests that a broad range of Alzheimer's pathologies may be orchestrated by a molecular switch called ERBB4 when it turns on in the wrong neurons.

26 Aug 2026

New review examines oral cancer drug delivery barriers and strategies

Delivering drugs directly to oral tumor sites remains challenging. A recent review involving researchers from Hasanuddin University examines barriers to local drug delivery and analyses strategies for targeting oral cancer lesions.

26 Aug 2026

Experimental vaccine protects against Zika virus through T cells alone

Zika virus has been spreading for decades, but it first grabbed worldwide headlines in 2016. That February, with an outbreak sweeping the Americas, the World Health Organization (WHO) declared the surge in Zika-linked birth defects a "public health emergency of international concern"-a designation which lasted until that November.

26 Aug 2026

Protecting the thymus may improve lung cancer treatment outcomes

Building on recent discoveries about the adult thymus, Mass General Brigham investigators used artificial intelligence to show that incidental radiation exposure to the thymus may influence outcomes in patients with lung cancer.

25 Aug 2026

New artificial lung mimics breathing and alveolar movement

Almost everyone has blown a soap bubble through a straw at least once. Inspired by this thin soap bubble film, an "artificial lung that breathes" like a real lung has been developed.

25 Aug 2026

Scientists found a distinct gut microbiome pattern in people with symptomatic diverticular disease

A multicenter Japanese study found that symptomatic uncomplicated diverticular disease (SUDD) was associated with reduced gut microbial diversity, increased abundance of the Ruminococcus gnavus group, and depletion of Coprococcus and other butyrate-producing bacteria. Predictive microbiome analysis also identified enrichment of pathways linked to exopolysaccharide biosynthesis and the cell cycle, although the observational design means these associations cannot establish causality.

25 Aug 2026

Study links thymus radiation to worse lung cancer outcomes

Until recently, the thymus was thought to be of little use beyond puberty, but new research has shown that radiation to the organ is associated with worse outcomes in patients being treated for non-small cell lung cancer (NSCLC).

25 Aug 2026

Ancient proteins revived to inspire new antimicrobial treatments

University of Oregon biologists have resurrected prehistoric proteins up to 160 million years old that carry natural antimicrobial properties.

25 Aug 2026

Scientists discover how neutrophils travel to infection sites without damaging healthy tissue

UMass Chan Medical School scientist Beth McCormick, PhD, and her team collaborated with researchers at the University of Bath to discover how neutrophils, the body's most abundant type of white blood cells, travel to infection sites without damaging healthy tissue.

25 Aug 2026

Gene removal makes engineered immune cells more effective against osteosarcoma

Scientists at St. Jude Children's Research Hospital have discovered that removing the gene for Regnase-1 from engineered immune cells makes them more effective at treating relapsed osteosarcoma.

25 Aug 2026

New molecular pathway explains why eye pressure rises at night

Glaucoma is an eye disease that causes progressive damage to the optic nerve, leading to loss of sight. One major risk factor is an increase in intraocular pressure (IOP), or the pressure inside the eye.

25 Aug 2026

New discovery helps identify colorectal cancer patients at risk for metastasis

Researchers from the University of Turku in Finland and Gustave Roussy Institute in France have discovered a molecular mechanism that regulates whether the cells of an aggressive colorectal cancer are conventional or inverted when they spread in the body.

25 Aug 2026