Chromosome 9 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 9, one copy inherited from each parent, form one of the pairs. Chromosome 9 is made up of about 140 million DNA building blocks (base pairs) and represents approximately 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 9 likely contains between 800 and 1,300 genes.

Genes on chromosome 9 are among the estimated 20,000 to 25,000 total genes in the human genome.

Scientists discover molecular defects associated with rare genetic disorder in children

Damien D'Amours and his team at the Ottawa Institute of Systems Biology needed three years to discover the molecular defects associated with the LIC Syndrome, a serious genetic disorder that affects young children and result in acute respiratory distress, immune deficiency and abnormal chromosomes.

22 Dec 2020

New understanding of physical properties of chromatin may show how genome is encoded and decoded

University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid?

20 Dec 2020

Study highlights how the sex differences in COVID-19 are linked to ACE2 protein

Female COVID-19 patients face less severe disease complications and a lower risk of dying than male patients thanks to hormones and chromosomes that contribute to a stronger immune response, according to new research from a University of Alberta-led team.

17 Dec 2020

BU researchers awarded $2.4 million NIH grant to study idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease that affects the tissue surrounding the air sacs in the lungs.

17 Dec 2020

Autoimmune condition biomarkers promote SARS-CoV-2 viral entry, study finds

Researchers have reported that the autoimmune PTPN2 risk variant rs1893217 promotes the expression of the SARS-CoV-2 receptor, ACE2, and thus promotes cellular entry, which is mediated by SARS-CoV-2 spike S protein.

16 Dec 2020

Neanderthal gene variant increases risk of severe COVID-19

Researchers in Germany have conducted a study showing that between 2 and 8% of people in Eurasia carry a genetic variant inherited from Neanderthals that significantly increases the risk of becoming critically ill with coronavirus disease 2019 (COVID-19).

15 Dec 2020

Study explores link between aging, obesity, and metabolic diseases

Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth).

14 Dec 2020

Study unlocks some muscle cell secrets

A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are.

11 Dec 2020

UCLA researchers identify gene that could help predict cervical cancer treatment response

UCLA researchers have identified a potential diagnostic marker that could help predict how likely someone with cervical cancer is to respond to the standard treatment of chemotherapy and radiation.

11 Dec 2020

IGC researchers receive three out of six European Research Council grants

Since the establishment of the European Research Council in 2008, the IGC has secured 17 of their competitive grants (7 Starting, 8 Consolidator and 2 Advanced).

10 Dec 2020

High error rates found in human egg cells

A new study has found that there is a high level of meiotic recombination failure in human immature egg cells (oocytes).

10 Dec 2020

Chemotherapy combined with blinatumomab increases survival for patients with Ph-negative B-ALL

A study led by The University of Texas MD Anderson Cancer Center showed that first-line treatment with a regimen of chemotherapy combined with the monoclonal antibody blinatumomab resulted in increased survival and achieved a high rate of measurable residual disease (MRD) negativity for patients who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative B-cell ALL (Ph-negative B-ALL).

7 Dec 2020

Genetic variants in pediatric cancer survivors of African ancestry increase risk of heart problems

Scientists at St. Jude Children's Research Hospital recently identified genetic variants in childhood cancer survivors of African ancestry that increase their risk of treatment-related heart problems.

7 Dec 2020

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

B-cell lymphoma and leukemias (BCL) are a diverse set of malignancies. While the genomic landscape of many BCL subtypes has been described, genomic ancestry has rarely been explored.

6 Dec 2020

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

A group of researchers developed a promising fix to CRISPR-Cas9's problem with unwanted genetic changes using a method that allows them to turn off gene-editing until it reaches key cell cycle phases where more accurate repairs are likely to happen.

4 Dec 2020

Study outlines a new role for pregnancy-associated plasma protein A in gestational diabetes

Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women.

30 Nov 2020

Chromosome 9 News and Research

Scientists discover molecular defects associated with rare genetic disorder in children

New understanding of physical properties of chromatin may show how genome is encoded and decoded

Study highlights how the sex differences in COVID-19 are linked to ACE2 protein

BU researchers awarded $2.4 million NIH grant to study idiopathic pulmonary fibrosis

Autoimmune condition biomarkers promote SARS-CoV-2 viral entry, study finds

Neanderthal gene variant increases risk of severe COVID-19

Study explores link between aging, obesity, and metabolic diseases

Study unlocks some muscle cell secrets

UCLA researchers identify gene that could help predict cervical cancer treatment response

IGC researchers receive three out of six European Research Council grants

High error rates found in human egg cells

Chemotherapy combined with blinatumomab increases survival for patients with Ph-negative B-ALL

Genetic variants in pediatric cancer survivors of African ancestry increase risk of heart problems

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

Study outlines a new role for pregnancy-associated plasma protein A in gestational diabetes

SARS-CoV-2 spike protein shows slow but stable evolution, study finds

Long-range regulation of tumor suppressor genes plays key role in cancer

Researchers develop recombinant SARS-CoV-2 model to aid vaccine and antiviral research

Research can bring new possibilities for earlier diagnosis, preventive treatment of dementia

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