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Researchers explore new combination approach to treat high-risk soft-tissue sarcomas

University of Maryland School of Medicine researchers are investigating a new approach to treat high-risk soft-tissue sarcomas by combining two immunotherapy drugs with radiation therapy to stimulate the immune system to destroy the main tumor as well as leftover microscopic cancer cells that may seed other tumors.

20 Sep 2017

New testing regime could speed up diagnosis and treatment of SCID in infants

Babies born with Severe Combined Immune Deficiency (SCID) syndrome are defenceless against bacterial and viral infections that would be virtually harmless to most healthy people. If untreated, SCID is often fatal within a baby's first year of life.

13 Sep 2017

FDA approves first cell-based gene therapy for use in the United States

The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases.

30 Aug 2017

UC San Diego researchers receive $18.2 million grant for B cell cancer clinical trial

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine today unanimously approved an $18.29 million grant to University of California San Diego School of Medicine researchers to fund a phase Ib/IIa clinical trial of a novel combination drug therapy for B-cell cancers.

26 Aug 2017

Study reveals strong prognostic indicators of survival in resected pancreatic cancer

A new study of patients who underwent curative surgical removal of a pancreatic ductal adenocarcinoma showed that two of the nine preoperative factors analyzed were strongly predictive of poor prognosis regardless of the tumor stage.

10 Aug 2017

Mice study reveals how natural killer cells in the placenta can cause miscarriages

Researchers at St. Michael's Hospital have identified how natural killer cells in the mouse placenta can cause a fetus to fail to grow in the womb or cause miscarriages.

9 Aug 2017

New study links hepatic inflammation to western diet

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males. Moreover, liver inflammation was most pronounced in Western diet-fed male mice that also lacked farnesoid x receptor (FXR), a bile acid receptor.

12 Jul 2017

Vitamin D supplements in pregnancy could help protect children against asthma

A new study published today in the Journal of Allergy and Clinical Immunology has found that taking Vitamin D supplements in pregnancy can positively modify the immune system of the newborn baby, which could help to protect against asthma and respiratory infections, a known risk factor for developing asthma in childhood.

26 May 2017

Merck presents data on investigational cladribine tablets in relapsing multiple sclerosis

Merck announced the presentation of new analyses of efficacy and safety data for investigational Cladribine Tablets in poster presentations at the Annual Meeting of the American Academy of Neurology (AAN), that took place April 22 – 28, 2017, in Boston, Massachusetts.

3 May 2017

Study finds higher rate of metal sensitization in women after joint replacement

Why are women at higher risk of complications after total hip or knee replacement surgery? An increased rate of hypersensitivity to the metals contained in joint implants might be a contributing factor, suggests a study in the April 19 issue of The Journal of Bone & Joint Surgery. The journal is published by Wolters Kluwer.

20 Apr 2017

Vitamin B supplements can mitigate impact of fine particle pollution on cardiovascular disease

B vitamins can mitigate the impact of fine particle pollution on cardiovascular disease, according to new research conducted at Columbia University's Mailman School of Public Health.

12 Apr 2017

One-shot vaccine passes key preclinical test in newborn monkey models

Newborns are highly vulnerable to infections and don't respond optimally to most vaccines because their young immune systems typically mount weak antibody responses.

24 Mar 2017

Research suggests way to reverse age-related and radiation-induced DNA damage

DNA repair is essential for cell vitality, cell survival and cancer prevention, yet cells' ability to patch up damaged DNA declines with age for reasons not fully understood.

24 Mar 2017

Salk scientists develop new way to find responders to lithium therapy

For roughly one-third of people diagnosed with bipolar disorder, lithium is a miracle drug, effectively treating both their mania and depression. But once someone is diagnosed, it can take up to a year to learn whether that person will be among the 30 percent who respond to lithium or the 70 percent who do not.

21 Mar 2017

Evolution of immuno-oncology

Immuno-oncology did not exist four years ago, it's a term coined by Dr. Axel Hoos, Head of the newly defined immuno-oncology department at GSK. He is also Senior Vice President Therapeutic Area (TA) and Head for Oncology R&D. Previously, it was referred to as cancer immunotherapy, but now it is called immuno-oncology (IO).

13 Mar 2017

Activated T-cells promote heart failure after heart attack

Chronic inflammation after a heart attack can promote heart failure and death. University of Alabama at Birmingham researchers have now shown that activated T-cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

28 Feb 2017

Lymphocyte News and Research

Researchers explore new combination approach to treat high-risk soft-tissue sarcomas

New testing regime could speed up diagnosis and treatment of SCID in infants

FDA approves first cell-based gene therapy for use in the United States

UC San Diego researchers receive $18.2 million grant for B cell cancer clinical trial

Study reveals strong prognostic indicators of survival in resected pancreatic cancer

Mice study reveals how natural killer cells in the placenta can cause miscarriages

New study links hepatic inflammation to western diet

Vitamin D supplements in pregnancy could help protect children against asthma

Merck presents data on investigational cladribine tablets in relapsing multiple sclerosis

Study finds higher rate of metal sensitization in women after joint replacement

Vitamin B supplements can mitigate impact of fine particle pollution on cardiovascular disease

One-shot vaccine passes key preclinical test in newborn monkey models

Research suggests way to reverse age-related and radiation-induced DNA damage

Salk scientists develop new way to find responders to lithium therapy

Evolution of immuno-oncology

Activated T-cells promote heart failure after heart attack

Research may show new ways to repress inflammation at outset

New immunotherapy active against mucosal melanoma and improves survival for bladder cancer patients

Overweight, obese children at increased risk of developing surgical site infectios, study shows

Study suggests new options for improving cancer immunotherapy

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