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Study uncovers mechanism to help explain how maternal stress causes idiopathic preterm birth

Preterm birth is a leading cause of infant deaths and illness in the U.S. -- yet its underlying molecular causes remain largely unclear. About 40 to 50% of preterm births, defined as births before 37 weeks of pregnancy, are estimated to be "idiopathic," meaning they arise from unexplained or spontaneous labor.

9 Mar 2021

CBD ameliorates cognitive function in experimental model of familial Alzheimer's

A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer's disease, and improves cognition in an experimental model of early onset familial Alzheimer's, investigators report.

9 Mar 2021

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

Among a large sample of COVID-19 patients, researchers found that a genetic variant – caused by an amino acid substitution from valine to methionine – is associated with a reduced chance of severe disease.

9 Mar 2021

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

A team of researchers in Spain has observed that, of those who have been vaccinated against SARS-CoV-2, higher titers of neutralizing antibodies for the B.1.1.7 variant (originating in the UK) were present in those who had previously been infected with the virus.

9 Mar 2021

Optimized SARS-CoV-2 vaccine candidate could be less reactogenic, say researchers

A new study, released as a preprint on the bioRxiv* server, reports an optimized coronavirus disease 2019 (COVID-19) vaccine candidate, which, claim the researchers, may be less likely to produce reactions like fevers. It may also have increased protective potential against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19.

9 Mar 2021

Rapid increase of UK SARS-CoV-2 variant found in sewage in England between October 2020 to January 2021

A new study confirms the utility of wastewater surveillance as an important new tool in this regard by showing the presence of the UK SARS-CoV-2 variant in wastewater samples from London early in November, with increasing frequency thereafter.

9 Mar 2021

New research project aims to treat patients with secondary brain damage

The Universities of Birmingham and Cambridge have launched a new research project aimed at discovering if selective P2X7 receptor blocker drugs can be repurposed to treat patients with secondary brain damage.

9 Mar 2021

Study suggests sewer rats immune to SARS-CoV-2

Although the researchers found that the rats tested negative for the virus, they say it is important to continue monitoring animals for the virus as it mutates, making previously resistant species susceptible to infection.

8 Mar 2021

Two doses of Pfizer-BioNTech SARS-CoV-2 vaccine induce humoral protection against U.K. and S.A. variants

Researchers at the Pitié Salpêtrière Hospital, Department of Virology, Paris, France determined that in BNT162b2-vaccinated participants who received two doses, their sera harbored at least a neutralizing titer against the three SARS-CoV-2 variants.

8 Mar 2021

Worse problems with SARS-CoV-2 variants may be on the way

Researchers at the Department of Integrative Biomedical Sciences, University of Cape Town, South Africa, found evidence of a significant change in the selective forces acting on immunologically important SARS-CoV-2 genes, such as N and S. These likely coincided with the emergence of the 501Y lineages.

8 Mar 2021

How do viruses evolve in bats?

Bats have played a crucial epidemiological role in the evolution of many viruses and house many coronaviruses. Until 2002, coronaviruses had been known to cause mild respiratory ailments in human beings. However, this notion changed in the same year when a bat-borne virus caused the severe acute respiratory syndrome (SARS) pandemic.

8 Mar 2021

Self-assembling nanoparticles an effective vaccine candidate for SARS-CoV-2

The currently developed vaccines against SARS-CoV-2 include the RBD in their immunogen. With a similar objective, a new study developed an RBD protein-based vaccine candidate against the SARS-CoV-2, using self-assembling Helicobacter pylori-bullfrog ferritin nanoparticles as an antigen delivery system. The study is published recently in the journal mBio (by the American Society of Microbiology).

8 Mar 2021

CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients

A new type of CAR T-cell therapy more than triples the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial with UT Southwestern as the lead enrolling site.

8 Mar 2021

Narrowing down on small molecular inhibitors of SARS-CoV-2 key protease

A recent methodological study by researchers from the University of Luxembourg shows that the combination of virtual screening approaches, molecular dynamics simulations and machine learning can substantially facilitate small molecule screening investigations targeted at key SARS-CoV-2 viral proteins.

8 Mar 2021

Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Researchers in the US recently infected a series of human lung and head/neck cancer cell lines with SARS-CoV-2 that expressed varying levels of ACE2 and the TMPRSS2 protease to reassess their role in viral entrance.

8 Mar 2021

Researchers present fragment-based computational design of antibodies that target structured epitopes

A new study describes a novel fragment-based method to design antibody complementarity determining region (CDR) loops.

8 Mar 2021

Impairments in immune response contribute to severe COVID-19

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

8 Mar 2021

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

A new paper in the journal Life presents an early review of the viral factors involved in initiating and effecting apoptosis within infected cells.

8 Mar 2021

Using decision theory for precise choice of breast cancer treatment

The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for oestrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with a certain error rate, which can be reduced by adding genomic data.

8 Mar 2021

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP—the standard treatment regimen.

8 Mar 2021

Receptor News and Research

Study uncovers mechanism to help explain how maternal stress causes idiopathic preterm birth

CBD ameliorates cognitive function in experimental model of familial Alzheimer's

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

Optimized SARS-CoV-2 vaccine candidate could be less reactogenic, say researchers

Rapid increase of UK SARS-CoV-2 variant found in sewage in England between October 2020 to January 2021

New research project aims to treat patients with secondary brain damage

Study suggests sewer rats immune to SARS-CoV-2

Two doses of Pfizer-BioNTech SARS-CoV-2 vaccine induce humoral protection against U.K. and S.A. variants

Worse problems with SARS-CoV-2 variants may be on the way

How do viruses evolve in bats?

Self-assembling nanoparticles an effective vaccine candidate for SARS-CoV-2

CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients

Narrowing down on small molecular inhibitors of SARS-CoV-2 key protease

Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Researchers present fragment-based computational design of antibodies that target structured epitopes

Impairments in immune response contribute to severe COVID-19

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

Using decision theory for precise choice of breast cancer treatment

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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