Immune System News and Research

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Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations

6 Oct 2020

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system.

6 Oct 2020

Study shows why antiretroviral therapy does not work in certain HIV patients

Increasingly, UPMC's chief of infectious diseases - a well-regarded expert in HIV/AIDS - is contacted by a perplexed physician describing a patient with HIV who insists they are adhering to the daily medication regimen meant to keep the virus in check, but testing says otherwise.

6 Oct 2020

New findings could improve investigation of T cell response to COVID-19

Researchers in the United States have made an important discovery about the processing and presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral peptides that provides a better understanding of the immune response to coronavirus disease 2019 (COVID-19) and may help facilitate the design of improved vaccines.

5 Oct 2020

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Preliminary results from two independent, phase II clinical trials investigating a new PD-1 (programmed cell death protein 1)-based immune therapy for metastatic cervical cancer suggest potential new treatment options for a disease that currently has limited effective options and disproportionately impacts younger women.

5 Oct 2020

Advanced model reveals dynamic motions of SARS-COV-2 spike-shielding glycans

A recent paper published on the preprint server bioRxiv in September 2020 discusses the dynamic interactions of the spike protein glycan shield, which may be of great value in developing therapeutic compounds to fight severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Oct 2020

Ludwig study uncovers a nutritional approach to improve cancer immunotherapy

A Ludwig Cancer Research study has uncovered a mechanism by which the tumor's harsh internal environment sabotages T lymphocytes, leading cellular agents of the anticancer immune response.

5 Oct 2020

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

A team of researchers in the Perelman School of Medicine at the University of Pennsylvania, Case Western Reserve University, Cleveland Clinic, and Cedars-Sinai Medical Center, were recently awarded a $3.2 million grant from the National Institutes of Health to enhance research for improving heart transplant outcomes for patients.

5 Oct 2020

Applying the power of AI to improve heart-transplant outcomes

The team of biomedical researchers at the Center for Computational Imaging and Personalized Diagnostics has tackled various aspects of lung cancer, breast cancer, colon cancer and more since the center was launched at Case Western Reserve University in 2012 by bioengineering pioneer Anant Madabhushi.

5 Oct 2020

Supporting Coronavirus Research with Liquid Chromatography

The RNA in viruses such as SARS-CoV-2 are an ideal research target. RNA purification with liquid chromatography is essential in the fight against SARS-CoV-2.

From KNAUER Wissenschaftliche Geräte GmbH 5 Oct 2020

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Using ELISpot and proliferation assays, researchers show strong responses in SARS-CoV-2 infected patients, but not so much in negative samples. However, there may be cross-reactive T cell responses from other human coronaviruses.

5 Oct 2020

Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Patients with hematological malignancy (PHM), also infected with COVID-19, were investigated for SARS-CoV-2 antibody responses while undergoing systemic anti-cancer therapy. While no obvious correlation is found between the serological results and the hematological diagnosis and the treatment, the immune response is similar to the severity of COVID-19 infection observed in the general population.

4 Oct 2020

Study reveals how immune cells sacrifice themselves to help fight off infections

Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection.

1 Oct 2020

Scientists map genetic networks that control the biology of regulatory T cells

Unlike most T cells, which launch immune responses against foreign molecules, regulatory T cells are the peacekeepers of the human immune system, damping down inflammatory reactions when they're not needed.

1 Oct 2020

New multiplexed test with a low-cost sensor may enable at-home COVID diagnosis

One feature of the COVID-19 virus that makes it so difficult to contain is that it can be easily spread to others by a person who has yet to show any signs of infection.

1 Oct 2020

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Social isolation worsens the effects of Alzheimer's disease, study shows

A study in mice conducted by the UAB shows that social isolation worsens the effects of Alzheimer's disease, with hyperactivity levels reaching up to twice as much as in the pathology itself.

1 Oct 2020

Immunotherapy drug improves survival over standard chemotherapy for lung cancer patients

The immunotherapy drug atezolizumab improves survival over standard chemotherapy for many patients with newly diagnosed non-small cell lung cancer (NSCLC), according to a new study led by Yale Cancer Center (YCC) researchers.

1 Oct 2020

Researchers identify a promising method to treat multiple sclerosis

Seema Tiwari-Woodruff, a professor of biomedical sciences in the School of Medicine at the University of California, Riverside, and her colleagues have received a grant of $373,000 from the National Multiple Sclerosis Society for a project in which her lab will select the five best candidate compounds to speed up nerve impulses, a promising new avenue to treat multiple sclerosis.

1 Oct 2020

Researchers use single-cell sequencing to identify cell types that occur in pancreatic tumors

Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and Innovation Institute, an international team of researchers have described in detail the individual cells that comprise the pancreatic cancer microenvironment, a critical step in devising new treatment options for patients with this aggressive and difficult-to-treat disease.

1 Oct 2020

Immune System News and Research

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Study shows why antiretroviral therapy does not work in certain HIV patients

New findings could improve investigation of T cell response to COVID-19

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Advanced model reveals dynamic motions of SARS-COV-2 spike-shielding glycans

Ludwig study uncovers a nutritional approach to improve cancer immunotherapy

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

Applying the power of AI to improve heart-transplant outcomes

Supporting Coronavirus Research with Liquid Chromatography

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Study reveals how immune cells sacrifice themselves to help fight off infections

Scientists map genetic networks that control the biology of regulatory T cells

New multiplexed test with a low-cost sensor may enable at-home COVID diagnosis

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

Social isolation worsens the effects of Alzheimer's disease, study shows

Immunotherapy drug improves survival over standard chemotherapy for lung cancer patients

Researchers identify a promising method to treat multiple sclerosis

Researchers use single-cell sequencing to identify cell types that occur in pancreatic tumors

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