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New portable device can quickly find markers of sepsis from single drop of blood

A new portable device can quickly find markers of deadly, unpredictable sepsis infection from a single drop of blood.

3 Jul 2017

Proteins impeding antitumor immunity could be 'Achilles heel' of some cancers

By comparing variations in protein expression in tumor samples from a single melanoma patient, researchers from the Johns Hopkins Bloomberg~Kimmel Institute and the Memorial Sloan-Kettering Cancer Center say their findings have the potential to reveal some of the mechanisms underlying response or resistance to immunotherapy drugs.

28 Jun 2017

Study finds link between upper GI infections and protein implicated in Parkinson’s disease

Acute and chronic infections in a person's upper gastrointestinal tract appear to be linked to Parkinson's disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions.

28 Jun 2017

Wayne State awarded NIH grant to identify new therapeutic targets for bacterial keratitis

Wayne State University recently received a five-year, $1.925 million grant from the National Eye Institute of the National Institutes of Health to test the role of microRNAs (miRNAs) - a newly recognized level of gene expression regulation - in bacterial keratitis – an infection of the cornea caused by bacteria - as well as to identify new therapeutic targets and alternative treatment strategies.

15 Jun 2017

Hidden immune cells play key role in driving primary graft dysfunction

Northwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation.

15 Jun 2017

New study suggests potential new therapeutic approach to septic shock recovery

A new study published online in the Journal of Leukocyte Biology suggests a new approach to treating patients with sepsis, one of the most frequent causes of morbidity and mortality in intensive care units.

1 Jun 2017

LMU researchers show how genetic variant in people of African ancestry modulates immune cells

A genetic variant that is particularly prevalent in people of African ancestry confers protection against malaria. LMU researchers have now shown how it modulates the properties of white blood cells that play a major role in immune defenses and inflammation.

1 Jun 2017

Pulmonary thrombosis-on-a-chip enables unprecedented study of blood responses to organ-level injury

The average human pair of lungs is permeated by a network of about 164 feet of blood vessels (roughly the width of a football field), including microscopic blood capillaries, which facilitate the diffusion of oxygen into the bloodstream in exchange for carbon dioxide.

23 May 2017

WSU scientists develop new approach to deliver therapeutics to tumors

For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues.

16 May 2017

Researchers discover that microRNA can prevent excessive intestinal inflammation

An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the intestine.

9 May 2017

Study: Use of white blood cell boosting drugs found to be safe during chemo-radiotherapy of lung cancer

A late breaking subanalysis of the phase III CONVERT trial presented at the European Lung Cancer Conference shows that white blood cell boosting drugs are safe during concurrent chemo-radiotherapy of small cell lung cancer (SCLC).

5 May 2017

Impaired effects of insulin can increase cancer risk, shows study

Over the decades, scientists have repeatedly shown that patients with increased levels of the hormone insulin in their blood can experience increased risks of cancer. Surprisingly, however, Joslin Diabetes Center researchers now have discovered that impaired effects of insulin also can boost these risks.

3 May 2017

Researchers aim to test asthma drug for treating patients with heart disease

Researchers at Guy's and St Thomas' NHS Foundation Trust have launched an innovative new trial which aims to improve the recovery of patients with serious heart conditions.

27 Apr 2017

Air pollution may directly affect biology of upper airways to cause chronic sinus problems

Although human population studies have linked air pollution to chronic inflammation of nasal and sinus tissues, direct biological and molecular evidence for cause and effect has been scant.

18 Apr 2017

Study shows how early administration of old drug reduces damage during heart attack

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have discovered a new mechanism of action of metoprolol, a drug that can reduce the damage produced during a heart attack if administered early.

18 Apr 2017

Research finds diagnostic tests to be less accurate for children with impaired kidney function

Breaking research published today in AACC's Journal of Applied Laboratory Medicine reveals that a number of diagnostic tests are less accurate when performed in pediatric patients with impaired kidney function.

17 Apr 2017

TSRI scientists develop easy method for synthesizing compounds with potential to treat lung disorders

Chemists at The Scripps Research Institute have developed a broad and strikingly easy method for synthesizing a class of molecules that have demonstrated value as pharmaceuticals.

17 Apr 2017

Research unravels how cytokines prevent multi-organ damage during parasitic infection

Cytokines are proteins secreted by several types of immune cells in response to infection, inflammation, or injury. Interleukin-17 (IL-17) is one such cytokine that causes inflammation, by controlling the production of other cytokines and mobilizing a type of white blood cell (neutrophil) that fights infections.

3 Apr 2017

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.

25 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017