Small Molecules News and Research

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Scientists develop molecules that can remodel gut bacteria to a healthier state

Scientists at Scripps Research have developed molecules that can remodel the bacterial population of intestines to a healthier state and they have shown--through experiments in mice--that this reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis.

16 Jun 2020

Millimeter-thick cell-laden hydrogel fiber helps control blood glucose in diabetic mice

Type 1 diabetes mellitus results from an irreversible autoimmune destruction of insulin-producing pancreatic β-cells requiring life-long substitution of insulin.

15 Jun 2020

Glycans "lock and load" the SARS-CoV-2 spike protein for infection

A new study by scientists from the University of California San Diego, USA and Maynooth University, Ireland and published on the preprint server bioRxiv* in June 2020 reports preliminary results showing that the spike protein of the SARS-CoV-2, as well as its glycan coat, has “hitherto unseen functional and structural” properties. These may be useful in designing novel therapeutics to target this molecule.

14 Jun 2020

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

A new study by Italian researchers and published online on the preprint server bioRxiv* in June 2020 reports the ability of several existing steroidal drugs to reduce the binding of the SARS-CoV-2 to the ACE2 receptor. This could help define newer strategies using viral entry blockers to reduce viral load.

14 Jun 2020

Drug-like molecules offer a promising treatment for COVID-19

A team of researchers at the University of Georgia has successfully demonstrated that a set of drug-like small molecules can block the activity of a key SARS-CoV-2 protein - providing a promising path for new COVID-19 therapeutics.

12 Jun 2020

Turning autoimmunity drugs into anti-cancer treatments

Professor Mark Cragg speaks to News-Medical about his research which involves turning autoimmunity drugs into anti-cancer treatments.

11 Jun 2020

Virginia Tech researcher develops new ‘fat burning’ molecule with potential to treat obesity

Obesity affects more than 40 percent of adults in the United States and 13 percent of the global population.

8 Jun 2020

George Mason researcher examining the use of Brilacidin for treatment of coronavirus infections

Aarthi Narayanan, Assistant Professor, National Center for Biodefense and Infectious Diseases, received $35,000 from Innovation Pharmaceuticals, Inc., for a project in which she is examining the use of Brilacidin for the treatment of coronavirus infections.

5 Jun 2020

Creating hair-bearing human skin becomes a reality

For more than 40 years, scientists and commercial companies have been recreating human skin in laboratories around the world. Yet all of these products lack important aspects of normal skin--hair, nerves, and fat.

5 Jun 2020

Study: MafB protein may protect against renal failure

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome, a type of kidney disease that is accompanied by massive urinary protein loss and that may progress to end-stage renal disease.

5 Jun 2020

Natural molecules that stimulate dopamine production may help reverse Parkinson's disease

Investigators have identified two molecules naturally produced by the body that stimulate the production of dopamine, the molecule that is in short supply in the brains of patients with Parkinson's disease.

4 Jun 2020

New device shows cigarette alternatives may be more hazardous than revealed by manufacturer testing

A more sensitive technique shows cigarette alternatives may be more hazardous than manufacturer testing had found.

4 Jun 2020

Small protein has a large impact on bacterial gene regulation

Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding protein ProQ is involved in the activation of more than 250 bacterial genes.

4 Jun 2020

New platform can speed up the development of novel antibiotics

Harmful bacteria react less and less to common antibiotics. The infections they cause are therefore increasingly deadly.

4 Jun 2020

Bruker introduces breakthrough MALDI-2 source on timsTOF fleX, and further innovations in CCS-enabled 4D proteomics on timsTOF

At the virtual ASMS 2020 Reboot conference, Bruker Corporation today announces a major advance in matrix-assisted laser desorption ionization (MALDI) with the launch of the world’s first commercial MALDI-2 post-ionization (PI) source, which is now available as an option on the timsTOF fleXTM ESI/MALDI mass spectrometer.

From Bruker Daltonics 3 Jun 2020

Small Molecules News and Research

Scientists develop molecules that can remodel gut bacteria to a healthier state

Millimeter-thick cell-laden hydrogel fiber helps control blood glucose in diabetic mice

Glycans "lock and load" the SARS-CoV-2 spike protein for infection

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

Drug-like molecules offer a promising treatment for COVID-19

Turning autoimmunity drugs into anti-cancer treatments

Virginia Tech researcher develops new ‘fat burning’ molecule with potential to treat obesity

George Mason researcher examining the use of Brilacidin for treatment of coronavirus infections

Creating hair-bearing human skin becomes a reality

Study: MafB protein may protect against renal failure

Natural molecules that stimulate dopamine production may help reverse Parkinson's disease

New device shows cigarette alternatives may be more hazardous than revealed by manufacturer testing

Small protein has a large impact on bacterial gene regulation

New platform can speed up the development of novel antibiotics

Bruker introduces breakthrough MALDI-2 source on timsTOF fleX, and further innovations in CCS-enabled 4D proteomics on timsTOF

New high-resolution mass spectrometer expands the proven Thermo Scientific Orbitrap platform

UZH researchers develop new X-ray contrast agent for high-resolution vascular imaging

Cancer biologists identify important drivers of tumor resistance

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

University of Greenwich develops compounds that can fight COVID-19 killer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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