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Study: High levels of circ E7 is a positive prognostic marker in anal squamous cell carcinoma

High levels of circ E7 by quantitative RT-PCR predicted improved overall survival in ASCC and analysis of The Cancer Genome Atlas sequencing from HPV-positive head and neck cancer and cervical cancer suggested high circ E7 marked improved survival in 875 subjects.

17 Oct 2019

Study reveals new and surprising function of adenine nucleotide translocator

Mutations in the gene that encodes a protein called adenine nucleotide translocator (ANT) cause a variety of conditions, such as heart disease and weakness of the eye muscles, but the underlying mechanism of how these mutations trigger disease has been unclear.

16 Oct 2019

Spectrum Health, MSU researchers aim to find new or better treatments for "orphan diseases"

The National Institutes of Health has awarded a Michigan State University researcher a $2.1 million, five-year grant to search vast databases of existing drugs.

16 Oct 2019

Epigenetic changes can lead to development of GISTs, other cancers

Most cases of gastrointestinal stromal tumor (GIST), a type of soft-tissue cancer (sarcoma), are caused by mutations in genes that can be effectively targeted with drugs that inhibit the activity of rogue cancer-promoting enzymes.

16 Oct 2019

Scientists discover novel virus that may shed light on viral evolution

Viruses are non-living creatures, consisting of genetic material encased in a protein coat. Once the virus infects a living organism, it can replicate itself and continue on. But what happens if a virus lacks the proper tools to infect an organism? How can it propagate?

16 Oct 2019

Scientists discover how malaria switched host from African gorillas to humans

Researchers have revealed the series of events that probably led to the world’s deadliest form of malaria being able to jump from ancient great apes to humans.

16 Oct 2019

BioStreamline: Streamlining the development of next generation biotherapeutics

A collaboration to streamline the development of cost-effective next generation biotherapeutics will host a dissemination event at CPI.

From Fluidic Sciences and Sphere Bio 16 Oct 2019

Oxford Genetics and Sphere Fluidics announce a multi-partner collaboration

Oxford Genetics and Sphere Fluidics announce a multi-partner collaboration to expedite the development of automated microfluidic systems.

From Fluidic Sciences and Sphere Bio 16 Oct 2019

NIH awards new contract to integrate pathogen and vector genomics database

A team led by scientists at the University of Pennsylvania and University of Georgia provides thousands of researchers around the world with access to the Eukaryotic Pathogen Genomics Database (EuPathDB.org), a collection of resources for analyzing large-scale datasets associated with microbial pathogens.

16 Oct 2019

Researcher explores biological processes that cause fertility problems in humans

With significant funding from the National Institutes of Health (NIH), a researcher at The University of Texas at Arlington is investigating fundamental biological processes that lead to fertility problems in humans.

16 Oct 2019

Study: Genetic differences in the immune system shape bacteria that colonize the digestive system

Genetic differences in the immune system shape the collections of bacteria that colonize the digestive system, according to new research by scientists at the University of Chicago.

16 Oct 2019

Koalas protect their germline cells against retroviral attack

In a new study published in the journal Cell, scientists have found that koala DNA is protected against attack by retroviruses by a special type of immune response, which distinguishes foreign DNA from the host genome and destroys it before it can proliferate. This finding could help us understand both how koalas survive these infections, and the mechanics of adaptive gene change.

15 Oct 2019

New molecular "clock" could help monitor life-altering development disorders in children

Scientists have developed a molecular "clock" that could reshape how pediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders.

15 Oct 2019

Researchers reveal mechanism involved in altering DNA methylation in cancer

Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional team led by researchers at Baylor College of Medicine has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.

15 Oct 2019

Finnish study offers new information about molecular mechanisms of Alzheimer's disease

Researchers have discovered new changes in blood samples associated with Alzheimer's disease. A new international study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy.

15 Oct 2019

Advances in translational genetics unlocked by Bio-Rad technologies to be presented at ASHG 2019

Scientists will present 24 abstracts and three talks, highlighting research driven in part by Bio-Rad Laboratories' Droplet Digital PCR and single-cell ATAC-Seq (scATAC-Seq) technologies, at the 2019 American Society of Human Genetics Annual Meeting in Houston, October 15-19.

15 Oct 2019

Study suggesting that CRISPR babies are likely to die early has been retracted

A research paper that sparked concerns about the lifespan of China's first gene-edited babies has been retracted due to technical errors.

15 Oct 2019

Risk of genetic seizure disorder: new scoring system

A Cleveland Clinic-led initiative has come up with a new risk scoring system for epileptic or seizure disorders of genetic origin. The researchers summed up the risks for a very large number of genes weakly implicated in some common forms of epilepsy, to create a polygenic risk score.

14 Oct 2019

The language of metabolites can be decoded with new genome technology

A team of microbiologists and genomicists has invented a genetic engineering tool that advances the study of secondary metabolites, which will expand our understanding of how microbes evolve.

14 Oct 2019

Custom-made oligonucleotide therapy for girl with fatal Batten disease

Sufferers of fatal Batten disease have been given new hope as scientists develop a custom-made oligonucleotide therapy for a young girl.

14 Oct 2019

Genome News and Research

Study: High levels of circ E7 is a positive prognostic marker in anal squamous cell carcinoma

Study reveals new and surprising function of adenine nucleotide translocator

Spectrum Health, MSU researchers aim to find new or better treatments for "orphan diseases"

Epigenetic changes can lead to development of GISTs, other cancers

Scientists discover novel virus that may shed light on viral evolution

Scientists discover how malaria switched host from African gorillas to humans

BioStreamline: Streamlining the development of next generation biotherapeutics

Oxford Genetics and Sphere Fluidics announce a multi-partner collaboration

NIH awards new contract to integrate pathogen and vector genomics database

Researcher explores biological processes that cause fertility problems in humans

Study: Genetic differences in the immune system shape bacteria that colonize the digestive system

Koalas protect their germline cells against retroviral attack

New molecular "clock" could help monitor life-altering development disorders in children

Researchers reveal mechanism involved in altering DNA methylation in cancer

Finnish study offers new information about molecular mechanisms of Alzheimer's disease

Advances in translational genetics unlocked by Bio-Rad technologies to be presented at ASHG 2019

Study suggesting that CRISPR babies are likely to die early has been retracted

Risk of genetic seizure disorder: new scoring system

The language of metabolites can be decoded with new genome technology

Custom-made oligonucleotide therapy for girl with fatal Batten disease

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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