Enzyme News and Research

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High levels of natural immune suppressor in leukemia patients linked to poor survival

Patients diagnosed with the most common form of leukemia who also have high levels of an enzyme known to suppress the immune system are most likely to die early, researchers say.

27 Nov 2017

Chromatrap introduces easy-to-use range of DNA kits for molecular biology applications

Chromatrap, a leading developer of cutting-edge life science products, has launched an affordable, easy-to-use range of DNA kits for routine molecular biology applications.

From Chromatrap® - Porvair Sciences Ltd 23 Nov 2017

Drug could be repurposed to help end transplant rejection

A diabetes drug currently undergoing development could be repurposed to help end transplant rejection, without the side-effects of current immunosuppressive drugs, according to new research by Queen Mary University of London.

21 Nov 2017

Scientists develop novel technology that uses CRISPR to map genetic mutations

A team of scientists led by Virginia Commonwealth University physicist Jason Reed, Ph.D., have developed new nanomapping technology that could transform the way disease-causing genetic mutations are diagnosed and discovered.

21 Nov 2017

Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’

The destructive force of UV radiation on DNA molecules is only fully visible, when repair mechanisms fail: patients with the rare genetic disease Xeroderma pigmentosum - also known as 'Moon children' - develop inflammations upon exposure to only small amounts of sunlight, rough-surfaced growths and eventually skin cancer occurs often in early age.

21 Nov 2017

Gene editing within a living person for the first time

Genetic editing has been performed in the laboratory until now. Living cells within Petri-dishes have been put under the microscope while gene editing tools such as CRISPR were used to cut, nick and replace parts of the DNA or genome that is defective with bits of DNA that is correct in its sequence. Now doctors in California have attempted to edit cells within a living person.

19 Nov 2017

Mount Sinai researchers identify new therapeutic target for ER+ breast cancer

Researchers at the Icahn School of Medicine at Mount Sinai have identified a protein that can be targeted to suppress growth of a common type of breast cancer known as "estrogen receptor positive" (ER+), including ER+ cancers that are resistant to standard treatments.

17 Nov 2017

Researchers find way to switch tumor cells between 2D and 3D morphology

Paving the way for testing experimental drugs in more realistic environments, scientists at the National Institute of Standards and Technology have discovered how to make tiny colonies of cells grow in useful new ways inside petri dishes.

17 Nov 2017

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

In the fight against brain damage caused by stroke, researchers have turned to an unlikely source of inspiration: hibernating ground squirrels.

17 Nov 2017

Penn researchers single out bacterial enzyme behind gut microbiome imbalance linked to Crohn’s disease

Penn Medicine researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn's disease.

16 Nov 2017

CRISPR shows potential to reduce diseases spread by mosquitoes

Research at the University of California, Riverside, have shown that it is possible for transgenic mosquitos to stably express the Cas9 enzyme in their germline. Cas9 addition will allow the utilization of the CRISPR gene editing tool to carry out efficient and highly targeted changes to the DNA of the mosquitoes.

16 Nov 2017

FDA approves drug to treat pediatric, adult patients with rare Sly syndrome

The U.S. Food and Drug Administration today approved Mepsevii (vestronidase alfa-vjbk) to treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome. MPS VII is an extremely rare, progressive condition that affects most tissues and organs.

15 Nov 2017

Study identifies molecular pathway critical to development of fibrosis

A study led by investigators at Massachusetts General Hospital and University Health Network in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis - scarring and excessive tissue deposition that result from abnormal healing responses and can compromise the function of vital organs.

15 Nov 2017

Compact broadband NIRS system offers safe, non-invasive way to monitor newborn brain function

Multimodal-Spectroscopy research team in the Biomedical Optics Research Laboratory at the Medical Physics and Biomedical Engineering department at University College London led by Dr IliasTachtsidis has designed CYRIL, a compact broadband near-infrared spectroscopy(NIRS) system, to monitor brain tissue physiology non-invasively in newborn babies.

15 Nov 2017

Nanoparticles carrying CRISPR gene editing tools for genetic modifications

Researchers from MIT have now developed nanoparticles that could carry CRISPR genetic editing systems deep within the cells and perform their functions on the DNA. The paper was published in the November issue of Nature Biotechnology.

14 Nov 2017

UCR researchers develop transgenic mosquitoes to help reduce spread of infectious diseases

Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to the mosquitoes' DNA.

14 Nov 2017

Scientists identify critical player in Alzheimer's disease pathogenesis

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check.

14 Nov 2017

Recommendations to prevent heart failure hospitalizations

Heart failure (HF) affects approximately 5.7 million adults in the United States according to the Centers for Disease Control and Prevention. If not properly managed, HF can lead to frequent hospitalizations.

10 Nov 2017

Study identifies promising treatment to reduce brain injury in babies

Research-clinicians at Children's National Health System led the first study to identify a promising treatment to reduce or prevent brain injury in newborns who have suffered hypoxia-ischemia, a serious complication in which restricted blood flow deprives the brain of oxygen.

10 Nov 2017

Researchers show how rhythm of DNA replication can be manipulated to kill cancer cells

Human cells divide and create new cells throughout life. In this process, a steady – even rhythmic – supply of DNA building blocks is needed to create new DNA. Now researchers from the University of Copenhagen are the first to show exactly how human cells regulate this process so it does not fail and cause illness.

10 Nov 2017

Enzyme News and Research

High levels of natural immune suppressor in leukemia patients linked to poor survival

Chromatrap introduces easy-to-use range of DNA kits for molecular biology applications

Drug could be repurposed to help end transplant rejection

Scientists develop novel technology that uses CRISPR to map genetic mutations

Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’

Gene editing within a living person for the first time

Mount Sinai researchers identify new therapeutic target for ER+ breast cancer

Researchers find way to switch tumor cells between 2D and 3D morphology

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

Penn researchers single out bacterial enzyme behind gut microbiome imbalance linked to Crohn’s disease

CRISPR shows potential to reduce diseases spread by mosquitoes

FDA approves drug to treat pediatric, adult patients with rare Sly syndrome

Study identifies molecular pathway critical to development of fibrosis

Compact broadband NIRS system offers safe, non-invasive way to monitor newborn brain function

Nanoparticles carrying CRISPR gene editing tools for genetic modifications

UCR researchers develop transgenic mosquitoes to help reduce spread of infectious diseases

Scientists identify critical player in Alzheimer's disease pathogenesis

Recommendations to prevent heart failure hospitalizations

Study identifies promising treatment to reduce brain injury in babies

Researchers show how rhythm of DNA replication can be manipulated to kill cancer cells

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