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Study on cell stress response may hold promise for treating inflammation-related disorders

Stress – defined broadly – can have a profoundly deleterious effect on the human body. Even individual cells have their own way of dealing with environmental strains such as ultraviolet radiation from the sun or germs.

4 Oct 2017

Novel agents appear to halt growth and progression of Ewing sarcoma

When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress.

4 Oct 2017

Researchers provide new insights into how calcium signals trigger wound healing

In a sharp and pointy world, wound healing is a critical and marvelous process. Despite a tremendous amount of scientific study, many outstanding mysteries still surround the way in which cells in living tissue respond to and repair physical damage.

3 Oct 2017

Scientists unravel mechanism that links gut bacteria to hypertension

One in three American adults suffers from high blood pressure, or hypertension. The disease can be passed down in families, and certain lifestyle factors such as smoking, high-sodium diets, and stress can increase the risk.

3 Oct 2017

Researchers discover circadian clock at work in our muscles

Biological clocks are ticking everywhere throughout our body. They trigger the release of the hormone melatonin during sleep, favour the secretion of digestive enzymes at lunchtime or keep us awake at the busiest moments of the day.

3 Oct 2017

Study sheds light on the mechanism of lung damage in premature babies

The lungs are one of the last organs to undergo full maturation in a baby's body. Children that are born very prematurely do not have fully developed lungs, and are therefore more susceptible to associated complications.

30 Sep 2017

TSRI scientists developed new strategy to discover novel anti-cancer therapies

Scientists at The Scripps Research Institute (TSRI) have developed and demonstrated a promising new strategy for the discovery of novel anti-cancer therapies.

30 Sep 2017

Novartis partners with UC Berkeley to pursue 'undruggable' disease targets

Novartis has joined forces with researchers from the University of California, Berkeley, to develop new technologies for the discovery of next-generation therapeutics, pursuing the vast number of disease targets in cancer and other illnesses that have eluded traditional small-molecule compounds and are considered "undruggable."

28 Sep 2017

Gene editing technique helps uncover potential new drug targets for KRAS-driven cancers

Cancers driven by mutations in the KRAS gene are among the most deadly. For decades, researchers have tried unsuccessfully to directly target mutant KRAS proteins as a means to treat tumors.

28 Sep 2017

High-speed method generates mini-protein binders with potential to become new class of drugs

Scientists have created a high-speed method to generate thousands of different, small, stable proteins from scratch that can be custom-designed to bind to specific therapeutic targets.

27 Sep 2017

Huddersfield cancer scientists aim to develop new treatments for young people

CANCER researchers at the University of Huddersfield aim to develop new treatments specifically for young people and they will be aided in their quest by financial support from a locally-based charity.

27 Sep 2017

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Two drugs, already approved for safe use in people, may be able to improve therapy for chronic myeloid leukemia (CML), a blood cancer that affects myeloid cells, according to results from a University of Iowa study in mice.

26 Sep 2017

Drug targeting approach could lead to improved therapies for immune-related diseases

A new technique that targets drugs to specific cells could lead to improved therapies for diseases caused by an overactive immune response.

25 Sep 2017

New MRI contrast agent differentiates between aggressive and slow-growing breast cancers

A new magnetic resonance imaging (MRI) contrast agent being tested by researchers at Case Western Reserve University not only pinpoints breast cancers at early stages but differentiates between aggressive and slow-growing types.

25 Sep 2017

'Labyrinth' chip may be new way to monitor cancer patients in clinical trials

Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. It is already in use in a breast cancer clinical trial.

21 Sep 2017

Small-molecule immunotherapeutics could steer immune defense against fungal pathogens

Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now report in the journal Angewandte Chemie that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action.

21 Sep 2017

Researchers design novel small antibody fragment with improved crystallizability

Antibodies are a powerful weapon system in defending our body against invaders such as bacteria and viruses. Each antibody consists of four polypeptide chains: two heavy chains and two light chains joined to form a Y-shaped molecule.

21 Sep 2017

Study opens new door to potential treatments for highly lethal brain tumors

New research conducted in mice provides evidence that highly lethal brain tumors, called high-grade gliomas, stop growing when deprived of a specific molecule naturally produced when brain cells fire.

21 Sep 2017

MIT engineers design more effective synthetic mRNA delivery system

By delivering strands of genetic material known as messenger RNA into cells, researchers can induce the cells to produce any protein encoded by the mRNA. This technique holds great potential for administering vaccines or treating diseases such as cancer, but achieving efficient delivery of mRNA has proven challenging.

21 Sep 2017

Researchers explore new combination approach to treat high-risk soft-tissue sarcomas

University of Maryland School of Medicine researchers are investigating a new approach to treat high-risk soft-tissue sarcomas by combining two immunotherapy drugs with radiation therapy to stimulate the immune system to destroy the main tumor as well as leftover microscopic cancer cells that may seed other tumors.

20 Sep 2017

Molecule News and Research

Study on cell stress response may hold promise for treating inflammation-related disorders

Novel agents appear to halt growth and progression of Ewing sarcoma

Researchers provide new insights into how calcium signals trigger wound healing

Scientists unravel mechanism that links gut bacteria to hypertension

Researchers discover circadian clock at work in our muscles

Study sheds light on the mechanism of lung damage in premature babies

TSRI scientists developed new strategy to discover novel anti-cancer therapies

Novartis partners with UC Berkeley to pursue 'undruggable' disease targets

Gene editing technique helps uncover potential new drug targets for KRAS-driven cancers

High-speed method generates mini-protein binders with potential to become new class of drugs

Huddersfield cancer scientists aim to develop new treatments for young people

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Drug targeting approach could lead to improved therapies for immune-related diseases

New MRI contrast agent differentiates between aggressive and slow-growing breast cancers

'Labyrinth' chip may be new way to monitor cancer patients in clinical trials

Small-molecule immunotherapeutics could steer immune defense against fungal pathogens

Researchers design novel small antibody fragment with improved crystallizability

Study opens new door to potential treatments for highly lethal brain tumors

MIT engineers design more effective synthetic mRNA delivery system

Researchers explore new combination approach to treat high-risk soft-tissue sarcomas

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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