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Inherited traits and tumor mutations affect response to treatment of leukemia

The outcome of chemotherapy treatment for acute lymphoblastic leukemia (ALL) depends not only on the acquired genetic make-up of the leukemic cells, but on genes that children inherit from their parents. This study, from investigators at St. Jude Children's Research Hospital, is published in the online edition of Blood.

3 Mar 2005

Surgery gives normal life expectancy to patients with severe mitral regurgitation

"We know from previous studies that patients with symptomatic mitral regurgitation are at increased risk of death, but for those without symptoms the picture has been murkier," says Maurice Enriquez-Sarano, M.D., the Mayo Clinic cardiologist who led the study. "In this study we followed a large population of asymptomatic patients prospectively to identify keys to improved long-term outcomes, and to determine when patients should consider surgery."

2 Mar 2005

Amercan footballers are too fat

A new study by University of North Carolina endocrinologist Joyce Harp and student Lindsay Hecht suggests that as many 56 per cent of players in the National Football League are obese.

2 Mar 2005

Artery clearing device does not provide benefit for heart attack patients undergoing artery-opening interventions

Use of a device and system to clear dislodged "debris" during percutaneous interventions to open a blocked artery following a heart attack does not appear to be clinically beneficial, according to a study in the March 2 issue of JAMA.

1 Mar 2005

alpha-defensin-1, a protein found in immune cells, can control HIV infection

Theresa Chang and colleagues at Mount Sinai School of Medicine analyzed how alpha-defensin-1 inhibits HIV infection in white blood cells (CD4+ T cells). Defensins have been shown to have anti-HIV activity. The body attempts to protect itself from HIV infection via the innate immune system.

1 Mar 2005

African-Americans receive less aggressive treatment for heart attack than whites

According to a study at the Maya Angelou Research Center on Minority Health at Wake Forest University Baptist Medical Center, African-Americans continue to receive less aggressive treatment for heart attack than whites.

1 Mar 2005

Small hearts make big difference for young transplant recipients

When a young child is in need of a heart transplant, the problem is not the intricate surgery, but the scarcity of donors.

1 Mar 2005

Radiopharmaceuticals and lasers produce sound to treat and detect cancerous moles

When treating skin cancer, differentiating between melanoma and healthy moles can be difficult. Doctors must know the shape of the cancer and how deep it is before treating the problem. Now, a skin care specialist at the University of Missouri-Columbia has teamed with MU engineering and internal medicine professors to develop a better identification and treatment process.

1 Mar 2005

Research into how prions act in the brain could hold the key to defeating diseases

Scientists at the University of Southampton are continuing their pioneering research into diseases such as Creutzfeld-Jakob Disease (CJD) and related conditions caused by tiny particles known as prions, thanks to a £300,000 grant from the Medical Research Council.

1 Mar 2005

New research offers natural alternative to arthritis drugs

The research, conducted by The Australian Centre for Complementary Medicine Education and Research (ACCMER), shows that Biolane Green Lipped Mussel Extract has a combination of actions that are not associated with increased risk of blood clotting that has caused recent drug withdrawals and medical warnings. In fact, the product may even help slow the progression of osteoarthritis.

1 Mar 2005

Scientists re-produce the human body's own cancer-killing cells through gene therapy

New hope to cancer sufferers comes from research by South Korean scientists who have found a way to re- produce the human body's own cancer-killing cells through gene therapy.

1 Mar 2005

Growing evidence base supports focus on mind-body connection in heart disease

Cardiologists should recognize and help manage depression, stress and other common psychosocial risk factors that play a powerful role in the wellbeing and health outcomes of heart disease patients, according to an article(PDF) in the March 1, 2005 issue of the Journal of the American College of Cardiology.

1 Mar 2005

Some immune cells are smarter than others killing more cancer

In efforts to educate the body to fight off cancer, researchers have found that some immune cells are "smarter" than others. Working with collections of human cells, Johns Hopkins Kimmel Cancer Center scientists tested kill-rates of two kinds of T-cells "primed" to home in on myeloma, a cancer of the bone marrow. Those that live in the bone marrow outperformed their counterparts circulating in the blood by more than 90 percent.

1 Mar 2005

Genetic link to kidney damage after heart surgery

Specific variants of genes involved in inflammation and blood vessel constriction are strongly associated with kidney damage in patients undergoing major heart surgery, researchers at Duke University Medical Center have found.

1 Mar 2005

Nose cells provide a window into the brain

In the first study to examine living nerve cells from patients with psychiatric disease, scientists from the Monell Chemical Senses Center, the University of Pennsylvania, and collaborating institutions report altered nerve cell function in olfactory receptor neurons from patients with bipolar disorder.

1 Mar 2005

Celebrex provides a two pronged attack against prostate cancer

Celecoxib, a selective COX-2 inhibitor with promising anti-cancer properties, has now been found to attack prostate cancer cells in a second way that differs from Vioxx (rofecoxib), another anti-inflammatory drug that also inhibits COX-2.

1 Mar 2005

New cancer drug Avastin keeps cancer under control

Data published for the first time today in the leading Journal of Clinical Oncology showed that the unique new cancer drug Avastin keeps cancer under control for a significantly longer duration, even when used in a group of elderly patients with advanced colorectal cancer who are too sick to tolerate traditional aggressive chemotherapy.

1 Mar 2005

OPAL, major discovery in the fight against AIDS

Australian researchers have made a major discovery in the fight against AIDS, with the development of a novel, simple and safe technique for boosting the body’s immune response to deadly viruses like HIV, which is even effective against drug resistant forms of the disease.

1 Mar 2005

Encouraging results in wet age-related macular degeneration study

Novadaq Technologies has announced that Dr. Giovanni Staurenghi, (Associate Professor of Ophthalmology, Department of Otorhinolaryngological and Ophthalmological Science University of Milan, Italy), reported preliminary data on 24-patients in an on-going study using the Company's proprietary technology to treat wet Age-Related Macular Degeneration (AMD).

28 Feb 2005

Unique study of the use of deep brain stimulation

Canadian researchers have seen promising results from a unique study of the use of deep brain stimulation (DBS), in severely depressed patients resistant to standard treatments.

28 Feb 2005