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Cornell research provides new insight into chemotherapy agent's effect on DNA

New Cornell research is providing a fresh view into the ways a common chemotherapy agent, etoposide, stalls and poisons the essential enzymes that allow cancer cells to flourish.

30 Jan 2023

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Scientists at La Jolla Institute for Immunology (LJI) have uncovered the structure and function of the first FDA-approved treatment for Zaire ebolavirus (Ebola virus).

30 Jan 2023

Researchers develop AI-based strategy for discovering high-affinity antibody drugs

Scientists at University of California San Diego School of Medicine have developed an artificial intelligence (AI)-based strategy for discovering high-affinity antibody drugs.

30 Jan 2023

New discovery about microglia heralds myriad possibilities for treating neurodegenerative diseases

Combating Alzheimer's and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality.

30 Jan 2023

Researchers discover mechanism underlying the development and intensification of cancer treatment-related pain

A combination of chemotherapy and drugs that stimulate the immune system to combat cancer is increasingly used to control progression of the disease in patients.

30 Jan 2023

Guidance for diagnosing and managing migraine

Migraine is a major cause of disability, affecting about 12% of people. A 2-part series published in CMAJ (Canadian Medical Association Journal) on diagnosing and managing the condition with both acute and preventive therapy provides guidance for clinicians.

30 Jan 2023

Machine learning identifies drugs that could be repurposed to help people quit smoking cigarettes

Medications like dextromethorphan, used to treat coughs caused by cold and flu, could potentially be repurposed to help people quit smoking cigarettes, according to a study by Penn State College of Medicine and University of Minnesota researchers.

30 Jan 2023

Scientists explore potential new ways to prevent and treat optic nerve hypoplasia

As the number of children born with a vision-impairing condition known as optic nerve hypoplasia (ONH) increases, scientists with the Fralin Biomedical Research Institute at VTC are investigating potential ways to prevent and treat the disease.

30 Jan 2023

$1 million grant will help University of Utah chemists to speed up the drug development process

Michael Grünwald, Ryan Looper and Rodrigo Noriega, of the University of Utah Department of Chemistry, received a $1 million grant from the W.M. Keck Foundation funding studies of currently unpredictable aspects of the process of crystallization.

30 Jan 2023

New research changes the paradigm of how people think about graft-versus-host disease

New research challenges the prevailing hypothesis for how donor stem cell grafts cause graft-versus-host disease, or GVHD, and offers an alternative model that could guide development of novel therapies.

30 Jan 2023

Novel class of sulfonamides to block malaria transmission

Malaria is a devastating disease, with 247 million cases and 619,000 deaths reported in 2021 alone. Malaria causes fever and a flu-like illness that occurs when people are infected with the parasite Plasmodium falciparum, which is spread by mosquitoes.

30 Jan 2023

Researchers design contact lens prototype to prevent dry eye syndrome

A collaborative team from the Terasaki Institute for Biomedical Innovation has developed a contact lens prototype that is specifically designed to prevent contact lens-induced dry eye (CLIDE).

30 Jan 2023

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore, led by Associate Professor Takaomi Sanda and Dr Lim Fang Qi, has breathed new life into an existing drug—combatting a type of blood cancer called T-cell acute lymphoblastic leukemia, or T-ALL.

30 Jan 2023

International guidelines to help prevent and treat heart complications in pediatric oncology patients

The world's first international clinical guidelines to help prevent and treat heart complications in children undergoing cancer treatment have been created.

29 Jan 2023

Using systems biology research to alter the properties of carcinogenic cells in the lungs

KAIST (President Kwang Hyung Lee) announced on January 30th that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering succeeded in using systems biology research to change the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

29 Jan 2023

Antiviral activity of natural flavonoids against various coronaviruses

A recent study describes the binding affinity and docking sites of several natural compounds, as well as their inhibitory activity against 3CLpro.

29 Jan 2023

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

The vital role of oxytocin - the "love hormone" - for social attachments is being called into question. More than forty years of pharmacological and behavioral research has pointed to oxytocin receptor signaling as an essential pathway for the development of social behaviors in prairie voles, humans, and other species, but a genetic study publishing in the journal Neuron on January 27 shows that voles can form enduring attachments with mates and provide parental care without oxytocin receptor signaling.

29 Jan 2023

Doctoral research presents predictive value of biomarkers for inflammatory bowel diseases

Under the supervision of four professors from the UMCG departments of Gastroenterology and Hepatology and Pathology and Medical Biology, Bourgonje conducted doctoral research on the predictive value of biomarkers for inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis.

29 Jan 2023

Biology underlying pair bonding and parenting may not be dictated by oxytocin receptors, study shows

Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years.

27 Jan 2023

Treatment to boost white blood cells may benefit patients with glioblastoma

A new study led by Washington University School of Medicine in St. Louis reveals at least one cause of low white blood cell counts in patients treated for glioblastoma and demonstrates a potential treatment strategy that improves survival in mice.

27 Jan 2023

Drugs News and Research

Cornell research provides new insight into chemotherapy agent's effect on DNA

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Researchers develop AI-based strategy for discovering high-affinity antibody drugs

New discovery about microglia heralds myriad possibilities for treating neurodegenerative diseases

Researchers discover mechanism underlying the development and intensification of cancer treatment-related pain

Guidance for diagnosing and managing migraine

Machine learning identifies drugs that could be repurposed to help people quit smoking cigarettes

Scientists explore potential new ways to prevent and treat optic nerve hypoplasia

$1 million grant will help University of Utah chemists to speed up the drug development process

New research changes the paradigm of how people think about graft-versus-host disease

Novel class of sulfonamides to block malaria transmission

Researchers design contact lens prototype to prevent dry eye syndrome

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

International guidelines to help prevent and treat heart complications in pediatric oncology patients

Using systems biology research to alter the properties of carcinogenic cells in the lungs

Antiviral activity of natural flavonoids against various coronaviruses

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

Doctoral research presents predictive value of biomarkers for inflammatory bowel diseases

Biology underlying pair bonding and parenting may not be dictated by oxytocin receptors, study shows

Treatment to boost white blood cells may benefit patients with glioblastoma

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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