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Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Researchers step closer to cure for common childhood cancer

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of white blood cells (WBC) in the bone marrow and blood. ALL is the most common cancer occurring in children with an annual rate of approximately 30 to 40 new cases per million.

5 Dec 2004

Hydroxyurea plus aspirin best therapy in patients with essential thrombocythemia who are at high risk for vascular events

A new treatment for an incurable blood disorder proves a worse option for patients' health than an older treatment, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Genetic target found for pediatric leukemia

A molecular target newly discovered by scientists at two prestigious research institutes may pave the way for new treatments that could combat an aggressive form of leukemia, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

A new treatment for patients with chronic myeloid leukemia

A new treatment for patients with chronic myeloid leukemia (CML) -- a disorder marked by an overproduction of white blood cells -- yields positive results in those who have relapsed on imatinib, the standard treatment for the disease, according to a Phase I study to be presented today at the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Data from phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia

At the 46th Annual Meeting of the American Society of Hematology (ASH) preliminary data were presented from a phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia (MDS).

5 Dec 2004

Single dose phase I data on CG53135 for the prevention of oral mucositis

CuraGen Corporation has announced results presented from a Phase I clinical trial with CG53135 for the prevention of oral mucositis (OM) in patients receiving high dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (AHSCT) at the ASH 46th Annual Meeting in San Diego, CA.

5 Dec 2004

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

An oral targeted therapy gentle enough to be used by patients in their 70s or 80s is showing benefit in treating high-risk myelodysplastic syndrome (MDS), a pre-leukemic disorder that can progress to acute myelogenous leukemia (AML)

4 Dec 2004

Implications of twin, triplet and quadruplet pregnancies on mothers

More women giving birth in their later years has given rise to fertility treatments which has in turn led to what can be described as an explosion in twin, triplets and quadruplet pregnancies.

4 Dec 2004

Herpes virus offers new hope in search for cure for cancer

In laboratory studies at Cincinnati Children's Hospital Medical Center, researchers have successfully treated the most common malignant abdominal tumor of childhood: neuroblastoma tumors.

4 Dec 2004

Research raises question on shark cartilage use as an anti-cancer treatment

The rising popularity of shark cartilage extract as an anti-cancer treatment is a triumph of marketing and pseudoscience over reason, with a tragic fallout for both sharks and humans, according to a Johns Hopkins biologist writing in the Dec. 1 issue of Cancer Research.

4 Dec 2004

Study focused on patients with chemotherapy-related anemia

Findings from an interim analysis of a new study comparing the hemoglobin response rates of Epoetin alfa and darbepoetin alfa in the treatment of chemotherapy-related anemia were published in the November 15, 2004 issue of the Medical Journal 'Blood' as part of the American Society of Hematology 46th Annual Meeting and Exposition.

4 Dec 2004

Life expectancy at 65 is now 81.6 years for men and 84.5 for women

The nation’s medicine cabinets are more crowded than ever, with almost half of all people taking at least one prescription medicine and one in six taking three or more medications, according to the U.S. Department of Health and Human Services’ annual check-up on Americans’ health.

4 Dec 2004

New noninvasive technique allows for early detection of chemotherapy treatment response

Scientists at the Arizona Cancer Center have developed an approach that will allow them to detect if cancer patients are responding within days after they start a new chemotherapy regimen.

4 Dec 2004

Fossil record of the human immune system reveals antibodies that block cancer metastasis

A team of researchers at The Scripps Research Institute has reconstructed the "fossil record" of the immune systems of a group of human cancer patients to investigate if they had ever produced antibodies against their disease.

4 Dec 2004

Pfizer submits regulatory filings for Revatio (sildenafil citrate) as a treatment for pulmonary arterial hypertension

Sildenafil is the active ingredient in Viagra, Pfizer's erectile dysfunction medication used by more than 23 million men worldwide.

4 Dec 2004

A vitamin B pill that drastically lowers blood levels of homocysteine could one day be used to prevent dementia

High blood levels of homocysteine are a risk factor for stroke and dementia, including Alzheimer’s disease. Raised levels damage nerves and blood vessels, and lead to a loss of brain tissue in patients.

4 Dec 2004

Daily meditation helps middle schoolers lower their blood pressure and heart rate

Students who used a simple concentration-based breathing mediation technique significantly reduced their resting and "active" blood pressure, according to Frank A. Treiber, Ph.D., and colleagues at the Medical College of Georgia. Their findings appear in the journal Psychosomatic Medicine.

4 Dec 2004

Low level exposure to Benzene causes lower blood cell counts

A new study found that white blood cell counts were lowered in workers exposed to less than 1 ppm of the chemical benzene (part benzene per million parts air).

3 Dec 2004

Blood News and Research

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Researchers step closer to cure for common childhood cancer

Hydroxyurea plus aspirin best therapy in patients with essential thrombocythemia who are at high risk for vascular events

Genetic target found for pediatric leukemia

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

A new treatment for patients with chronic myeloid leukemia

Data from phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia

Single dose phase I data on CG53135 for the prevention of oral mucositis

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

Implications of twin, triplet and quadruplet pregnancies on mothers

Herpes virus offers new hope in search for cure for cancer

Research raises question on shark cartilage use as an anti-cancer treatment

Study focused on patients with chemotherapy-related anemia

Life expectancy at 65 is now 81.6 years for men and 84.5 for women

New noninvasive technique allows for early detection of chemotherapy treatment response

Fossil record of the human immune system reveals antibodies that block cancer metastasis

Pfizer submits regulatory filings for Revatio (sildenafil citrate) as a treatment for pulmonary arterial hypertension

A vitamin B pill that drastically lowers blood levels of homocysteine could one day be used to prevent dementia

Daily meditation helps middle schoolers lower their blood pressure and heart rate

Low level exposure to Benzene causes lower blood cell counts

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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