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Advanced technique could pave way for cascade of new steroidal therapeutics

Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process, published in the journal Nature Chemistry, facilitates access to rare, mirror-image isomers of naturally occurring steroid structures.

26 Sep 2017

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow.

22 Sep 2017

Study identifies two genes involved in invasive group A Streptococcus infections

Group A Streptococcus bacteria cause a variety of illnesses that range from mild nuisances like strep throat to life-threatening conditions including pneumonia, toxic shock syndrome and the flesh-eating disease formally known as necrotizing fasciitis.

22 Sep 2017

Temporomandibular disorder may increase frequency and severity of chronic migraine

In a study, researchers at the University of São Paulo's Ribeirão Preto School of Medicine, in Brazil, finds that the more frequent the migraine attacks, the more severe will be the so-called temporomandibular disorder, or TMD. The temporomandibular joint acts like a sliding hinge connecting the jawbone to the skull, therefore the disorder's symptoms includes difficulty chewing and joint tension.

22 Sep 2017

New tissue-chip research aims to speed drug development for two genetic forms of epilepsy

An interdisciplinary team of Vanderbilt University researchers has received a two-year, $2-million federal grant to develop an "organ-on-chip" model for two genetic forms of epilepsy. These disorders affect both brain and heart and improved modeling could lead to new drug treatments.

22 Sep 2017

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now.

21 Sep 2017

Researchers assess self-monitoring of blood glucose behavior among diabetes patients in China

Researchers in China who assessed self-monitoring of blood glucose behavior among nearly 19,000 patients with type 2 diabetes treated with oral medications reported very low SMBG rates both before and after the patients began treatment with basal insulin, although the data showed an increase in mean SMBG frequency after 6 months and the percentage of patients who never monitored their blood glucose decreased.

21 Sep 2017

Researchers identify new genetic test to help predict cancer recurrence

Researchers have discovered a new genetic test which could help predict cancer recurrence - paving the way for more precise, personalized treatments.

21 Sep 2017

Researchers design novel small antibody fragment with improved crystallizability

Antibodies are a powerful weapon system in defending our body against invaders such as bacteria and viruses. Each antibody consists of four polypeptide chains: two heavy chains and two light chains joined to form a Y-shaped molecule.

21 Sep 2017

Researchers receive $11.5 million program project grant to eliminate drug resistant malaria

Texas Biomedical Research Institute researchers, Dr. Tim Anderson and Dr. Ian Cheeseman, have partnered with researchers at the University of Notre Dame and the Center for Infectious Disease Research in Seattle to pursue studies in drug resistant malaria.

20 Sep 2017

Alcohol use may induce changes to cholesterol-regulating gene

In an analysis of the epigenomes of people and mice, researchers at Johns Hopkins Medicine and the National Institutes of Health report that drinking alcohol may induce changes to a cholesterol-regulating gene.

20 Sep 2017

New collaboration could lead to novel drugs that address unmet medical needs

Southern Research and the University of Tennessee Health Science Center have formed a partnership to advance promising research that could lead to new drugs that address unmet medical needs.

20 Sep 2017

Carbohydrates on surface of malaria parasites could be key to effective vaccine

An international research team has shown for the first time that carbohydrates on the surface of malaria parasites play a critical role in malaria's ability to infect mosquito and human hosts.

18 Sep 2017

Scientists make significant discovery in efforts to develop vaccine against global pathogens

Scientists at the University of Southampton have made a significant discovery in efforts to develop a vaccine against Zika, dengue and Hepatitis C viruses that affect millions of people around the world.

15 Sep 2017

Penn study provides insight into how cells maintain identity during replication

Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any other time.

15 Sep 2017

FDA permits first digital therapeutic device for treatment of substance use disorders

The United States Food and Drug Administration (US FDA) yesterday – 14th of September 2017, permitted the marketing of an application developed for mobiles that would help in the treatment of substance use disorders (SUD).

14 Sep 2017

FDA moves to guard against abuse of ‘orphan drug’ program

The Food and Drug Administration is changing the way it approves medicines known as "orphan drugs" after revelations that drugmakers may be abusing a law intended to help patients with rare diseases.

13 Sep 2017

Study: New oral drug helps control glucose, reduces need for insulin in patients with type 1 diabetes

A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.

13 Sep 2017

JWARG begins study to identify suspected severe infectious diseases in West Africa

The Joint West Africa Research Group began a study today designed to identify cases of suspected severe infectious disease at medical centers in West Africa. The study is being led by the U.S. Military HIV Research Program of the Walter Reed Army Institute of Research.

13 Sep 2017

Protein research could pave way to potential treatments for neurodegenerative diseases

Research carried out at the University of Kent has the potential to influence the future search for treatment of neurodegenerative diseases that are linked to a family of protein molecules known as 'amyloid'.

11 Sep 2017

Therapeutics News and Research

Advanced technique could pave way for cascade of new steroidal therapeutics

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

Study identifies two genes involved in invasive group A Streptococcus infections

Temporomandibular disorder may increase frequency and severity of chronic migraine

New tissue-chip research aims to speed drug development for two genetic forms of epilepsy

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Researchers assess self-monitoring of blood glucose behavior among diabetes patients in China

Researchers identify new genetic test to help predict cancer recurrence

Researchers design novel small antibody fragment with improved crystallizability

Researchers receive $11.5 million program project grant to eliminate drug resistant malaria

Alcohol use may induce changes to cholesterol-regulating gene

New collaboration could lead to novel drugs that address unmet medical needs

Carbohydrates on surface of malaria parasites could be key to effective vaccine

Scientists make significant discovery in efforts to develop vaccine against global pathogens

Penn study provides insight into how cells maintain identity during replication

FDA permits first digital therapeutic device for treatment of substance use disorders

FDA moves to guard against abuse of ‘orphan drug’ program

Study: New oral drug helps control glucose, reduces need for insulin in patients with type 1 diabetes

JWARG begins study to identify suspected severe infectious diseases in West Africa

Protein research could pave way to potential treatments for neurodegenerative diseases

Industry Focus eBook - Microbiome (1st edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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