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Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers observed SARS-CoV-2 downregulates the expression of MHC class I molecules.

23 May 2022

Pioneering study could transform the treatment landscape for babies with infantile spasms

Infantile spasm (IS) is a severe epileptic syndrome of infancy and accounts for 50% of all epilepsy cases that occur in babies during the first year of life.

20 May 2022

Molecular target discovery opens new pathways for developing effective anti-angiogenic cancer therapy

Researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have identified a new molecular drug target that could result in new cancer drugs with fewer side effects.

20 May 2022

Exosomes derived from γδ-T cells synergized with radiotherapy can control nasopharyngeal carcinoma

A research team at LKS Faculty of Medicine, The University of Hong Kong discovered that exosomes derived from γδ-T cells (γδ-T-Exos) synergised with radiotherapy can control nasopharyngeal carcinoma (NPC) by overcoming the radioresistance of NPC cancer stem cells (CSCs) and preserve their tumor-killing and T cell-promoting activities in the immunosuppressive NPC microenvironment.

18 May 2022

Inflammation plays a key role in resolving pain

In a recent study published in the journal Science Translational Medicine, researchers explored the mechanisms underlying the transition from acute to chronic low back pain (LBP) by transcriptome-wide analysis of peripheral immune cells from acute LBP patients.

17 May 2022

Penn study finds low uptake of first mutation-targeted bladder cancer drug

The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

12 May 2022

Researchers Identify Potential Target for Rhabdomyosarcoma Recurrence Prevention

In this interview, News-Medical speaks to Anand Patel and Michael Dyer from St. Jude's Children's Research Hospital about their recent research suggesting EGFR inhibitors may prevent rhabdomyosarcoma recurrence.

12 May 2022

Rutgers study identifies key protein for brain stem cell longevity

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.

11 May 2022

Using silk proteins for tendon repair

Just mentioning a ruptured Achilles tendon would make anyone wince. Tendon injuries are well known for their lengthy, difficult and often incomplete healing processes.

3 May 2022

How diet and nutrition impacts lifespan

In a recent study published in the journal Cell, researchers analyzed the association between human longevity to growth and metabolic pathways.

1 May 2022

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

In a recent study published in Biomedicines, researchers explored the utility of natural killer (NK) cells in coronavirus disease 2019 (COVID-19).

28 Apr 2022

MAPK pathway mutations can provide “precision” treatment targets for head and neck cancer

About one-fifth of often deadly head and neck cancers harbor genetic mutations in a pathway that is key to normal cell growth, and scientists report those mutations, which enable abnormal cancer cell growth, can also make the cancer vulnerable.

28 Apr 2022

Research reveals a therapeutic opportunity to prevent rhabdomyosarcoma recurrence

Rhabdomyosarcoma is a type of soft tissue cancer. Scientists at St. Jude Children's Research Hospital studied the population of cells that persists after therapy, causing rhabdomyosarcoma recurrence.

27 Apr 2022

MCG scientists report how exercise can counter the damage of diabetes

One way exercise can counter the damage of diabetes is by enabling activation of a natural system we have to grow new blood vessels when existing ones are ravaged by this disease, scientists report.

26 Apr 2022

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

For more than two decades, University of Alabama at Birmingham researcher Susan Bellis, Ph.D., has studied how the addition of sialic acid to various proteins increases cancer resistance and oncogenicity.

22 Apr 2022

SARS-CoV-2 spike protein disrupts lipid metabolism resulting in liver, heart & kidney damage

A new study describes the impact of SARS-CoV-2 on host lipid metabolism.

21 Apr 2022

Treatment for retinal vein occlusion yields long-lasting vision gains, study shows

New research shows that a treatment for retinal vein occlusion yields long-lasting vision gains, with visual acuity remaining significantly above baseline at five years.

21 Apr 2022

Researchers uncover a new protective mechanism against non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is a prevalent disease frequently seen in obese people. Having high fat content in the liver is detrimental as it is strongly associated with severe health problems like diabetes, high blood pressure, and liver cancer.

20 Apr 2022

Levels of little-studied enzyme found to decline with age and more dramatically with Alzheimer’s

A little-studied enzyme has been found in high levels in healthy neurons, levels that scientists say decline with age and more dramatically with Alzheimer's, making adjusting the enzyme's level a potential treatment for both.

19 Apr 2022

The involvement of the skeletal muscles in long COVID-19

Researchers reviewed the mechanisms of muscle tissue injury, aggravating conditions, and associated sequelae in long COVID‐19.

18 Apr 2022