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Immunocompromised hosts with Delta/Omicron co-infections

A recent study posted to the medRxiv* preprint server examined clinical cases of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta/Omicron variants and Omicron BA.1/ BA.2 sublineages in immunocompromised (IC) patients.

10 Apr 2022

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

A new study investigates the combination of two small molecules that target the host cells and reports a synergistic antiviral activity in vitro against SARS-CoV-2.

7 Apr 2022

Study shows circular RNA vaccine provides robust protection against SARS-CoV-2 in mice and rhesus macaques

Researchers investigated the effectiveness of a circRNA vaccine against SARS-CoV-2 and its Delta and Omicron variants, which elicited significant antibody and T-cell responses in mice and rhesus macaques.

6 Apr 2022

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

A new study describes a new variant that resembles the SARS-CoV-2 Omicron BA.21 for the most part but has a small segment at the 3’ tip that belongs to the BA.1 variant.

5 Apr 2022

Study detects SARS-CoV-2 BA.1/BA.2 recombinant in two epidemiologically linked cases

Researchers have focussed on detecting BA.1/BA.2 recombinant in travelers through surveillance.

5 Apr 2022

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

A recent study posted to the bioRxiv* preprint server investigated the active genetic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), its emerging mutations, and the existence of antiviral resistance against Mpro inhibitors like paxlovid.

5 Apr 2022

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Researchers examined whether varied allelic frequencies of the HLA gene in people of different ancestral origins were associated with increased susceptibility to SARS-CoV-2 infection and disease severity.

4 Apr 2022

Evonetix granted patent for technology enabling thermally-controlled DNA synthesis

EVONETIX LTD (‘Evonetix’), the synthetic biology company bringing semiconductor technology to DNA synthesis, today announced it has been granted patent EP3551331B1 in Europe for its proprietary thermal control technology for DNA synthesis, as well as the design and manufacture of its silicon chips.

From Evonetix 4 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

A new study shows that multiple variants of this virus may coinfect the same patient, using both genomic sequencing data and computational models.

30 Mar 2022

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes respiratory coronavirus disease 2019 (COVID-19) triggered an unprecedented public health emergency. Human mobility patterns were fundamental to the spread of SARS-CoV-2 globally. The situation is particularly acute in a country like Saudi Arabia, which has seen more than 750,000 cases and over 9,000 deaths as of March 30th, 2022.

29 Mar 2022

Nucleotide News and Research

Immunocompromised hosts with Delta/Omicron co-infections

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

Study shows circular RNA vaccine provides robust protection against SARS-CoV-2 in mice and rhesus macaques

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

Study detects SARS-CoV-2 BA.1/BA.2 recombinant in two epidemiologically linked cases

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Evonetix granted patent for technology enabling thermally-controlled DNA synthesis

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

Characterization of the different expressed RNAseq variants in SARS-CoV-2 infected patients

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

Strand displacement mechanism in RNA appears to switch genetic expression from “on” to “off”

Study investigates recombinant SARS-CoV-2 variants in immunocompromised individuals

Clinical determinants of post-COVID-19 thromboembolism

Impact of truncated open reading frame 8 protein variants of SARS-CoV-2

Researchers characterize vaccines for infectious bronchitis virus

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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