Polymerase News and Research

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Smoking alters lung microbiome, leading to loss of diversity and community structure

Research investigates the impact of smoking on the lower respiratory tract microbiome. The study found that smoking results in a loss of diversity in the microbiome, changes in co-occurrence patterns, and a weakening of the tight community structure present in healthy microbiomes.

26 Apr 2023

The epidemiology of SARS-CoV-2 in white-tailed deer

Researchers explored the epidemiological factors of SARS-CoV-2 in white-tailed deer.

26 Apr 2023

A rapid and affordable in vitro model to test SARS-CoV-2 susceptibility in animal species

Research investigates the susceptibility of seven bat species to SARS-CoV-2 by expressing their ACE2 receptor in a non-permissive avian cell line. The study found that all seven bat species were susceptible to SARS-CoV-2, but the level of virus replication differed between bat species and virus variants.

24 Apr 2023

Researchers pioneer a new method for fast miRNA amplification and detection

In the early 1990s, scientists who were studying the development of a roundworm identified a small RNA molecule that regulated the expression of specific genes.

24 Apr 2023

What are the trends in severe outcomes among patients hospitalized with COVID-19 during the first 2 years of the COVID-19 pandemic?

Researchers documented surveillance across a network of 155 acute care hospitals in Canada between March 15, 2020, and May 28, 2022.

24 Apr 2023

Study identifies an unknown SARS-CoV-2 lineage on three mink farms in Poland

Researchers detected a cryptic severe acute respiratory syndrome coronavirus 2 lineage on mink farms in Poland.

24 Apr 2023

Novel self-amplifying RNA vaccine confers durable protection against COVID-19, reduces viral shedding in primate study

A self-amplifying replicon RNA vaccine against SARS-CoV-2 can elicit durable and protective immunity in pigtail macaques, even after neutralizing antibody responses have waned to undetectable levels.

23 Apr 2023

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

CMPK2 identified as a potential pan-flavivirus inhibitor, restricting virus replication and providing a basis for developing new antiviral treatments.

23 Apr 2023

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Research explains how the SARS-CoV-2 virus spreads efficiently by directly infecting neighboring cells through a process called cell-to-cell transmission. The virus uses a protein called occludin (OCLN) to enter the cells and causes syncytium formation, which leads to viral spread.

20 Apr 2023

Can SARS-CoV-2 infection cause diabetes?

This paper reports a population-based cohort study conducted in British Columbia, Canada, which found that SARS-CoV-2 infection is associated with a higher risk of diabetes, particularly among those with severe COVID-19 disease.

19 Apr 2023

Understanding the probable transmission of SARS-CoV-2 from lion to zookeepers

Researchers explored the possible transmission of SARS-CoV-2 to zoo employees from an African lion.

19 Apr 2023

Is there an association between exposure to ultrafine particles during pregnancy and influenza infection severity?

Researchers explored the impact of exposure to ultrafine particles during pregnancy on the risk of influenza.

19 Apr 2023

Lactobacillus probiotics improve vaginal health in asymptomatic women

This study investigated the effect of administering Lactobacillus probiotics (LBPs) on vaginal dysbiosis in asymptomatic women. The results showed that oral intake of LBPs improved vaginal health in women with high Nugent scores.

17 Apr 2023

Does school attendance facilitate greater SARS-CoV-2 spread?

Researchers performed a descriptive cross-sectional study in Ireland during the academic year 2020–21.

17 Apr 2023

Is there an association between COVID-19 and the risk of developing an autoimmune disease?

Researchers reviewed data on the incidence of autoimmune diseases in the post-acute coronavirus disease 2019 period.

17 Apr 2023

Pregnant women show unique immune response to COVID-19

Researchers compare the adaptive, innate, and humoral immune responses between pregnant and non-pregnant women with COVID-19.

16 Apr 2023

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

Researchers investigate whether SARS-CoV-2 and its variants have evolved to evade CD8+ T cell-mediated immunity.

15 Apr 2023

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Researchers present the crystal structure of an anti-non-structural protein 9 specific nanobody in complex with the SARS-CoV-2 nsp9.

15 Apr 2023

Antibody response to SARS-CoV-2 is stronger and more durable in infants and young children

Researchers evaluated humoral responses to severe acute respiratory syndrome coronavirus 2 in infants.

15 Apr 2023

Monovalent and bivalent COVID boosters provide strong protection against severe outcomes in older adults

Researchers examined the effectiveness of SARS-CoV-2 booster doses in preventing severe Omicron infection outcomes.

15 Apr 2023

Polymerase News and Research

Smoking alters lung microbiome, leading to loss of diversity and community structure

The epidemiology of SARS-CoV-2 in white-tailed deer

A rapid and affordable in vitro model to test SARS-CoV-2 susceptibility in animal species

Researchers pioneer a new method for fast miRNA amplification and detection

What are the trends in severe outcomes among patients hospitalized with COVID-19 during the first 2 years of the COVID-19 pandemic?

Study identifies an unknown SARS-CoV-2 lineage on three mink farms in Poland

Novel self-amplifying RNA vaccine confers durable protection against COVID-19, reduces viral shedding in primate study

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Can SARS-CoV-2 infection cause diabetes?

Understanding the probable transmission of SARS-CoV-2 from lion to zookeepers

Is there an association between exposure to ultrafine particles during pregnancy and influenza infection severity?

Lactobacillus probiotics improve vaginal health in asymptomatic women

Does school attendance facilitate greater SARS-CoV-2 spread?

Is there an association between COVID-19 and the risk of developing an autoimmune disease?

Pregnant women show unique immune response to COVID-19

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Antibody response to SARS-CoV-2 is stronger and more durable in infants and young children

Monovalent and bivalent COVID boosters provide strong protection against severe outcomes in older adults

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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