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Study indicates widespread SARS-CoV-2 exposure in wildlife

In a recent study posed to the bioRxiv* preprint server, researchers at Virginia Tech University investigated wildlife exposure to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).

8 Nov 2022

Outcomes from an Australian COVID-19 virtual ward during Omicron wave

In a recent study posted to the medRxiv* preprint server, researchers in Australia characterized hospitalization volumes, patient epidemiological and clinical outcome data of patients admitted to virtual wards during the predominance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) BA.1 sub-VOC and the Omicron BA.2 sub-VOC.

8 Nov 2022

Study identifies novel inhibitors against SARS-CoV-2 main protease

In a recent study posted to the bioRxiv* server, researchers at the University of Arizona screened ~11 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro)-inhibiting small compounds in the ZINC15 database using a structure-based in-silico screening method.

8 Nov 2022

Study shows consistent efficacy of Paxlovid regardless of age, number of vaccinations, comorbidities

In a recent study posted to the medRxiv* preprint server, researchers in Canada evaluated nirmatrelvir and ritonavir (Paxlovid) effectiveness against severe coronavirus disease 2019 (COVID-19) during the dominance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) and Omicron sub-VOCs in Canada.

7 Nov 2022

Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virus

Researchers used whole genome sequencing to evaluate monkeypox virus samples from Washington and Ohio states in the United States and identified 25 samples with open reading frame (ORF)-disrupting mutations.

7 Nov 2022

Evaluating dual direct-acting antivirals against persistent COVID-19

Researchers assessed the efficiency of dual direct-acting antivirals in treating persistent coronavirus disease 2019 (COVID-19).

7 Nov 2022

Does the time of day patients receive their COVID-19 vaccinations influence their clinical benefit?

Researchers investigated whether the time of day at which COVID-19 patients receive their SARS-CoV-2 vaccinations influences the vaccine effectiveness.

7 Nov 2022

The transmission dynamics of the monkeypox outbreak in the UK

Researchers analyzed monkeypox virus transmission dynamics among United Kingdom residents.

7 Nov 2022

Study shows likely SARS-CoV-2 transmission between different rooms of a quarantine hotel

The results of this study, published in the Emerging Infectious Diseases journal, underline the enhanced transmissibility of the Omicron variants of the virus, which takes advantage of small airstreams to jump to new hosts. "Our findings emphasize the importance of ventilation and integrity of building structure in quarantine facilities."

6 Nov 2022

Exploring BNT162b2 vaccine effectiveness against COVID-19 among pediatric and adolescent population of Qatar

Researchers evaluated Pfizer-BioNTech’s BNT162b2 messenger ribonucleic acid (mRNA) vaccine effectiveness (VE) against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infections among the pediatric and adolescent population of Qatar.

4 Nov 2022

What were the SARS-CoV-2 seroprevalence estimates for industrial livestock operation workers in the USA for 2021-2022?

In a new study, researchers measured SARS-CoV-2 seroprevalence in industrial livestock operation workers of North Carolina, United States, between February 2021 and July 2022.

4 Nov 2022

Persistent COVID-19 symptoms among South Africans infected during SARS-CoV-2 Beta, Delta and Omicron variant waves

Researchers longitudinally followed up hospitalized (H) and non-hospitalized (NH) COVID-19 patients for six months after laboratory-confirmed SARS-CoV-2 infections to identify factors that increase the risk of post-COVID-19 condition development in the South African population.

4 Nov 2022

Efficacy of booster messenger ribonucleic acid COVID-19 vaccinations against SARS-CoV-2 Omicron variant severity

Researchers estimated the effectiveness of monovalent messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) infection severity outcomes among adults.

4 Nov 2022

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Monkeypox has infected more than 77,000 people in more than 100 countries worldwide, and -; similar to COVID-19 -; mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines in its mission to infect more people.

4 Nov 2022

Circadian disruption induces weight gain through changes in gut microbiota

In a recent study published in the journal Molecular Metabolism, researchers investigated the impact of environmental and genetic disruptions of the circadian rhythms on the peripheral circadian clock synchronization and microbiome oscillations in the gastrointestinal tract.

3 Nov 2022

What is the correlation between specific COVID-19 clinical characteristics and anti-SARS-CoV-2 antibody titers?

Researchers investigated the associations between clinical characteristics of coronavirus disease 2019 (COVID-19) and immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 Nov 2022

Scientists identify a cryptic SARS-CoV-2 lineage in wastewater

In a recent study posted to the medRxiv* preprint server, researchers in the United States investigated the source of an enigmatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC)-like spike (S) protein strain detected in wastewater but not in clinical samples.

2 Nov 2022

Polymerase News and Research

Study indicates widespread SARS-CoV-2 exposure in wildlife

Outcomes from an Australian COVID-19 virtual ward during Omicron wave

Study identifies novel inhibitors against SARS-CoV-2 main protease

Study shows consistent efficacy of Paxlovid regardless of age, number of vaccinations, comorbidities

Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virus

Evaluating dual direct-acting antivirals against persistent COVID-19

Does the time of day patients receive their COVID-19 vaccinations influence their clinical benefit?

The transmission dynamics of the monkeypox outbreak in the UK

Study shows likely SARS-CoV-2 transmission between different rooms of a quarantine hotel

Exploring BNT162b2 vaccine effectiveness against COVID-19 among pediatric and adolescent population of Qatar

What were the SARS-CoV-2 seroprevalence estimates for industrial livestock operation workers in the USA for 2021-2022?

Persistent COVID-19 symptoms among South Africans infected during SARS-CoV-2 Beta, Delta and Omicron variant waves

Efficacy of booster messenger ribonucleic acid COVID-19 vaccinations against SARS-CoV-2 Omicron variant severity

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Circadian disruption induces weight gain through changes in gut microbiota

What is the correlation between specific COVID-19 clinical characteristics and anti-SARS-CoV-2 antibody titers?

Scientists identify a cryptic SARS-CoV-2 lineage in wastewater

Vimentin is an important co-receptor for SARS-CoV-2 infection

Nebulized mRNA-encoded antibodies found to protect hamsters against COVID-19

Effectiveness of prior infection in preventing reinfection with SARS-CoV-2 Omicron BA.2.75 sublineage

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Changing the landscape of R&D to build clinical success from the ground up

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