Polymerase Chain Reaction News and Research

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Polymerase chain reaction (PCR) is a revolutionary laboratory technique that enables the replication of a specific DNA sequence. Using PCR, millions of copies of a target DNA can be easily synthesized within a short period of time.

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Researchers evaluated the efficacy of low-dosage fluvoxamine (50 mg two times a day) over 10 days in the management of mild and moderate-SARS-CoV-2 infections in the US.

18 Jan 2023

Exploring a novel amplicon-based mpox virus sequencing strategy

Researchers described the development of a sequencing strategy based on amplicons for mpox detection.

18 Jan 2023

An in-depth meta-analysis highlights COVID-19's pregnancy dangers

Researchers assess the risk of maternal, fetal, and neonatal morbidity and mortality in women diagnosed with COVID-19 during pregnancy.

17 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

Researchers developed a computational workflow based on molecular dynamic (MD) simulations and artificial neural network (ANN) to assess the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD)-human angiotensin-converting enzyme 2 (hACE2) binding affinities of SARS-CoV-2 variants.

17 Jan 2023

S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

Researchers assessed the impact of Staphylococcus aureus (S. aureus) on SARS-CoV-2 replication.

17 Jan 2023

Researchers explore immune responses to mpox infections

In new research, researchers demonstrated that individuals recovering from mpox virus (MPXV) infection have neutralizing antibodies that target MPXV antigens A35R and H3L.

17 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

Study finds non-Omicron breakthrough infections elicit robust cross-neutralizing activity against Omicron variants across the antigenic barrier

Researchers assessed the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with a non-Omicron variant on SARS-CoV-2 BA.4/5 neutralization.

17 Jan 2023

New test 'fishes' for multiple respiratory viruses using DNA as 'bait'

A new test that 'fishes' for multiple respiratory viruses at once using single strands of DNA as 'bait', and gives highly accurate results in under an hour, has been developed by Cambridge researchers.

16 Jan 2023

Researchers report that vectored expression of a high-affinity ACE2 microbody protein establishes a high degree of protection from SARS-CoV-2

Researchers evaluated the use of receptor decoys for SARS-CoV-2 based on soluble forms of ACE2 for immunological prophylaxis and management of COVID-19 through the use of AAV vectors.

16 Jan 2023

Intranasal mRNA-lipid nanoparticle vaccines elicit significant protection against SARS-CoV-2 in hamsters

Researchers from the United States evaluated the efficacy and immunogenicity of an intranasal messenger ribonucleic acid (mRNA)-lipid nanoparticle (LNP) vaccine against SARS-CoV-2 using a hamster model.

16 Jan 2023

The long-term clinical outcomes of SARS-CoV-2 infection in people with mild disease in Israel

Researchers conducted a nationwide study in Israel to determine the post-acute sequelae of SARS-CoV-2 a year after mild COVID-19.

16 Jan 2023

What is the efficacy of the COVID-19 second booster versus the first booster with prior COVID-19 infections?

Researchers assessed the efficacy of the COVID-19 second booster vaccine compared to the first booster vaccine and the protection conferred by prior COVID-19 infection.

16 Jan 2023

Study investigates the spectrum of antibody immunity across several SARS-CoV-2 variants

Researchers evaluated antibody responses to the spike proteins of the SARS-CoV-2 Wuhan-Hu-1 strain and VOCs such as the Alpha, Beta, Gamma, Delta, and Omicron.

16 Jan 2023

Researchers study bacterial co-infections and antibiotic use in COVID-19 patients

Researchers estimated the frequency of bacterial co-infections among hospitalized coronavirus disease 2019 (COVID-19) patients and of antibiotic prescriptions in the initial COVID-19 period for appraising the usage of antibiotic stewardship criteria.

13 Jan 2023

Discovery of a potential new target for new MPOX or broad pox vaccines

In a recent study posted to the medRxiv* preprint server, researchers in the United Kingdom developed a pooled enzyme-linked immunosorbent (ELISA) assay using mpox (MPX) virus (MPXV) antigens and vaccinia virus (VACV) antigens. They also assessed humoral responses to and identification of antigens of MPXV IIa clade and IIb clade, in comparison to recipients of smallpox vaccines (ACAM2000 and IMVANEX).

12 Jan 2023

Study on the ecology of viruses in urban rodents with special emphasis on SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers investigated whether commensal rodent pests such as rats and mice, sourced from sewers and urban settings, are exposed to and are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They also investigated viruses present in commensal rodents.

12 Jan 2023

The 2022 U.S. RSV surge consisted of a variety of pre-existing viruses

In a recent study posted to the medRxiv* preprint server, researchers investigated whether the upsurge in respiratory syncytial virus (RSV) infections during the autumn season of 2022 occurred due to the emergence of a novel, highly transmissible RSV strain or whether multiple pre-existing RSV strains were responsible for the increase in RSV case counts during the period.

12 Jan 2023

COVID-19 booster doses could significantly reduce the incidence of SARS-CoV-2 infection among young adults

A recent study published in the journal PLOS Medicine examined the effectiveness of booster doses of coronavirus disease 2019 (COVID-19) vaccines in protecting vaccinated young adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during the dominant period of the Omicron BA.1 variant.

12 Jan 2023

Polymerase Chain Reaction News and Research

Further Reading

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Exploring a novel amplicon-based mpox virus sequencing strategy

An in-depth meta-analysis highlights COVID-19's pregnancy dangers

What are the major findings of long COVID research?

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

Researchers explore immune responses to mpox infections

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Study finds non-Omicron breakthrough infections elicit robust cross-neutralizing activity against Omicron variants across the antigenic barrier

New test 'fishes' for multiple respiratory viruses using DNA as 'bait'

Researchers report that vectored expression of a high-affinity ACE2 microbody protein establishes a high degree of protection from SARS-CoV-2

Intranasal mRNA-lipid nanoparticle vaccines elicit significant protection against SARS-CoV-2 in hamsters

The long-term clinical outcomes of SARS-CoV-2 infection in people with mild disease in Israel

What is the efficacy of the COVID-19 second booster versus the first booster with prior COVID-19 infections?

Study investigates the spectrum of antibody immunity across several SARS-CoV-2 variants

Researchers study bacterial co-infections and antibiotic use in COVID-19 patients

Discovery of a potential new target for new MPOX or broad pox vaccines

Study on the ecology of viruses in urban rodents with special emphasis on SARS-CoV-2

The 2022 U.S. RSV surge consisted of a variety of pre-existing viruses

COVID-19 booster doses could significantly reduce the incidence of SARS-CoV-2 infection among young adults

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo