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Maternal gut bacteria linked to changes in fetal brain metabolism

The impact of Bifidobacterium breve's presence in the maternal gut during pregnancy on fetal brain metabolism.

23 Aug 2024

The impact of stem cells on the epigenetic clock

How old are you, really? Your chronological age is the number of years you have been alive. Your biological age is how old your cells are which scientists believe may better assess one's age-related health and disease risk. People biologically age at different rates, depending on genetic and environmental factors, so that a person's chronological age does not necessarily match their biological age. In recent years, direct-to-consumer biological age tests have become increasingly accessible and popular as interest has increased in this nascent science.

23 Aug 2024

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice leads to a decrease in epithelial cell turnover and lipid malabsorption, particularly impacting the absorption of vitamin E, which is crucial for maintaining neurological health. The researchers further explored the impact of these changes on the gut-liver axis and found alterations in the expression of genes related to bile acid synthesis.

23 Aug 2024

Study sheds light on the dual nature of cellular senescence

Scientists at Sanford Burnham Prebys and the La Jolla Institute for Immunology have revealed a new secret regarding senescence, a cellular state similar to sleep that is more likely to affect aged cells.

22 Aug 2024

New insights into macrophages' role in MASH and liver fibrosis

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function.

22 Aug 2024

Potential antitumoral effects of Manuka honey in breast cancer models

Researchers evaluated the antitumor activity of Manuka honey on human breast cancer cells and its underlying molecular mechanisms in both in vitro and in vivo preclinical models.

22 Aug 2024

DNA scavengers break down antibiotic-resistant genes

For nearly a century, scientists have waged war on antibiotic-resistant microbes. Michigan State University researchers say they've found a new way to prevent it – by unleashing "DNA scavengers" in wastewater treatment plants.

22 Aug 2024

Protein encoded by the ASPN gene plays a protective role in pulmonary arterial hypertension

A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).

21 Aug 2024

Fasting and ketogenic diet reveal new vulnerability of pancreatic tumors to existing cancer drug

Researchers examine the role of fasting and ketogenesis in regulating protein synthesis and its potential implications for cancer therapy.

21 Aug 2024

Exploring targeted therapies in the complex landscape of multiple myeloma

Multiple myeloma (MM) is a complex hematological malignancy with significant unmet needs. While conventional therapies have significantly improved patient survival, the disease remains incurable.

20 Aug 2024

Study links gut microbe depletion to lifelong respiratory allergies

Researchers at the University of British Columbia have shown for the first time how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies.

20 Aug 2024

Innovative light-activated shunt could reduce surgeries for children with heart defects

Children born with defects that impair the heart's lower chambers undergo a series of invasive surgeries early in life.

19 Aug 2024

New $300,000 grant aims to enhance hydroponic lettuce production

As controlled environment agriculture and vertical farming gain a greater foothold in modern agriculture, a new $300,000 grant aims to enhance hydroponic lettuce production.

16 Aug 2024

Researchers reveal why a diet rich in magnesium is so important for your health

Researchers examined whether magnesium deficiency in the healthy middle-aged Australian population was independently or in combination with increased homocysteine levels associated with in vivo DNA damage.

15 Aug 2024

Cell adhesion and starvation found to be key drivers of pattern formation in keratinocytes

Cell-cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion, Hokkaido University researchers find.

12 Aug 2024

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

In a groundbreaking study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer's disease, and schizophrenia.

12 Aug 2024

Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

Researchers have discovered a brain-gut circuit that links stress to changes in gut bacteria, revealing that emotional states can directly influence immune function through the duodenal glands.

11 Aug 2024

EZH2's role in cancer progression and therapy explored

Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of the Polycomb-repressive complex 2 (PRC2), which plays a crucial role in transcriptional repression through the methylation of histone H3 on lysine 27 (H3K27me3).

9 Aug 2024

Lensless fluorescence detection system provides highly sensitive water quality assessment

Researchers have shown that a fluorescence detection system that doesn't contain any lenses can provide highly sensitive detection of deadly microorganisms in drinking water. With further development, the new approach could provide a low-cost and easy-to-use way to monitor water quality in resource-limited settings such as developing countries or areas affected by disasters. It could also be useful when water safety results are needed quickly, such as for swimming events, a concern highlighted during the Paris Olympics.

9 Aug 2024

Korean researchers accelerate race for respiratory disease cures

The COVID-19 pandemic has profoundly impacted our lives, claiming nearly 7.1 million lives globally. Scientists and medical professionals have been working tirelessly to understand the virus, its transmission pathways, and effective treatments. The urgency of developing vaccines and treatments has never been greater, prompting calls for Korea to expedite its drug development efforts to match those of developed countries. Recently, a team of Korean researchers has made a breakthrough that will greatly enhance the efficiency of respiratory disease research, garnering attention.

9 Aug 2024