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Research shows how bacteria inactivate common drug used to treat cancers

To the reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study published today in Science, researchers describe findings that certain bacteria can be found inside human pancreatic tumors.

18 Sep 2017

EPFL scientists discover metabolic differences between hepatoblastoma subtypes

Hepatoblastoma is a rare pediatric liver cancer, usually diagnosed in the first three years of life. Histological methods are used to distinguish between the different subtypes of hepatoblastoma.

18 Sep 2017

LSUHealthNO to examine effectiveness of novel drug designed for heart muscle regeneration

In collaboration with Novo Biosciences, Inc., LSU Health New Orleans Cardiovascular Center of Excellence will receive more $500,000 over two years to study the effectiveness of a novel drug designed to stimulate the regeneration of heart muscle and prevent the formation or scar tissue following a heart attack.

15 Sep 2017

Steroid hormones could provide new insight into age-related bone loss

A group of steroid hormones could provide new insight into the bone loss and deterioration that occurs with aging, researchers at the Medical College of Georgia at Augusta University report.

15 Sep 2017

BWH researchers discover new genetic cause for photosensitive blood disorder

Researchers from BWH have uncovered a new genetic cause for erythropoietic protoporphyria (EPP), a photosensitive blood disorder. In the past, the most well-known causes for EPP were two specific genetic disorders, but using an extended pedigree from France, the investigators found that EPP can also be caused by changes in another gene.

14 Sep 2017

Researchers identify natural compound that appears to shut down cancer cells' energy source

The Warburg Effect describes a phenomenon in which cancer cells voraciously consume glucose for energy -- something scientists have long known, yet have had little success exploiting as a way to stunt tumor growth.

14 Sep 2017

Probiotics may become new preventative or therapeutic strategy for IBD-related colon cancer

In an innovative approach to colorectal cancer (CRC) prevention and treatment, scientists are studying ways to replace missing metabolites in patients prone to gut inflammation and CRC.

14 Sep 2017

Researchers find unique genetic mutation in 74-year-old man with Parkinson's disease

Mutations in the human genome may be responsible for many diseases. In the case of Parkinson's disease (PD), five locations have been the subject of recent attention. Variants of one of these locations, ACMSD (aminocarboxymuconate semialdehyde decarboxylase), may be implicated in PD, but until now, no mutations in ACMSD have been found in any PD patients.

14 Sep 2017

MTI awards $25,000 grant to MDI Biological Laboratory scientist for peripheral neuropathy research

The Maine Technology Institute has awarded a $25,000 seed grant to Sandra Rieger, Ph.D., of the MDI Biological Laboratory to study peripheral neuropathy, a condition that causes pain, tingling and numbness in the hands and feet and affects an estimated 20 to 40 million Americans.

13 Sep 2017

Study uncovers how inflammation contributes to key feature of diabetes

A new study by researchers at the University of Maryland School of Medicine has uncovered how inflammation contributes to a key feature of diabetes, the body's inability to metabolize glucose, a condition known as insulin resistance.

12 Sep 2017

Epigenetic changes triggered by cigarette smoke may be earliest step in lung cancer development

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called "epigenetic" changes in the cells consistent with the earliest steps toward lung cancer development.

12 Sep 2017

Researchers discover major mechanism in development of liver cancer

Liver cancer is the second-leading cause of cancer-related death and represents the fastest rising cancer worldwide. In most cases, the tumor develops in patients with chronic liver disease.

11 Sep 2017

Compounds in fermented fish paste inhibit enzyme involved in cholesterol synthesis

Compounds in a fermented fish paste used as a condiment in Indonesia efficiently inhibit an enzyme involved in cholesterol synthesis, reports a study published in the Pertanika journal Tropical Agricultural Science.

11 Sep 2017

Drugs used for treatment of high cholesterol may benefit patients with cirrhosis

Statins used for the treatment of high cholesterol may have other beneficial effects, but there has been reluctance to prescribe them to patients with liver disease because of concerns that they may cause abnormal liver enzyme levels in the blood.

11 Sep 2017

Study: Maintenance therapy increases progression-free survival in BRCA mutant recurrent ovarian cancer

Rucaparib maintenance therapy increases progression-free survival in BRCA mutant recurrent ovarian cancer by 77%, according to late-breaking results from the ARIEL3 trial reported today at the ESMO 2017 Congress in Madrid.

8 Sep 2017

Penn researcher wins National Cancer Institute Outstanding Investigator Award

M. Celeste Simon, PhD, who studies cancer cell metabolism, tumor immunology, and the influence of oxygen availability and deprivation on tumor growth, has been given a National Cancer Institute Outstanding Investigator Award.

8 Sep 2017

Neuroscientists discover new signaling pathway that could be good drug target to fight chronic pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain.

8 Sep 2017

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Significant headway has been made in controlling malaria. However, two vexing problems remain: currently available treatments are unable to block transmission of the parasite that causes the disease, and the parasite often becomes resistant to drugs.

7 Sep 2017

Study sheds light on virulence strategy of intracellular bacteria that cause legionellosis

Intracellular pathogens adopt various strategies to circumvent the defences of the host cell and to proliferate intracellularly. One specific strategy is to target host organelles like the mitochondria. Mitochondria are well-defined cytoplasmic organelles, which take part in a variety of cellular metabolic functions.

7 Sep 2017

Exploration of human genetics reveals new targets to combat heart disease

Again and again, it's the rare among humans that help the rest of us. The exploration of human genetics is revealing new targets to combat heart disease among atypical variants. Mutations in genes that play a role in heart health are the inspiration for a cluster of new heart drugs.

7 Sep 2017

Enzyme News and Research

Research shows how bacteria inactivate common drug used to treat cancers

EPFL scientists discover metabolic differences between hepatoblastoma subtypes

LSUHealthNO to examine effectiveness of novel drug designed for heart muscle regeneration

Steroid hormones could provide new insight into age-related bone loss

BWH researchers discover new genetic cause for photosensitive blood disorder

Researchers identify natural compound that appears to shut down cancer cells' energy source

Probiotics may become new preventative or therapeutic strategy for IBD-related colon cancer

Researchers find unique genetic mutation in 74-year-old man with Parkinson's disease

MTI awards $25,000 grant to MDI Biological Laboratory scientist for peripheral neuropathy research

Study uncovers how inflammation contributes to key feature of diabetes

Epigenetic changes triggered by cigarette smoke may be earliest step in lung cancer development

Researchers discover major mechanism in development of liver cancer

Compounds in fermented fish paste inhibit enzyme involved in cholesterol synthesis

Drugs used for treatment of high cholesterol may benefit patients with cirrhosis

Study: Maintenance therapy increases progression-free survival in BRCA mutant recurrent ovarian cancer

Penn researcher wins National Cancer Institute Outstanding Investigator Award

Neuroscientists discover new signaling pathway that could be good drug target to fight chronic pain

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Study sheds light on virulence strategy of intracellular bacteria that cause legionellosis

Exploration of human genetics reveals new targets to combat heart disease

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