MTI awards $25,000 grant to MDI Biological Laboratory scientist for peripheral neuropathy research

The Maine Technology Institute (MTI) has awarded a $25,000 seed grant to Sandra Rieger, Ph.D., of the MDI Biological Laboratory to study peripheral neuropathy, a condition that causes pain, tingling and numbness in the hands and feet and affects an estimated 20 to 40 million Americans.

The one-year grant will allow Rieger to collaborate with scientists from the University of New England (UNE) in Biddeford, Maine, to ascertain if compounds she previously identified as preventing or somewhat reversing peripheral neuropathy in zebrafish are also effective in rats.

The research in rats, which are mammals like humans, is an important step in moving the compounds into human clinical studies. Currently, no treatments for peripheral neuropathy exist, except for symptoms such as pain.

"We are focused on the discovery and development of new regenerative medicine therapies," said Kevin Strange, Ph.D., MDI Biological Laboratory president. "By funding early-stage research with commercial potential such as Sandra Rieger's, MTI is playing a critical role in building Maine's biomedical sector and creating new science and technology jobs."

The causes of peripheral neuropathy include cancer chemotherapy, diabetes, antibiotic treatment and other conditions. Rieger studies peripheral neuropathy induced by Taxol (paclitaxel), a common chemotherapy agent. She has identified two compounds that have the potential to prevent or reverse the potentially disabling condition.

The compounds Rieger has discovered are the subject of a provisional patent issued to the MDI Biological Laboratory last year. Part of the MTI seed grant will be used to pursue the full patent for the use of these compounds.

"We are very grateful to MTI," Rieger said. "We hope to commercialize new therapies to treat chemotherapy-induced peripheral neuropathy in humans. The research in rats is a critical next step in that process. With the help of the MTI funding and the University of New England, we can now move ahead with the development of these therapies."

Rieger has linked peripheral neuropathy to an increase in MMP-13 (matrix metalloproteinase-13), an enzyme that degrades collagen, which holds the skin together. The degradation of the skin causes degeneration of the sensory nerve endings, which leads to peripheral neuropathy. The compounds Rieger discovered inhibit MMP-13 activity.

Rieger also recently received a grant totaling $1.8 million from the National Cancer Institute to fund the continuation of her studies in zebrafish. That grant will also fund a collaborative study with the Mayo Clinic in Rochester, Minn., to test the clinical relevance of her findings in breast cancer patients treated with Taxol.

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