Muscle News and Research

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New research reveals b1-integrin protein as promising therapeutic target for muscle aging

As we age, the function and regenerative abilities of skeletal muscles deteriorate, which means it is difficult for the elderly to recover from injury or surgery. New work from Carnegie's Michelle Rozo, Liangji Li, and Chen-Ming Fan demonstrates that a protein called b1-integrin is crucial for muscle regeneration.

6 Jul 2016

European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

Amgen has announced that the European Commission (EC) has approved a variation to the marketing authorization for Kyprolis® (carfilzomib) to include use in combination with dexamethasone alone for adult patients with multiple myeloma who have received at least one prior therapy. The extended indication marks the second approval for Kyprolis by the EC in less than a year.

6 Jul 2016

Alnylam reports new results from investigational RNAi therapeutic programs

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today preliminary results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, both investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis).

6 Jul 2016

Health care resource use and costs of H.P. Acthar® gel for multiple sclerosis relapse

Mallinckrodt plc, a leading global specialty biopharmaceutical company, today announced new retrospective health economic data on H.P. Acthar® Gel (repository corticotropin injection; RCI), which may be an option for the management of multiple sclerosis (MS) relapses.

6 Jul 2016

Body image-related problems growing among male individuals

It’s referred to as the opposite of anorexia – muscle dysmorphia – but men with body-building and other body image issues are up to four times more likely than females to be undiagnosed and it is a growing public health problem.

4 Jul 2016

Novel anti-interleukin 1-alpha antibody shows promise in treating advanced colorectal cancer patients

A novel anti-interleukin 1-alpha antibody has shown a significant impact on symptoms, and a high level of safety and tolerability in patients with advanced colorectal cancer, according to phase III data presented at the European Society for Medical Oncology's 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain.

4 Jul 2016

Researchers use gelation chips to develop strong muscle fibers

USC researcher Megan L. McCain and colleagues have devised a way to develop bigger, stronger muscle fibers. But instead of popping up on the bicep of a bodybuilder, these muscles grow on a tiny scaffold or "chip" molded from a type of water-logged gel made from gelatin.

1 Jul 2016

Breakthrough research could lead to new drugs to improve heart attack outcomes

A research advance from the Sanford Burnham Prebys Medical Discovery Institute and Stanford University could lead to new drugs that minimize the damage caused by heart attacks.

30 Jun 2016

Study highlights continuing problem of MSI in Gulf War veterans

Veterans of the Gulf War are more than twice as likely to have medically unexplained symptoms known as "multisymptom illness" (MSI), compared to Iraq/Afghanistan War veterans, according to an updated research review in the July Journal of Occupational and Environmental Medicine, official publication of the American College of Occupational and Environmental Medicine.

30 Jun 2016

Stem cell procedure may be safe for ALS patients

A phase II clinical trial in people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, suggests that transplanting human stem cells into the spinal cord may be done safely.

30 Jun 2016

New electric mesh device wraps around the heart to deliver electrical impulses

A research team led by investigators at Beth Israel Deaconess Medical Center and Seoul National University has developed a new electric mesh device that can be wrapped around the heart to deliver electrical impulses and thereby improve cardiac function in experimental models of heart failure, a major public health concern and leading cause of mortality and disability.

29 Jun 2016

Scientists develop novel bionic cardiac patch to treat heart problems

Scientists and doctors in recent decades have made vast leaps in the treatment of cardiac problems - particularly with the development in recent years of so-called "cardiac patches," swaths of engineered heart tissue that can replace heart muscle damaged during a heart attack.

28 Jun 2016

LIF-treated muscle stem cells show promise in treatment of muscular dystrophy

Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro.

28 Jun 2016

Jefferson researchers discover alternate pathway that helps heart keep pumping

About 5.7 million Americans have heart failure, half of whom will die from the disease within 5 years, according to the Centers for Disease Control and Prevention.

28 Jun 2016

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Appetite, as a word, come from the Latin appetitus, meaning "desire for.” Therefore, appetite can be defined as a pleasurable sensation or the desire to eat. This sensation is coordinated by several brain areas associated with reward processing such amygdala, hippocampus, ventral pallidum, nucleus accumbens and striatum, and others.

28 Jun 2016

Researchers receive grant to improve quality of donor limb, tissue for transplant

A Case Western Reserve University School of Medicine faculty member has received $998,500 from the U.S. Department of Defense to develop a new approach to improve the quality and quantity of limbs and tissues obtained from brain dead organ donors.

27 Jun 2016

Blood mannose levels could help predict type 2 diabetes risk

Even if you are not overweight, your mannose levels may indicate whether you're at risk for type 2 diabetes (T2D) or insulin resistance (IR), a Swedish study shows.

27 Jun 2016

Study shows one in five individuals from U.S. military sample have obesity

Despite being held to stringent weight and body fat standards, newly published research shows that one in five individuals from a sample of U.S. military personnel from 2001 - 2008 have obesity.

27 Jun 2016

Re-engineering cardiac scarring process could improve clinical outcomes for heart disease patients

Literal heartbreak, from illness or injury, triggers the body's natural healing mechanisms.

25 Jun 2016

The future of simulated teaching methods

In healthcare, we have physicians, nurses and paramedics who know the textbook by heart and know exactly what they need to do, but have never experienced the procedure first-hand, or they have no experience responding to adverse events that may occur.

24 Jun 2016