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Researchers develop 'Trojan horse' approach to destroy cancer cells

Cancer cells are killed in lab experiments and tumour growth reduced in mice, using a new approach that turns a nanoparticle into a 'Trojan horse' that causes cancer cells to self-destruct, a research team at the Nanyang Technological University, Singapore (NTU Singapore) has found.

23 Sep 2020

Diabetes leads to drastic reduction in the kidney's potential to clean itself

The kidneys often become bulky and dysfunctional in diabetes, and now scientists have found that one path to this damage dramatically reduces the kidney's ability to clean up after itself.

22 Sep 2020

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity, especially in lung and colorectal cancers, reports a new study led by City of Hope and other renowned comprehensive cancer centers.

22 Sep 2020

Black breast cancer patients experience more delays in treatment initiation, duration than white women

One in seven black women with breast cancer had delays in starting treatment, and black women also had extended duration of treatment, according to a study led by UNC Lineberger Comprehensive Cancer Center researchers.

21 Sep 2020

Immunotherapy benefits patients with gastric and esophageal cancers, new data shows

New data presented at ESMO 2020 have shown that immunotherapy is beneficial for patients with gastric and esophageal cancers who currently have poor survival.

21 Sep 2020

Researchers identify a compound that inhibits growth of schwannomas

Schwannomas are tumors of the peripheral nervous system, which often occur in the genetic disease neurofibromatosis type 2. The research group of Prof. Dr. Helen Morrison at the Leibniz Institute on Aging - Fritz Lipmann Institute in Jena, Germany, identified a compound that inhibits the growth of such tumors and improves nerve function.

21 Sep 2020

PROfound phase III results offer new targeted treatment for metastatic prostate cancer

Results from the PROfound phase III study, funded by AstraZeneca and Merck Sharp & Dohme, open up a much-needed new treatment avenue for the more precise and effective treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease has progressed with hormonal therapy.

21 Sep 2020

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefits.

21 Sep 2020

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to results from a study at ESMO 2020.

21 Sep 2020

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Novel sequencing method could be useful for COVID-19 research

Researchers at the University of Chicago and the Cleveland Clinic have presented a novel single-cell RNA sequencing method that could be a useful application for research into the current coronavirus disease 2019 (COVID-19) pandemic.

20 Sep 2020

Trial shows new first-line treatment option for patients with metastatic kidney cancer

The results of the phase 3 CheckMate 9ER trial have provided a new first-line treatment option for patients with metastatic kidney cancer. The late breaking results are presented at ESMO 2020.

19 Sep 2020

New insights into human genetics

Who are we? Where did we come from? How did we get here? Throughout the ages, humans have sought answers to these questions, pursuing wisdom through religion, philosophy, and eventually science.

19 Sep 2020

Discovery could help enhance the effectiveness of immunotherapy against melanoma

Researchers at the University of Bern have discovered a mechanism in the body’s own immune system which is responsible for the maturation and activation of immune cells.

19 Sep 2020

Enhancing the efficacy of anti-PD-L1 immunotherapy for cancer

For most people, there is no scarier diagnosis than that of cancer. While treatments including chemotherapy and radiotherapy have been used since the 1940s and late 1800s, respectively, immunotherapy has more recently emerged as a viable and successful approach to cancer treatment.

18 Sep 2020

Tumor News and Research

Researchers develop 'Trojan horse' approach to destroy cancer cells

Diabetes leads to drastic reduction in the kidney's potential to clean itself

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

Black breast cancer patients experience more delays in treatment initiation, duration than white women

Immunotherapy benefits patients with gastric and esophageal cancers, new data shows

Researchers identify a compound that inhibits growth of schwannomas

PROfound phase III results offer new targeted treatment for metastatic prostate cancer

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

Novel sequencing method could be useful for COVID-19 research

Trial shows new first-line treatment option for patients with metastatic kidney cancer

New insights into human genetics

Discovery could help enhance the effectiveness of immunotherapy against melanoma

Enhancing the efficacy of anti-PD-L1 immunotherapy for cancer

Ineffective immune responses may be responsible for COVID-19 mortality rates in men and the elderly

Cellular recyclers could be used to eliminate the driver of cancer's aggressiveness

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

Study finds wide variation in levels and anti-tumor effectiveness of a common cancer drug

PPI use linked to worse outcomes in urothelial cancer patients treated with atezolizumab

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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