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Old antibiotic nitroxoline suggested as a treatment for MPOX

In a recent study posted to the bioRxiv* server, researchers in Germany investigated the effectiveness of the antibiotic nitroxoline against the currently circulating mpox viruses, previously called monkeypox virus (MPXV). This antibiotic has been used in Europe for about fifty years and has been proven effective in fighting biofilm infections.

3 Jan 2023

New study to examine the effectiveness of stroke treatment for patients with disabilities

When conducting clinical research, investigators aim to control as many variables as possible so it is easier to examine the effectiveness of new treatments.

3 Jan 2023

Age-related macular degeneration reported to confer higher risk of severe SARS-CoV-2 infection

Recent evidence has emerged to suggest that age-related macular degeneration (AMD) is a clinical risk factor for increased risk for infection and mortality.

3 Jan 2023

Phase III trial shows noninferiority of VV116 compared to nirmatrelvir–ritonavir among adults with mild-to-moderate COVID-19 at risk of progression

Researchers presented the results of a phase III randomized controlled trial of oral SARS-CoV-2 antiviral VV116.

3 Jan 2023

Want a clue on health care costs in advance? New tools take a crack at it

Need medical treatment this year and want to nail down your out-of-pocket costs before you walk into the doctor's office? There's a new tool for that, at least for insured patients.

3 Jan 2023

Mouse study identifies potential targets for treating dry eye disease and corneal injury

People with a condition known as dry eye disease are more likely than those with healthy eyes to suffer injuries to their corneas.

2 Jan 2023

UKB resident awarded the C. E. Alken Prize for outstanding scientific uro-oncological research

Dr. Niklas Klümper, resident at the Clinic for Urology and working group leader at the Institute for Experimental Oncology at the University Hospital Bonn (UKB), was awarded the C. E. Alken Prize in recognition of his outstanding scientific uro-oncological work.

30 Dec 2022

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

As a chronic pro-inflammatory disease, obesity is closely associated with the development of various diseases such as type 2 diabetes, cardiovascular disease and cancers. Obesity is now a major concern for public health.

30 Dec 2022

Study suggests a strategy for preventing the progression of chronic leukemia to aggressive disease

A study from Washington University School of Medicine in St. Louis suggests a strategy for preventing a chronic, slow-growing type of blood cancer from progressing to an aggressive form of leukemia.

29 Dec 2022

Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro

Researchers evaluated the efficacy of small molecule drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro.

29 Dec 2022

All patients with rheumatic disorders recommended to receive pneumococcal vaccine

Patients with rheumatoid arthritis, lupus, and other rheumatic conditions are more at risk for complications and death from pneumonia, meningitis, and other bacterial infections, yet most have not been vaccinated against infection.

29 Dec 2022

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

NCI-led clinical trial results in the first approval of a treatment for advanced alveolar soft part sarcoma

A clinical trial led by the National Cancer Institute (NCI), part of the National Institutes of Health, has resulted in the first approval of a treatment for advanced alveolar soft part sarcoma (ASPS).

28 Dec 2022

Scientists gain new insights into the opposing actions of serotonin-producing nerve fibers in mice

New insights into the opposing actions of serotonin-producing nerve fibers in mice could lead to drugs for treating addictions and major depression.

28 Dec 2022

Scientists explore synthesis of griffithsin in cell-free systems

A new study described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein.

28 Dec 2022

New test detects biomarker of Alzheimer's disease neurodegeneration in blood samples

A group of neuroscientists led by a University of Pittsburgh School of Medicine researcher developed a test to detect a novel marker of Alzheimer's disease neurodegeneration in a blood sample. A study on their results was published today in Brain.

28 Dec 2022

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Insilico Medicine ("Insilico"), a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that the company's drug discovery team has nominated a preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy utilizing its end-to-end Pharma.AI platform.

27 Dec 2022

Drugs News and Research

Old antibiotic nitroxoline suggested as a treatment for MPOX

New study to examine the effectiveness of stroke treatment for patients with disabilities

Age-related macular degeneration reported to confer higher risk of severe SARS-CoV-2 infection

Phase III trial shows noninferiority of VV116 compared to nirmatrelvir–ritonavir among adults with mild-to-moderate COVID-19 at risk of progression

Want a clue on health care costs in advance? New tools take a crack at it

Mouse study identifies potential targets for treating dry eye disease and corneal injury

UKB resident awarded the C. E. Alken Prize for outstanding scientific uro-oncological research

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

Study suggests a strategy for preventing the progression of chronic leukemia to aggressive disease

Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro

All patients with rheumatic disorders recommended to receive pneumococcal vaccine

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

NCI-led clinical trial results in the first approval of a treatment for advanced alveolar soft part sarcoma

Scientists gain new insights into the opposing actions of serotonin-producing nerve fibers in mice

Scientists explore synthesis of griffithsin in cell-free systems

New test detects biomarker of Alzheimer's disease neurodegeneration in blood samples

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Wafer-thin device could drastically alter the course of treatment for Type 1 diabetes

Cost-effectiveness analysis of four interventions for treatment of cancer-associated thrombosis

Cell-based method can predict how breast cancer patients will respond to treatments

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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