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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Research may help explain how liquid organelles in cells coexist without merging

New research may help to explain an intriguing phenomenon inside human cells: how wall-less liquid organelles are able to coexist as separate entities instead of just merging together.

10 Oct 2019

CRISPR RNA-cutting enzyme programmed to destroy viruses in human cells

Many of the world's most common or deadly human pathogens are RNA-based viruses -- Ebola, Zika and flu, for example -- and most have no FDA-approved treatments.

10 Oct 2019

New microneedle insulin pill avoids injections, applies insulin to gut wall

Quite a few drugs such as insulin are made up of protein and hence can’t be taken internally, as the gut breaks them down, rendering them useless. Thus these have to be administered by injection, and in the case of drugs that have to be taken several times a day this is a definite limitation.

10 Oct 2019

Using tape strips to obtain skin biomarkers in children with atopic dermatitis

Applying strips of adhesive tape to skin lesions and non-lesional skin is a non-invasive way to obtain biomarkers to track the severity of early-onset pediatric eczema or atopic dermatitis in infants and young children, researchers report for the first time.

9 Oct 2019

Cell discovery could help fight against liver disease

Scientists have identified new sub-types of cells that, when they interact, accelerate the scarring process in diseased livers.

9 Oct 2019

Novel cancer-driving mutation discovered in vast non-coding regions of the cancer genome

An Ontario-led research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the "dark matter" of human cancer DNA.

9 Oct 2019

Vaccine for deadly RSV could be on the way, scientists say

A vaccine for the common and sometimes deadly RSV (respiratory syncytial virus) has been elusive, but scientists say a new discovery puts them much closer to success.

9 Oct 2019

Scientists discover new patterns in the evolution of the influenza virus

Researchers from Skoltech have found that the devious influenza virus is capable of new patterns of evolution and mutation in order to escape treatment with the currently available drugs and prevention with the currently available vaccines. This discovery however could help researchers predict the potential mutations in the genome of the virus and ultimately help them develop and design more effective vaccines against influenza.

9 Oct 2019

Differences at the single-cell level can predict responses to BRAF inhibitor therapy

Patients with advanced melanoma have been able to live longer because of several newly approved targeted treatment options, including BRAF and MEK inhibitors. However, patients will often have different responses to the same treatment due to genetic variability.

8 Oct 2019

Study reveals link between alterations in RNA splicing and Alzheimer's disease

A collaborative study published today in the journal Cell Reports provides evidence for a new molecular cause for neurodegeneration in Alzheimer's disease.

8 Oct 2019

Histone modifications play important role in 'zygotic genome activation'

Scientists at Tokyo Institute of Technology observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to "histone H3", one of the proteins around which DNA is bound, play an important role in "zygotic genome activation" or transition of control of zebrafish embryonic development from maternal material to the zygote .

8 Oct 2019

New way to prevent malaria bugs from breeding

A new international collaboration reports that the compound called TCMDC-135051 is capable of preventing the synthesis of a protein that is required for growth in Plasmodium falciparum, one of the species of the Plasmodium parasite that causes malaria. The study, reported in the journal Science, could lead to the development of a new antimalarial drug.

8 Oct 2019

Carnegie Mellon and Yale win NIH grant to advance gene editing technique

A research team from Carnegie Mellon University and Yale University will advance their innovative, synthetic nucleic acid-based gene editing technique under a new grant from the National Institutes of Health's Somatic Cell Genome Editing Program.

7 Oct 2019

Spatial Gene Expression Profiling of Neurological Disorders

In this interview, Cedric Uytingco discusses the key benefits of being able to visualize gene expression patterns in neurological samples.

From 10x Genomics, Inc. 7 Oct 2019

Video images offer real-time view into the kinetics of viral assembly

For the first time, researchers have captured images of the formation of individual viruses, offering a real-time view into the kinetics of viral assembly. The research provides new insights into how to fight viruses and engineer self-assembling particles.

4 Oct 2019

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that make up the urinary system- has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it.

4 Oct 2019

NUS researcher invents novel transfection technique to deliver DNA into immune cells

Immunotherapy is a promising cancer treatment that uses genetically modified immune cells to fight cancer. It can be used as a primary treatment or in combination with other treatments such as radiation and chemotherapy to slow down or stop the growth of cancer cells and prevent them from spreading to other parts of the body.

4 Oct 2019

Targeting two genetic faults in cancer cells could hold the key to treating leukemia

Faults in two genes directly work together to bring about the deadliest form of blood cancer, scientists have discovered in a study that could pave the way for better treatments.

4 Oct 2019

Researchers identify gene mutation that causes musculoskeletal problems in children

Researchers have identified a gene mutation that causes developmental delay, intellectual disability, behavioral abnormalities and musculoskeletal problems in children. The newly diagnosed condition, called NKAP-related syndrome, arises from mutations in the NKAP gene, which plays a key role in human development.

3 Oct 2019

RNA News and Research

Further Reading

Research may help explain how liquid organelles in cells coexist without merging

CRISPR RNA-cutting enzyme programmed to destroy viruses in human cells

New microneedle insulin pill avoids injections, applies insulin to gut wall

Using tape strips to obtain skin biomarkers in children with atopic dermatitis

Cell discovery could help fight against liver disease

Novel cancer-driving mutation discovered in vast non-coding regions of the cancer genome

Vaccine for deadly RSV could be on the way, scientists say

Scientists discover new patterns in the evolution of the influenza virus

Differences at the single-cell level can predict responses to BRAF inhibitor therapy

Study reveals link between alterations in RNA splicing and Alzheimer's disease

Histone modifications play important role in 'zygotic genome activation'

New way to prevent malaria bugs from breeding

Carnegie Mellon and Yale win NIH grant to advance gene editing technique

Spatial Gene Expression Profiling of Neurological Disorders

Video images offer real-time view into the kinetics of viral assembly

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

NUS researcher invents novel transfection technique to deliver DNA into immune cells

Targeting two genetic faults in cancer cells could hold the key to treating leukemia

Researchers identify gene mutation that causes musculoskeletal problems in children

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