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TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists from the Florida campus of The Scripps Research Institute have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

22 Dec 2016

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

Researchers at the Icahn School of Medicine at Mount Sinai are working on the basic science that lays the groundwork to finding a way to treat and prevent the Zika virus, a global health risk.

22 Dec 2016

Researchers find accumulation of tumor suppressor in liver after food withdrawal

Tumor suppressors stop healthy cells from becoming cancerous. Researchers from Charité - Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam-Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal.

21 Dec 2016

Fly study shows RNA pathway plays major role in normal health and longevity

Humans and other animals carry rogue sequences of DNA in their genomes called transposable elements. To prevent passing TEs to their offspring, they employ the piRNA pathway in their reproductive organs to block the elements from being active in their sperm and eggs.

21 Dec 2016

Wellcome Trust Sanger Institute establishes spin-out company, Microbiotica

Cambridge Innovation Capital plc, a Cambridge-based investor in technology and healthcare companies, and IP Group plc, the developer of intellectual property-based businesses, announce the creation of Microbiotica Ltd, a newly formed spin-out company from the UK’s Wellcome Trust Sanger Institute based at the Wellcome Genome Campus in Hinxton, Cambridge.

21 Dec 2016

Research sheds light on key genes essential to pathogenesis of Helicobacter pylori

Professor Frédéric Veyrier's most recent research, in collaboration with the team of Professor Hilde De Reuse at the Institut Pasteur, has shed light on key genes essential to the pathogenesis of Helicobacter pylori bacterium, which causes gastric infections.

21 Dec 2016

Study identifies four previously unknown genetic risk locations for primary sclerosing cholangitis

A study of unprecedented scale has led researchers to identify four previously unknown genetic risk locations for primary sclerosing cholangitis, a liver disease that lacks effective medical therapy.

20 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Researchers use DNA markers to differentiate harmless species from deadly bacteria

The virulent pathogen that causes the disease tularemia, or "rabbit fever," was weaponized during past world wars and is considered a potential bioweapon.

20 Dec 2016

Mayo Clinic scientists show how hungry liver cells find energy

In a recent Science Advances article, Mayo Clinic researchers show how hungry human liver cells find energy.

20 Dec 2016

Scientists identify novel protein pathway across cancer types that fuels tumor progression

Scientists at The Wistar Institute have identified a novel protein pathway across several types of cancer that controls how tumor cells acquire the energy necessary for movement, invasion and metastasis.

19 Dec 2016

People at increased risk of schizophrenia more likely to use cannabis, research finds

People who have a greater risk of developing schizophrenia are more likely to try cannabis, according to new research, which also found a causal link between trying the drug and an increased risk of the condition.

19 Dec 2016

Research finds link between p53 pathway and ribosome biogenesis, nucleotide metabolism in DBA

Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer.

17 Dec 2016

NIH-funded scientists work with three ‘omes’ to understand human health

Have you ever collected coins, cards, toy trains, stuffed animals? Did you feel the need to complete the set? If so, then you may be a completist. A completist will go to great lengths to acquire a complete set of something.

17 Dec 2016

Johns Hopkins scientists create bioinformatics tool to evaluate cancer driver gene prediction methods

In their search for new ways to treat cancer, many scientists are using a high-tech process called genome sequencing to hunt for genetic mutations that encourage tumor cells to thrive.

17 Dec 2016

Retinoblastoma protein plays larger role in tumor suppression, study finds

The Retinoblastoma protein (pRB) has long been studied for its role in cell growth and the prevention of cancer.

16 Dec 2016

Genes that control immune system play key role in predisposition to HPV-related tumors

A number of genetic variants associated with susceptibility to oral cavity and pharyngeal cancer have been described in an international study published in the journal Nature Genetics.

16 Dec 2016

New IDT webinar to highlight benefits of using RNP complexes for efficient genome modifications

Integrated DNA Technologies will host an informative webinar entitled ‘Ribonucleoprotein delivery of CRISPR-Cas9 reagents for increased gene editing efficiency’ on December 14, 2016.

9 Dec 2016

EUCAST experts say that genetic testing methods cannot be used to determine antimicrobial susceptibility

Experts at the European Committee on Antimicrobial Susceptibility Testing, who define the optimal drug concentrations to inhibit the growth of pathogens, have found that genetic methods cannot yet be used to test for susceptibility in a number of important bacterial species.

9 Dec 2016

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016

Genome News and Research

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

Researchers find accumulation of tumor suppressor in liver after food withdrawal

Fly study shows RNA pathway plays major role in normal health and longevity

Wellcome Trust Sanger Institute establishes spin-out company, Microbiotica

Research sheds light on key genes essential to pathogenesis of Helicobacter pylori

Study identifies four previously unknown genetic risk locations for primary sclerosing cholangitis

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Researchers use DNA markers to differentiate harmless species from deadly bacteria

Mayo Clinic scientists show how hungry liver cells find energy

Scientists identify novel protein pathway across cancer types that fuels tumor progression

People at increased risk of schizophrenia more likely to use cannabis, research finds

Research finds link between p53 pathway and ribosome biogenesis, nucleotide metabolism in DBA

NIH-funded scientists work with three ‘omes’ to understand human health

Johns Hopkins scientists create bioinformatics tool to evaluate cancer driver gene prediction methods

Retinoblastoma protein plays larger role in tumor suppression, study finds

Genes that control immune system play key role in predisposition to HPV-related tumors

New IDT webinar to highlight benefits of using RNP complexes for efficient genome modifications

EUCAST experts say that genetic testing methods cannot be used to determine antimicrobial susceptibility

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

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