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New project on ultrasound device for treatment of neuropathic pain to receive NIH funding

Researchers from Florida Atlantic University's Schmidt College of Medicine, in collaboration with Albany Medical College in New York, are among seven institutions nationwide selected to receive funding from the National Institutes of Health for their innovative pilot projects to enable new medical devices to diagnose and treat both acute and chronic disorders from neuropathic pain to mental illness.

15 Dec 2022

Scientists uncover how FoxH1 factor binds to specific points in the genome

Transcription factors are proteins that interact with DNA to regulate the function of some genes. Generally, a single transcription factor binds to several regions in the genome as it orchestrates complex cellular responses, which require the activation or inhibition of several genes.

15 Dec 2022

Extraordinary plasticity of the glucocorticoid receptor revealed

Glucocorticoids —such as cortisone— are among the most widely used anti-inflammatory drugs, and are used to treat asthma, psoriasis, organ transplantation and even COVID-19.

15 Dec 2022

Four genetic mutations linked to progressive multifocal leukoencephalopathy

New research has confirmed a strong link between four genetic mutations and progressive multifocal leukoencephalopathy (PML), a rare but often fatal brain infection that can be triggered by dozens of FDA-approved drugs.

14 Dec 2022

No benefit of low dose apixaban following acute COVID-19

The HEAL-COVID trial compared the efficacy of Apixaban to standard care in adults who have recently recovered from severe COVID-19.

14 Dec 2022

Study finds a novel therapeutic target for prevention and treatment of gout

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

14 Dec 2022

The therapeutic effects and safety of psychedelics

Psychedelics are reported to have rapid-onset and long-lasting therapeutic benefits after a single or few doses.

14 Dec 2022

What Germany’s coal miners can teach America about medical debt

Almost every day, Dr. Eckart Rolshoven sees the long shadow of coal mining in his clinic near the big brownstone church that dominates this small town in Germany's Saarland.

14 Dec 2022

States challenge Biden to lower drug prices by allowing imports from Canada

The Biden administration is facing mounting pressure from states to let them import medicine from Canada to help lower prescription drug costs.

14 Dec 2022

Research maps the evolution and natural selection of E. coli bacteria

Antibiotic resistance, when infection-causing bacteria evolve so they are no longer affected by typical antibiotics, is a global concern.

14 Dec 2022

Study seeks to look for a better treatment for endometriosis

Up to 15% of women of reproductive age in the United States suffer from endometriosis, a condition characterized by pelvic pain, menstrual cramps and infertility.

14 Dec 2022

Injuries associated with alcohol use disorders may increase the risk of death in the next year

When people are injured severely enough to require treatment at the hospital and they are either intoxicated or have an alcohol use disorder, they have a fivefold increased risk of dying in the next year, according to a new study in the Journal of Studies on Alcohol and Drugs.

13 Dec 2022

Study finds spike in endocarditis among patients with cocaine or opioid use disorder from 2011 to 2022

The incidence rate of infective endocarditis - a rare but often fatal inflammation of the heart valves - among patients with cocaine use disorder or opioid use disorder increased from 2011 to 2022, with the steepest increase occurring from 2021 to 2022, a new study reports.

13 Dec 2022

Medicaid expansion and increase in PrEP, antiretroviral treatment could result in decline of new HIV infections

Enacting Medicaid expansion in Texas and increasing the use of preventive and antiviral medications could result in a decline of new HIV infections among young Black gay, bisexual, and other men who have sex with men (MSM) in Houston, reports a study in the January issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.

13 Dec 2022

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

Researchers from The University of Texas MD Anderson Cancer Center are presenting compelling findings from three clinical trials at the 2022 American Society of Hematology Annual Meeting.

13 Dec 2022

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Huntington's disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function.

12 Dec 2022

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

The nanomaterial graphene oxide - which is used in everything from electronics to sensors for biomolecules - can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden.

12 Dec 2022

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

An international research team led by Dr Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into the mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

12 Dec 2022

Novel drug shows early potential in combating multiple myeloma

A first-of-its-kind drug known as modakafusp alfa has shown early potential in combating multiple myeloma, a form of bone marrow cancer, in a study presented by researchers from the University of Pennsylvania's Abramson Cancer Center at the 2022 American Society of Hematology Annual Meeting (Abstract 565).

12 Dec 2022

Simplified treatment regimen results in dramatic decrease in early deaths from acute promyelocytic leukemia

The use of a simplified treatment regimen by oncologists, along with management recommendations and 24/7 support provided by a limited and dedicated group of academic disease experts, resulted in a dramatic decrease in early deaths from acute promyelocytic leukemia (APL).

12 Dec 2022

Drugs News and Research

New project on ultrasound device for treatment of neuropathic pain to receive NIH funding

Scientists uncover how FoxH1 factor binds to specific points in the genome

Extraordinary plasticity of the glucocorticoid receptor revealed

Four genetic mutations linked to progressive multifocal leukoencephalopathy

No benefit of low dose apixaban following acute COVID-19

Study finds a novel therapeutic target for prevention and treatment of gout

The therapeutic effects and safety of psychedelics

What Germany’s coal miners can teach America about medical debt

States challenge Biden to lower drug prices by allowing imports from Canada

Research maps the evolution and natural selection of E. coli bacteria

Study seeks to look for a better treatment for endometriosis

Injuries associated with alcohol use disorders may increase the risk of death in the next year

Study finds spike in endocarditis among patients with cocaine or opioid use disorder from 2011 to 2022

Medicaid expansion and increase in PrEP, antiretroviral treatment could result in decline of new HIV infections

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

Novel drug shows early potential in combating multiple myeloma

Simplified treatment regimen results in dramatic decrease in early deaths from acute promyelocytic leukemia

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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