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Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives overactive nerve cells in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

31 Oct 2025

Researchers achieve proof of concept for generating eggs from somatic cells

Researchers at Oregon Health & Science University have accomplished a unique proof of concept to treat infertility by turning skin cells into eggs capable of producing early human embryos.

17 Oct 2025

Microplastics pose potential risks to bone health

The production and use of over 400 million tons of plastic each year has polluted beaches, rivers, and even the deepest parts of the ocean, reaching depths of up to 11,000 meters.

18 Sep 2025

Novel biotechnical vector integrates viral and synthetic features for targeted cancer therapy

Gene therapy offers the possibility of addressing cancer at its molecular roots by targeting disease-causing genes rather than relying solely on surgery, chemotherapy, or radiotherapy.

16 Sep 2025

Understanding how mRNA stability influences immune diseases

A pizza shop with 30 delivery people ought to be able to deliver a lot of pizzas - if their cars don't break down on the way.

5 Sep 2025

Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

Targeting lactate metabolism offers new avenues for cancer treatment

Lactic acid (LA) has transitioned from being perceived as a mere glycolytic waste product to a pivotal regulator of tumor-immune crosstalk.

5 Aug 2025

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress.

24 Jul 2025

Probiotic bacteria found to reshape cell behavior in vitro

This study reveals how probiotic bacteria directly influence brain cell function, highlighting gut-brain communication and potential therapeutic applications.

23 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

ATR FTIR spectroscopy shows high accuracy in breast tissue classification

Histopathology is the gold standard in cancer diagnosis. However, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy has shown diagnostic potential in other settings.

18 Jul 2025

WEE1 identified as a key driver of immune resistance in cancer

Immune checkpoints are regulatory proteins that prevent the immune system from attacking healthy tissues.

15 Jul 2025

Proteome imbalance from aneuploidy linked to mitochondrial dysfunction

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

27 Jun 2025

Protein cleavage mechanism sheds light on severe childhood ciliopathies

New research by Sumeda Nandadasa, PhD, reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, Joubert syndrome and other ciliopathies is cut in half to perform two separate functions, both of which are fundamental to the healthy development of children.

27 Jun 2025