Genetic Engineering News and Research

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Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors.

3 Jul 2025

Next generation CAR-T cells push the boundaries of lymphoma treatment

CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic landscape of lymphoma.

23 Jun 2025

Formation of tiny living bots can reset the cellular aging clock

Modern humans have existed for over 200,000 years, and each new generation has begun with a single cell-dividing, changing shape and function, organizing into tissues, organs, and limbs.

21 Jun 2025

Yellow pigment linked to protection against severe malaria

New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.

13 Jun 2025

Gene editing can trigger inflammatory, senescence-like responses in blood stem cells

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.

5 Jun 2025

Fungal antiviral responses controlled by RNA editing and transcription factor dynamics

The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways.

23 May 2025

Trilobio raises $8M to deliver whole lab automation for biologists

Trilobio, the Company building the fully automated robotic lab-in-a-box for biologists, today announced it has raised $8 million USD Seed investment. The oversubscribed round was led by Initialized Capital, including participation from Argon Ventures and Lowercarbon Capital.

From Trilobio 12 May 2025

AI identifies brain cell types through electrical signatures

A decades-old challenge in neuroscience has been solved by harnessing artificial intelligence (AI) to identify the electrical signatures of different types of brain cells for the first time, as part of a study in mice led by researchers from UCL.

7 May 2025

Trilobio raises $8 M to deliver whole lab automation for biologists

Trilobio, the Company building the fully automated robotic lab-in-a-box for biologists, today announced it has raised $8 million USD Seed investment.

7 May 2025

Gene-edited immune cells show promise against advanced GI cancers

Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers.

3 May 2025

Single DNA mutation disrupts tumor suppressor pathways in blood cancer

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key tumor-suppressing pathways, opening up new avenues for blood cancer treatment.

30 Apr 2025

$Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma$

Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma

Researchers from the Sant Pau Research Institute (IR Sant Pau), in collaboration with Sant Pau Hospital and the Josep Carreras Leukaemia Research Institute, have developed an innovative CAR-T cell therapy targeting the CD30 protein (HSP-CAR30), which has shown high efficacy in patients with refractory CD30+ lymphoma.

29 Apr 2025

New antibody research sparks hope for better whooping cough vaccines

Whooping cough, or pertussis, was once a leading cause of death for children in the U.S. and worldwide before the introduction of vaccines in the 1940s.

7 Apr 2025

Innovative oral vaccine strategy combats intestinal pathogens

The issue of intestinal bacteria is a complex one. On the one hand, we are dependent on the microorganisms because they are the ones that digest the food in our intestine.

4 Apr 2025

Novel insights into tumor microenvironment and gastric cancer therapy

A team of Singapore scientists has made a significant discovery in understanding stomach cancer, a disease that remains one of the deadliest cancers worldwide. By using advanced mapping technologies, they created a detailed "atlas" of stomach tumors, revealing hidden patterns in how cancer cells behave, evolve and interact with their environment. These insights could lead to more precise, targeted treatments that improve survival rates and reduce side effects.

27 Mar 2025

New test could predict life-threatening side effects of cancer immunotherapy

Medical researchers in Japan have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs.

10 Mar 2025

Engineering safe and effective vaccinia virus vectors for next-generation vaccines

Announcing a new article publication for Zoonoses journal. Vaccinia virus (VACV) confers cross-protective immunity against the variola virus, the causative agent of smallpox, and has therefore been extensively exploited as a preventive vaccine. Despite the global eradication of smallpox in the 1980s, research efforts involving VACV have continued due to the potential threat of the variola virus being used as a bioweapon, which poses grave risks to human health.

14 Feb 2025

Groundbreaking malaria vaccine provides high-level protection with just one dose

Scientists at Sanaria and Seattle Children's Research Institute's Center for Global Infectious Disease Research (CGIDR) have unveiled a groundbreaking malaria vaccine, Sanaria® PfSPZ-LARC2 Vaccine, designed to provide high-level protection with just one dose.

12 Feb 2025

Trilobio introduces whole-laboratory automation platform at SLAS2025

Trilobio, developer of whole lab automation solutions for advancing biology research, today introduced the first version of its comprehensive robotics, lab equipment and software platform at the Society for Laboratory Automation and Screening conference, SLAS2025, alongside pilot customer data, demonstrating the platform's abilities in advancing research workflows.

From Trilobio 28 Jan 2025

Researchers utilize mosquito mating to spread malaria-fighting fungi

Researchers have developed genetically modified fungi that can kill malaria-transmitting mosquitoes through sexual transmission, offering a promising solution to target both indoor and outdoor populations.

19 Jan 2025