Glycosylation News and Research

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Novel urine-based prognostic model promises to transform bladder cancer treatment

In a study published in the journal Genes & Diseases, researchers from Fudan University, have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.

21 Nov 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Located in the mucus layer that lines the gastrointestinal tract, mucins - proteins with attached sugar molecules - play a key role in combating bacterial infection and providing a safe haven to friendly gut bacteria through unknown mechanisms.

11 Oct 2023

Eat by the clock: How meal timing tunes your liver's circadian rhythm

A study in Nature Communications delves into how the liver's circadian clock responds to meal timing, impacting fat metabolism and other bodily processes. The research underscores the intricate network that contributes to liver's diurnal rhythms, regulated by protein phosphorylation and nutrient availability.

2 Oct 2023

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.

27 Sep 2023

Innovations in baculovirus–insect cell expression systems

The baculovirus–insect cell expression system—insect cells used in conjunction with the baculovirus expression vector system (BEVS)— remains a crucial technology for manufacturing large and complex proteins. This eukaryotic expression system offers inherent safety, ease of scale-up, flexible product design, and versatility for a broad range of proteins.

From Sino Biological Inc. 20 Sep 2023

Unlocking the power of lectins: BOA emerges as a potent weapon against all SARS-CoV-2 variants

Researchers discover that antiviral lectins like BOA can effectively inhibit SARS-CoV-2 and its variants by targeting spike glycans, opening doors for potential pan-coronavirus treatments. The study reveals that BOA's multivalent interactions make it a potent inhibitor against a range of viral variants, offering promise for future therapeutic strategies.

14 Sep 2023

Study characterizes SARS-CoV-2 Omicron BA.2.86: New variant under watch

Researchers identify a new SARS-CoV-2 variant, BA.2.86, with enhanced ability to evade immunity but lower infectivity compared to current variants. The study highlights the need for global monitoring due to its potential to become a predominant strain if it gains infectivity through mutations.

6 Sep 2023

Scientists develop new technique to study sugars on immune cells

Everyone loves a sweet treat, even our cells. While we typically think of sugar as a component of our diet that gives us energy, sugars are also very important in guiding the activity of our cells.

5 Sep 2023

Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetes

A recent study in the Journal of Biomedical Science examines the critical role of ACE2, an enzyme involved in blood volume and electrolyte balance, in chronic diseases like cardiovascular conditions, diabetes, and COVID-19. The research suggests that ACE2 could serve as both a disease severity biomarker and a therapeutic target.

28 Aug 2023

Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatment

Researchers explore the therapeutic potential of circadian-modulating interventions to treat Alzheimer’s disease.

27 Aug 2023

Glycans and GBPs: How their interplay shapes immunity in infection and autoimmune diseases

Researchers discuss the regulatory roles of glycans and glycan-binding proteins in modulating immune responses.

21 Aug 2023

Scientists develop breakthrough technology for detecting protein modifications

A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures.

1 Aug 2023

Battle against RSV: Computational design paves way for new polyvalent vaccine

Research focuses on the design of a multi-epitope polyvalent vaccine against Human Respiratory Syncytial Virus (RSV), a leading cause of lower respiratory tract infections. The study utilizes computational methods and immunoinformatics tools to predict potential vaccine candidates and their interactions with Toll-like receptors (TLRs).

19 Jun 2023

Glycosylation News and Research

Novel urine-based prognostic model promises to transform bladder cancer treatment

Redefining the battle against Alzheimer's with tau-focused treatments

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Eat by the clock: How meal timing tunes your liver's circadian rhythm

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Innovations in baculovirus–insect cell expression systems

Unlocking the power of lectins: BOA emerges as a potent weapon against all SARS-CoV-2 variants

Study characterizes SARS-CoV-2 Omicron BA.2.86: New variant under watch

Scientists develop new technique to study sugars on immune cells

Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetes

Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatment

Glycans and GBPs: How their interplay shapes immunity in infection and autoimmune diseases

Scientists develop breakthrough technology for detecting protein modifications

Battle against RSV: Computational design paves way for new polyvalent vaccine

Polyphenolic compounds to combine with sugar molecules to create potential life-saving drugs

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

Key insights into immune responses after COVID-19 vaccination in Indigenous people

Precision nutrition and the gut microbiome: the impact of blueberries

Surviving without glucose: uridine-derived ribose as an alternative energy source

Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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