Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Glioblastoma (GBM), the most aggressive primary brain tumor, continues to portend a poor prognosis with median survival under two years, despite standard care involving surgery, radiation, and temozolomide chemotherapy.

30 Oct 2025

New study reveals how the glucocorticoid receptor forms complex structures inside cells

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

27 Oct 2025

New 'GLed' tool enables real-time monitoring of T cell activity

The new 'GLed' tool, unique in its reversibility, allows the functional state of T cells to be observed for the first time, representing a crucial advance in personalizing treatments in immunotherapy, transplants, and autoimmune diseases.

30 Sep 2025

Khat use linked to autoimmune hepatitis in young men

Khat (Catha edulis), a plant chewed for its stimulant effects by millions in East Africa and the Arabian Peninsula, is increasingly recognized for its hepatotoxic potential.

30 Sep 2025

Inflammation at the heart’s core: What clinicians and families can do now

Chronic low-grade inflammation is a key driver of cardiovascular disease, even when cholesterol is controlled. The ACC’s 2025 Scientific Statement highlights hsCRP as a routine risk marker and outlines lifestyle and pharmacologic anti-inflammatory strategies for prevention and treatment.

30 Sep 2025

Novel treatment disrupts tumor immunosuppression in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with a five-year survival rate below 10%.

26 Sep 2025

Scientists outline how future therapies could change type 1 diabetes care

Researchers writing in The Lancet review breakthroughs in type 1 diabetes treatment, from immunotherapies that delay onset to stem-cell β-cell replacement and automated insulin delivery. They stress that equitable access, validated surrogate endpoints, and scalable technologies are crucial for lasting impact.

24 Sep 2025

Longitudinal study reveals how GLP-2 analog therapy transforms the intestinal environment

Researchers from Japan discover that glucagon-like peptide-2 (GLP-2) analogs can deeply and beneficially reshape the intestinal environment.

27 Aug 2025

New nanoparticle drug delivery system targets the spleen for precise lupus treatment

With a $1 million Impact Award from the U.S. Department of Defense, Tianfu Wu, a University of Houston biomedical engineer, is developing a method to send medication directly to the spleen where certain immune cells cause the disease known as lupus, or Systemic Lupus Erythematosus.

18 Aug 2025

Advancing cancer treatment with targeted microrobotic swarms

Cancer remains one of the most challenging diseases to treat, as conventional therapies like chemotherapy and radiotherapy are often hindered by poor specificity, systemic toxicity, and damage to healthy tissues.

18 Aug 2025

Lactylation drives tumor progression and immune evasion in triple negative breast cancer

Breast cancer maintains its position as the most prevalent malignancy in women worldwide, with triple-negative breast cancer (TNBC) representing the most treatment-resistant subtype due to limited therapeutic targets and frequent relapse.

18 Aug 2025

Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

Genetically-engineered immune cells show promise for preventing organ rejection

A Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection.

17 Aug 2025

Implant system can treat Type 1 diabetes by supplying extra oxygen to insulin-secreting cells

Cornell researchers have developed an implant system that can treat Type 1 diabetes by supplying extra oxygen to densely packed insulin-secreting cells, without the need for immunosuppression.

11 Aug 2025

Lauric acid could be a key cancer-fighting compound in coconut oil

Virgin coconut oil and lauric acid show promise in inhibiting cancer cell growth and mitigating chemotherapy toxicity, paving the way for future therapies.

11 Aug 2025

New Swiss study probes lingering fatigue after Legionnaires' disease

Researchers in Switzerland launched the LongLEGIO study to compare the long-term health impacts of Legionnaires’ disease and other bacterial pneumonias. Baseline data reveal key differences in comorbidities and quality of life between the groups, with follow-up underway.

4 Aug 2025

New approach preserves insulin-producing cells in diabetes model

Scientific breakthroughs in one disease don't always shed light on treating other diseases. But that's been the surprising journey of one Mayo Clinic research team.

1 Aug 2025

New genetic marker improves kidney transplant match predictions

Researchers at the University of Pittsburgh have identified a new way of predicting whether a kidney donor and recipient are a good match for transplantation.

17 Jul 2025

WHO maintains global emergency status for mpox following June 2025 IHR Emergency Committee meeting

The Director-General of the World Health Organization (WHO) is hereby transmitting the report of the fourth meeting of the International Health Regulations (2005) (IHR) Emergency Committee (Committee) regarding the upsurge of mpox 2024, held on Thursday, 5 June 2025, from 12:00 to 17:00 CEST.

12 Jul 2025

TMP-SMX in early pregnancy increases risk of birth defects, new study shows

A large US cohort study found that using trimethoprim-sulfamethoxazole (TMP-SMX) for UTI in the first trimester of pregnancy was associated with a higher risk of congenital malformations compared to β-lactam antibiotics. No increased risk was seen with nitrofurantoin or fluoroquinolones.

10 Jul 2025

Immunosuppression News and Research

Further Reading

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

New study reveals how the glucocorticoid receptor forms complex structures inside cells

New 'GLed' tool enables real-time monitoring of T cell activity

Khat use linked to autoimmune hepatitis in young men

Inflammation at the heart’s core: What clinicians and families can do now

Novel treatment disrupts tumor immunosuppression in pancreatic cancer

Scientists outline how future therapies could change type 1 diabetes care

Longitudinal study reveals how GLP-2 analog therapy transforms the intestinal environment

New nanoparticle drug delivery system targets the spleen for precise lupus treatment

Advancing cancer treatment with targeted microrobotic swarms

Lactylation drives tumor progression and immune evasion in triple negative breast cancer

Electrophysiology-based strategies enhance cancer immunotherapy

Genetically-engineered immune cells show promise for preventing organ rejection

Implant system can treat Type 1 diabetes by supplying extra oxygen to insulin-secreting cells

Lauric acid could be a key cancer-fighting compound in coconut oil

New Swiss study probes lingering fatigue after Legionnaires' disease

New approach preserves insulin-producing cells in diabetes model

New genetic marker improves kidney transplant match predictions

WHO maintains global emergency status for mpox following June 2025 IHR Emergency Committee meeting

TMP-SMX in early pregnancy increases risk of birth defects, new study shows

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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