Kidney Failure News and Research

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Expanding the waitlisting criteria for kidney transplantation could improve patient outcomes

The current kidney transplant waitlistingcriterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73m2) and does not consider an individual’s risk of progressing to kidney failure.

10 Nov 2025

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and kidney- protective effects. In the kidney, SGLT2 reabsorbs approximately 97% offiltered glucose in the S1 and S2 segments of the proximal tubule, while SGLT1reabsorbs the remainder in the S3 segment.

8 Nov 2025

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

In late-breaking presentations at the American Society of Nephrology Kidney Week meeting and simultaneously published in two companion papers in JAMA, the findings are based on data from over 70,000 participants across 10 major randomised controlled trials. The meta-analyses were conducted by the SGLT2 Inhibitor Meta-analysis Cardio-Renal Trialists' Consortium (SMART-C), led by The George Institute for Global Health.

7 Nov 2025

Pediatric patients with primary glomerular diseases may experience faster kidney function decline

New research reveals that contrary toconventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney function decline than older patients.

7 Nov 2025

Mismatch in kidney tests may reveal hidden health risks

A mismatch between two common tests for kidney function may indicate a higher risk for kidney failure, heart disease, and death, a new study shows.

7 Nov 2025

Weaning hospitalized patients from dialysis may restore kidney function

Weaning patients with acute kidney injury (AKI) from dialysis while they are still hospitalized may save them from remaining on the treatment for the rest of their lives, according to a new study led by UC San Francisco.

7 Nov 2025

Finerenone offers hope for kidney protection in patients with type 1 diabetes

The drug finerenone has a positive effect on patients with type 1 diabetes and chronic kidney disease.

6 Nov 2025

How early diabetes management influences long-term outcomes

Could slightly elevated blood sugar levels lead to serious health problems in the future? A single patient's question sparked nearly a decade of research leading to the development of a landmark model that could shape how clinicians and researchers understand and manage diabetes across the US.

30 Oct 2025

New imaging technique can map the blood flow of an entire organ in 4D

For the first time, a team of Inserm researchers from the Physics for Medicine Institute (Inserm/ESPCI Paris-PSL/CNRS) has succeeded in mapping the blood flow of an entire organ in animals (heart, kidney and liver) with great precision, in four dimensions: 3D + time.

28 Oct 2025

Low-dose steroids show promise for treating severe kidney inflammation

Will it be possible to treat severe kidney inflammation with fewer drugs in the future? A new study by the University Hospital Bonn (UKB), the University of Bonn, and the University of Hamburg gives cause for hope.

15 Oct 2025

Why improving LE8 scores could save young adults from diabetes

Young adults with prediabetes who maintained higher Life’s Essential 8 (LE8) cardiovascular health scores were far less likely to progress to type 2 diabetes over 13 years. Ideal LE8 profiles, particularly healthy weight, blood pressure, physical activity, and sleep, were strongly associated with regression to normal glucose levels.

14 Oct 2025

Identifying Alport syndrome in children through universal age-3 urine screening

The most common first diagnosis of Alport syndrome in Japan is during the universal age-3 urine screening.

7 Oct 2025

Restoring delta cell function may prevent dangerous hypoglycemic events in diabetes

A new study by the University of California, Davis, shows how cells work together to avoid a sudden drop in blood sugar. Understanding these feedback loops could improve the lives of people with diabetes and help them avoid dangerous hypoglycemia.

3 Oct 2025

Myo-inositol fails to lower pregnancy risks in women with PCOS

Myo-inositol supplementation shows no significant benefits in preventing pregnancy complications for women with PCOS, according to a recent large-scale study.

30 Sep 2025

Stem cell treatment could help millions of people with end-stage kidney disease

More than 4 million people worldwide have end-stage kidney disease that requires hemodialysis, a treatment in which a machine filters waste from the blood.

24 Sep 2025

Scientists use blood chemistry to predict disease years before it strikes

Researchers built the largest plasma metabolome-phenome atlas using 274,241 UK Biobank participants, linking over 73,000 metabolite-trait and 52,000 metabolite-disease associations. The study shows metabolic risk scores can predict diseases years before diagnosis, with strong accuracy for diabetes and kidney complications.

22 Sep 2025

New dialysis filter shows promise for improving survival and health in kidney failure patients

Researchers at London Health Sciences Centre Research Institute (LHSCRI) and Western University's Schulich School of Medicine & Dentistry have launched a clinical trial that is evaluating a new type of dialysis filter called Elisio HX that may significantly improve outcomes for people living with kidney failure across Canada.

22 Sep 2025

New genetic test redefines diagnosis and management of hereditary pancreatitis

A new genetic test developed at Mayo Clinic is redefining how clinicians diagnose and manage hereditary pancreatitis.

11 Sep 2025

New class of antihypertensive medications may have both kidney- and cardio-protective benefits

Adding the novel medication baxdrostat to standard care may help manage high blood pressure and delay the progression of kidney disease in people with chronic kidney disease and uncontrolled high blood pressure , according to preliminary research presented at the American Heart Association's Hypertension Scientific Sessions 2025.

8 Sep 2025

WHO expands essential medicines lists with new cancer and diabetes treatments

Today, the World Health Organization (WHO) has released updated editions of its Model Lists of Essential Medicines (EML) and Essential Medicines for Children (EMLc), adding new treatments for various types of cancer and for diabetes with associated comorbidities such as obesity.

5 Sep 2025