Liquid Chromatography News and Research

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New evidence shows blood-brain barrier remains intact in Alzheimer's mouse model

A team of scientists at Texas Tech University Health Sciences Center (TTUHSC) has published new evidence suggesting that the brain's protective shield - known as the blood-brain barrier (BBB) - remains largely intact in a commonly used mouse model of Alzheimer's disease.

29 Sep 2025

Organophosphate pesticide exposure linked to reduced sperm quality in healthy men

This pilot study found that urinary metabolites of organophosphate pesticides were linked to reduced sperm motility in healthy young men, though results were preliminary. Oxidative stress did not explain the association, suggesting other biological pathways may be involved.

25 Sep 2025

Long COVID linked to heavier periods and symptom flare-ups during menstruation

Researchers found that long COVID is linked to heavier, longer, and more irregular bleeding without disrupting ovulation. Symptom severity also peaks around menstruation, likely driven by hormonal and immune changes.

17 Sep 2025

Core sugars in breast milk fuel gut and brain health beyond 12 months

Researchers reviewed 13 studies of human milk oligosaccharides (HMOs) through 24 months of breastfeeding, analyzing 4,786 samples. Six “core” HMOs remained dominant, with total concentrations plateauing after 12 months and evidence suggesting persistence into the second year.

8 Sep 2025

Roasted Arabica coffee hides powerful antidiabetic molecules

Three novel coffee diterpene esters, caffaldehydes A, B, and C, were discovered in Arabica beans, showcasing significant alpha-glucosidase inhibitory activity.

3 Sep 2025

Compounds show significant inhibitory effects on α-glucosidase

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

2 Sep 2025

Exploring testosterone's influence on cardiovascular, metabolic, reproductive, and mental health

For decades, testosterone has been recognized as the primary driver of male reproductive development and secondary sex characteristics.

1 Sep 2025

Glycosylation emerges as a key player in kidney disease progression

Kidney diseases affect nearly 700 million people worldwide and are a growing cause of mortality and health care costs.

29 Aug 2025

Mediterranean diet lowers dementia risk by altering key metabolites

Researchers linked genetics, plasma metabolites, and Mediterranean diet adherence to dementia risk in two large US cohorts, showing APOE4 homozygotes had distinct metabolic pathways. Diet-related metabolites mediated protection, highlighting precision-prevention opportunities.

26 Aug 2025

Synthetic Psychedelics: A Growing Public Health Concern

In this interview, Jonathan Ferguson discusses how knowledge of an emerging public health concern identified at Pittcon 2024 has evolved a year on.

From Pittcon 26 Aug 2025

Fish oil supplementation can reduce risk of developing type 2 diabetes in prediabetic individuals

Type 2 diabetes (T2D) has become one of the leading chronic diseases worldwide in terms of both incidence and mortality.

20 Aug 2025

Study shows promising anti-diabetic potential of coffee's functional components

18 Aug 2025

Flavonols found in foods can block drug resistance protein and boost medication absorption

Researchers identified specific flavonols that potently inhibit breast cancer resistance protein (BCRP), a key driver of drug resistance and poor oral drug absorption. The study found that these flavonols can reverse chemotherapy resistance in vitro and boost drug exposure in animal models, though clinical translation remains uncertain.

6 Aug 2025

New research reveals why fiber-rich diets fuel you better than refined foods

This study quantifies how much energy the human body harvests from gut microbial fermentation of dietary fiber, integrating bacterial physiology, diet, and metagenomic data. Results reveal that dietary fiber, not microbiome composition, mainly determines the amount of short-chain fatty acids absorbed, impacting daily energy and metabolic health.

31 Jul 2025

Powerful bioactives found in overlooked Amazonian fruits

Lesser-known Amazonian fruits exhibit strong antioxidant and antimicrobial properties, highlighting their role in public health and biotechnology research.

31 Jul 2025

Prenatal phthalates lower boys' verbal IQ but lift girls' performance IQ, Canadian study reveals

Prenatal exposure to certain phthalates, especially DiDP, was linked to slightly lower IQ scores in preschoolers, with boys appearing more vulnerable. Other phthalates, like MMP and MBzP, showed small positive associations, but mixture effects were not significant.

29 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

Muscle-derived vesicles heal damaged cells and reverse disease in new study

Researchers discovered that mitochondria-rich extracellular vesicles (Ti-mitoEVs) from skeletal muscle can deliver healthy mitochondria to damaged cells, restoring energy and promoting tissue repair in mice. The approach reversed acute muscle injury and chronic kidney disease, offering a promising new regenerative therapy.

21 Jul 2025

The Proteoform Puzzle: Unlocking the Next Frontier

In the interview, Lloyd M. Smith discusses proteoforms, an area of research worthy of the next Human Genome Project.

From Pittcon 10 Jul 2025

Warming temperatures and CO2 levels threaten food quality

New preliminary research suggests that a combination of higher atmospheric CO2 and hotter temperatures contribute to a reduction in nutritional quality in food crops, with serious implications for human health and wellbeing.

9 Jul 2025